Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) with all data for entry = 7219
LigandChemical structure of BindingDB Monomer ID 181157BDBM181157(US9138494, Example 9)
Affinity DataIC50: 0.180nMAssay Description:The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2016
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 181154BDBM181154(US9138494, Example 2)
Affinity DataIC50: 0.200nMAssay Description:The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2016
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50419436BDBM50419436(CHEMBL1915747 | US9138494, JNJ-41510417)
Affinity DataIC50: 0.630nMAssay Description:The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2016
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50357701BDBM50357701(CHEMBL1915725 | US9138494, Janssen B-3)
Affinity DataIC50: 0.980nMAssay Description:The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2016
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 181153BDBM181153(US9138494, Example 1)
Affinity DataIC50: 1.05nMAssay Description:The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2016
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 31592BDBM31592(PF-2545920 | substituted pyrazole, 9 | US9138494, ...)
Affinity DataIC50: 1.68nMAssay Description:The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2016
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 181156BDBM181156(US9138494, Example 4)
Affinity DataIC50: 2nMAssay Description:The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2016
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 181155BDBM181155(US9138494, Example 3)
Affinity DataIC50: 4.70nMAssay Description:The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2016
Entry Details
US Patent