Compile Data Set for Download or QSAR
Report error Found 174 Enz. Inhib. hit(s) with all data for entry = 11348
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497105BDBM497105(US11001561, Compound 81a | US11702392, Compound 81...)
Affinity DataIC50: 0.300nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 497105BDBM497105(US11001561, Compound 81a | US11702392, Compound 81...)
Affinity DataIC50: 0.5nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497078BDBM497078(US11001561, Compound 66b | US11702392, Compound 66...)
Affinity DataIC50: 0.700nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497145BDBM497145(US11001561, Compound 119b | US11702392, Compound 1...)
Affinity DataIC50: 0.800nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497078BDBM497078(US11001561, Compound 66b | US11702392, Compound 66...)
Affinity DataIC50: 1nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 608905BDBM608905(US11702392, Compound 74a | (3M)-6-[(1S)-1-amino-1,...)
Affinity DataIC50: 1nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 497105BDBM497105(US11001561, Compound 81a | US11702392, Compound 81...)
Affinity DataIC50: 1.10nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497105BDBM497105(US11001561, Compound 81a | US11702392, Compound 81...)
Affinity DataIC50: 1.40nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497088BDBM497088(US11001561, Compound 74a | US11702392, Compound 10...)
Affinity DataIC50: 1.70nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 497078BDBM497078(US11001561, Compound 66b | US11702392, Compound 66...)
Affinity DataIC50: 1.90nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 497078BDBM497078(US11001561, Compound 66b | US11702392, Compound 66...)
Affinity DataIC50: 1.90nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497135BDBM497135(US11001561, Compound 110 | US11702392, Compound 11...)
Affinity DataIC50: 2nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497134BDBM497134(US11001561, Compound 109 | US11702392, Compound 10...)
Affinity DataIC50: 2nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 497088BDBM497088(US11001561, Compound 74a | US11702392, Compound 10...)
Affinity DataIC50: 3.5nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497137BDBM497137(US11001561, Compound 112 | US11702392, Compound 11...)
Affinity DataIC50: 4nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497129BDBM497129(US11001561, Compound 104 | US11702392, Compound 10...)
Affinity DataIC50: 5nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 608920BDBM608920(US11702392, Compound 80c | (3M)-6-[(3R)-3-amino-3H...)
Affinity DataIC50: 5nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 608911BDBM608911(US11702392, Compound 77 | (3M)-6-[(1R,3R)-1-amino-...)
Affinity DataIC50: 6nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497099BDBM497099(US11001561, Compound 79a | US11702392, Compound 79...)
Affinity DataIC50: 6nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497088BDBM497088(US11001561, Compound 74a | US11702392, Compound 10...)
Affinity DataIC50: 6nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497130BDBM497130(US11001561, Compound 105 | US11702392, Compound 10...)
Affinity DataIC50: 6nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497138BDBM497138(US11001561, Compound 113 | US11702392, Compound 11...)
Affinity DataIC50: 6nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 497088BDBM497088(US11001561, Compound 74a | US11702392, Compound 10...)
Affinity DataIC50: 6.40nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 608950BDBM608950(US11702392, Compound 108 | 3-4-[(1S)-1-amino-1,3- ...)
Affinity DataIC50: 7nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 608845BDBM608845(US11702392, Compound 23b | (3M)-6-[(3S,4S)-4-amino...)
Affinity DataIC50: 9nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 608845BDBM608845(US11702392, Compound 23b | (3M)-6-[(3S,4S)-4-amino...)
Affinity DataIC50: 12nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497142BDBM497142(US11001561, Compound 117 | US11702392, Compound 11...)
Affinity DataIC50: 15nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 608892BDBM608892(US11702392, Compound 63b | (3M)-6-[(3S,4S)-4-amino...)
Affinity DataIC50: 15nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497143BDBM497143(US11001561, Compound 118 | US11702392, Compound 11...)
Affinity DataIC50: 16nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 608845BDBM608845(US11702392, Compound 23b | (3M)-6-[(3S,4S)-4-amino...)
Affinity DataIC50: 21nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 608906BDBM608906(US11702392, Compound 74b | (3P)-6-[(1S)-1-amino-1,...)
Affinity DataIC50: 26nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497120BDBM497120(US11001561, Compound 95 | US11702392, Compound 95)
Affinity DataIC50: 27nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497124BDBM497124(US11001561, Compound 99 | US11702392, Compound 99)
Affinity DataIC50: 28nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 608823BDBM608823(US11702392, Compound 3b | (3M)-6-[(3S,4S)-4-amino-...)
Affinity DataIC50: 37nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 608823BDBM608823(US11702392, Compound 3b | (3M)-6-[(3S,4S)-4-amino-...)
Affinity DataIC50: 38nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497074BDBM497074(US11104675, Example 10b | US11001561, Compound 63 ...)
Affinity DataIC50: 39nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497080BDBM497080(US11001561, Compound 67b | US11702392, Compound 67...)
Affinity DataIC50: 41nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 38019BDBM38019(US10093646, Compound 1 | US10301278, Example 00003...)
Affinity DataIC50: 47nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497077BDBM497077(US11001561, Compound 66a | US11702392, Compound 66...)
Affinity DataIC50: 48nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497032BDBM497032(US11001561, Compound 27 | US11702392, Compound 62a)
Affinity DataIC50: 51nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497128BDBM497128(US11001561, Compound 103 | US11702392, Compound 10...)
Affinity DataIC50: 67nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497077BDBM497077(US11001561, Compound 66a | US11702392, Compound 66...)
Affinity DataIC50: 73nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497122BDBM497122(US11001561, Compound 97 | US11702392, Compound 97)
Affinity DataIC50: 78nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497073BDBM497073(US11001561, Compound 62b | US11702392, Compound 62...)
Affinity DataIC50: 81nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497136BDBM497136(US11001561, Compound 111a | US11702392, Compound 1...)
Affinity DataIC50: 93nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 608823BDBM608823(US11702392, Compound 3b | (3M)-6-[(3S,4S)-4-amino-...)
Affinity DataIC50: 93nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 497077BDBM497077(US11001561, Compound 66a | US11702392, Compound 66...)
Affinity DataIC50: 97nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 608909BDBM608909(US11702392, Compound 75 | (3M)-6-[(6R)-6-amino-5,6...)
Affinity DataIC50: 120nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497121BDBM497121(US11001561, Compound 96 | US11702392, Compound 96)
Affinity DataIC50: 150nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 50588245BDBM50588245(CHEMBL5172947 | US11702392, Compound 2b)
Affinity DataIC50: 180nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

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