Compile Data Set for Download or QSAR
Report error Found 42 Enz. Inhib. hit(s) with all data for entry = 10964
TargetHistone deacetylase 3(Human)
City of Hope

US Patent
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50: 3nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
City of Hope

US Patent
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50: 3nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
City of Hope

US Patent
LigandPNGBDBM581349(US11505523, Compound 22b)
Affinity DataIC50: 4.5nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 3(Human)
City of Hope

US Patent
LigandPNGBDBM581349(US11505523, Compound 22b)
Affinity DataIC50: 4.80nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
City of Hope

US Patent
LigandPNGBDBM581349(US11505523, Compound 22b)
Affinity DataIC50: 5.70nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
City of Hope

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: 7.5nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetPolyamine deacetylase HDAC10(Human)
City of Hope

US Patent
LigandPNGBDBM581349(US11505523, Compound 22b)
Affinity DataIC50: 20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 11(Human)
City of Hope

US Patent
LigandPNGBDBM581349(US11505523, Compound 22b)
Affinity DataIC50: 20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 4(Human)
City of Hope

US Patent
LigandPNGBDBM581349(US11505523, Compound 22b)
Affinity DataIC50: 20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 6(Human)
City of Hope

US Patent
LigandPNGBDBM581349(US11505523, Compound 22b)
Affinity DataIC50: 20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 4(Human)
City of Hope

US Patent
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50: 20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 2(Human)
City of Hope

US Patent
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50: 20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 11(Human)
City of Hope

US Patent
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50: 20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 6(Human)
City of Hope

US Patent
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50: 20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetPolyamine deacetylase HDAC10(Human)
City of Hope

US Patent
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50: 20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 4(Human)
City of Hope

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: 20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 6(Human)
City of Hope

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: 20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 2(Human)
City of Hope

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: 20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 3(Human)
City of Hope

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: 20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetPolyamine deacetylase HDAC10(Human)
City of Hope

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: 20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 11(Human)
City of Hope

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: 20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 2(Human)
City of Hope

US Patent
LigandPNGBDBM581349(US11505523, Compound 22b)
Affinity DataIC50: 20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
City of Hope

US Patent
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50: 27.2nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
City of Hope

US Patent
LigandPNGBDBM581364(US11505523, Compound 22f)
Affinity DataIC50: 41.8nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
City of Hope

US Patent
LigandPNGBDBM581365(US11505523, Compound 22g)
Affinity DataIC50: 47.7nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
City of Hope

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: 55.7nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
City of Hope

US Patent
LigandPNGBDBM581356(US11505523, Compound 18a | US11505523, Compound PC...)
Affinity DataIC50: 55.7nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
City of Hope

US Patent
LigandPNGBDBM581361(US11505523, Compound 22a)
Affinity DataIC50: 72.4nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
City of Hope

US Patent
LigandPNGBDBM581362(US11505523, Compound 22c)
Affinity DataIC50: 78nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
City of Hope

US Patent
LigandPNGBDBM581358(US11505523, Compound 18c)
Affinity DataIC50: 112nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
City of Hope

US Patent
LigandPNGBDBM581356(US11505523, Compound 18a | US11505523, Compound PC...)
Affinity DataIC50: 122nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
City of Hope

US Patent
LigandPNGBDBM581366(US11505523, Compound 27a)
Affinity DataIC50: 133nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
City of Hope

US Patent
LigandPNGBDBM581363(US11505523, Compound 22e)
Affinity DataIC50: 174nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
City of Hope

US Patent
LigandPNGBDBM581369(US11505523, Compound 27d)
Affinity DataIC50: 175nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
City of Hope

US Patent
LigandPNGBDBM581368(US11505523, Compound 27c)
Affinity DataIC50: 186nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
City of Hope

US Patent
LigandPNGBDBM581357(US11505523, Compound 18b)
Affinity DataIC50: 191nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
City of Hope

US Patent
LigandPNGBDBM581353(US11505523, Compound 13c | US11505523, Compound 18...)
Affinity DataIC50: 200nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
City of Hope

US Patent
LigandPNGBDBM581352(US11505523, Compound 13a)
Affinity DataIC50: 206nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
City of Hope

US Patent
LigandPNGBDBM581367(US11505523, Compound 27b)
Affinity DataIC50: 289nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
City of Hope

US Patent
LigandPNGBDBM581354(US11505523, Compound 13d)
Affinity DataIC50: 397nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
City of Hope

US Patent
LigandPNGBDBM581353(US11505523, Compound 13c | US11505523, Compound 18...)
Affinity DataIC50: 614nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
City of Hope

US Patent
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 1.86E+3nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)