Compile Data Set for Download or QSAR
Report error Found 139 Enz. Inhib. hit(s) with all data for entry = 101
TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 50069326BDBM50069326(US9688661, 1-(5-Chloro-2-methylphenyl)-4-(7H-pyrro...)
Affinity DataIC50: 1nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 174018BDBM174018(US9688661, 1-(5-Chloro-2-ethylphenyl)-4-(7H-pyrrol...)
Affinity DataIC50: 1nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1 [861-1152](Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 174018BDBM174018(US9688661, 1-(5-Chloro-2-ethylphenyl)-4-(7H-pyrrol...)
Affinity DataIC50: 1nMAssay Description:Assays were performed with the JAK1 kinase domain (residues 861-1152 of the 1154 amino acid long full-length sequence, accession number P23458 of Uni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 173996BDBM173996(US9688661, 2-(5-Chloro-2-ethylphenyl)-5-(7H-pyrrol...)
Affinity DataIC50: 1nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [833-1187](Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 174018BDBM174018(US9688661, 1-(5-Chloro-2-ethylphenyl)-4-(7H-pyrrol...)
Affinity DataIC50: 1nMAssay Description:Assays were performed with the TYK2 kinase domain (residues 833-1187 of the 1187 amino acid long full-length sequence, accession number P29597 of Uni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 173987BDBM173987(US9688661, 5-(6-Aminopyrimidin-4-yl)-2-(5-chloro-2...)
Affinity DataIC50: 1nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 50069316BDBM50069316(US9688661, 1-[2-Chloro-5-(trifluoromethyl)phenyl]-...)
Affinity DataIC50: 1nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 174032BDBM174032(US9688661, 2-(5-Chloro-2-ethylphenyl)-N-methyl-5-(...)
Affinity DataIC50: 1nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 174031BDBM174031(US9688661, 2-(5-Chloro-2-ethylphenyl)-N-methyl-5-[...)
Affinity DataIC50: 1nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 173985BDBM173985(US9688661, 2-(5-Chloro-2-methylphenyl)-5-(7H-pyrro...)
Affinity DataIC50: 1nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1 [861-1152](Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 174031BDBM174031(US9688661, 2-(5-Chloro-2-ethylphenyl)-N-methyl-5-[...)
Affinity DataIC50: 1nMAssay Description:Assays were performed with the JAK1 kinase domain (residues 861-1152 of the 1154 amino acid long full-length sequence, accession number P23458 of Uni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [833-1187](Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 50069326BDBM50069326(US9688661, 1-(5-Chloro-2-methylphenyl)-4-(7H-pyrro...)
Affinity DataIC50: 2nMAssay Description:Assays were performed with the TYK2 kinase domain (residues 833-1187 of the 1187 amino acid long full-length sequence, accession number P29597 of Uni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 174008BDBM174008(US9688661, 2-[2-Ethyl-5-(trifluoromethyl)phenyl]-5...)
Affinity DataIC50: 2nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 173984BDBM173984(US9688661, 2-(5-Chloro-2-methylphenyl)-5-[6-(methy...)
Affinity DataIC50: 2nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1 [861-1152](Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 50069326BDBM50069326(US9688661, 1-(5-Chloro-2-methylphenyl)-4-(7H-pyrro...)
Affinity DataIC50: 3nMAssay Description:Assays were performed with the JAK1 kinase domain (residues 861-1152 of the 1154 amino acid long full-length sequence, accession number P23458 of Uni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 174037BDBM174037(US9688661, 2-[2-Ethyl-5-(trifluoromethyl)phenyl]-N...)
Affinity DataIC50: 3nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [833-1187](Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 173996BDBM173996(US9688661, 2-(5-Chloro-2-ethylphenyl)-5-(7H-pyrrol...)
Affinity DataIC50: 3nMAssay Description:Assays were performed with the TYK2 kinase domain (residues 833-1187 of the 1187 amino acid long full-length sequence, accession number P29597 of Uni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 173973BDBM173973(US9688661, 3-(5-Chloro-2-ethylphenyl)-N-methyl-5-(...)
Affinity DataIC50: 3nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [833-1187](Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 50069316BDBM50069316(US9688661, 1-[2-Chloro-5-(trifluoromethyl)phenyl]-...)
Affinity DataIC50: 3nMAssay Description:Assays were performed with the TYK2 kinase domain (residues 833-1187 of the 1187 amino acid long full-length sequence, accession number P29597 of Uni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 174034BDBM174034(US9688661, 5-(6-Aminopyrimidin-4-yl)-2-[2-ethyl-5-...)
Affinity DataIC50: 3nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 173935BDBM173935(US9688661, 1-(5-Chloro-2-methylphenyl)-4-(7H-pyrro...)
Affinity DataIC50: 4nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 174007BDBM174007(US9688661, 2-[2-Ethyl-5-(trifluoromethyl)phenyl]-5...)
Affinity DataIC50: 4nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 174036BDBM174036(US9688661, 2-[2-Ethyl-5-(trifluoromethyl)phenyl]-N...)
Affinity DataIC50: 4nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 174006BDBM174006(US9688661, 5-(6-Aminopyrimidin-4-yl)-2-[2-ethyl-5-...)
Affinity DataIC50: 4nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 173970BDBM173970(US9688661, 3-(5-Chloro-2-ethylphenyl)-5-(7H-pyrrol...)
Affinity DataIC50: 4nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1 [861-1152](Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 50069316BDBM50069316(US9688661, 1-[2-Chloro-5-(trifluoromethyl)phenyl]-...)
Affinity DataIC50: 4nMAssay Description:Assays were performed with the JAK1 kinase domain (residues 861-1152 of the 1154 amino acid long full-length sequence, accession number P23458 of Uni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 174020BDBM174020(US9688661, 1-(5-Chloro-2-ethylphenyl)-4-(6,7-dihyd...)
Affinity DataIC50: 5nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 174029BDBM174029(US9688661, 5-(6-Aminopyrimidin-4-yl)-2-(5-chloro-2...)
Affinity DataIC50: 5nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 173968BDBM173968(BDBM50069310 | US9688661, 3-(5-Chloro-2-methylphen...)
Affinity DataIC50: 5nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 173936BDBM173936(US9688661, 1-(5-Chloro-2-ethylphenyl)-4-(7H-pyrrol...)
Affinity DataIC50: 6nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 174027BDBM174027(US9688661, 4-(6-Aminopyrimidin-4-yl)-1-[2-ethyl-5-...)
Affinity DataIC50: 6nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1 [861-1152](Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 174037BDBM174037(US9688661, 2-[2-Ethyl-5-(trifluoromethyl)phenyl]-N...)
Affinity DataIC50: 6nMAssay Description:Assays were performed with the JAK1 kinase domain (residues 861-1152 of the 1154 amino acid long full-length sequence, accession number P23458 of Uni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 174014BDBM174014(US9688661, 1-(5-Chloro-2-methylphenyl)-4-(6,7-dihy...)
Affinity DataIC50: 6nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 173971BDBM173971(US9688661, 3-[2-Ethyl-5-(trifluoromethyl)phenyl]-5...)
Affinity DataIC50: 6nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1 [861-1152](Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 174032BDBM174032(US9688661, 2-(5-Chloro-2-ethylphenyl)-N-methyl-5-(...)
Affinity DataIC50: 6nMAssay Description:Assays were performed with the JAK1 kinase domain (residues 861-1152 of the 1154 amino acid long full-length sequence, accession number P23458 of Uni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 173937BDBM173937(US9688661, 1-[2-Chloro-5-(trifluoromethyl)phenyl]-...)
Affinity DataIC50: 7nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1 [861-1152](Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 173996BDBM173996(US9688661, 2-(5-Chloro-2-ethylphenyl)-5-(7H-pyrrol...)
Affinity DataIC50: 7nMAssay Description:Assays were performed with the JAK1 kinase domain (residues 861-1152 of the 1154 amino acid long full-length sequence, accession number P23458 of Uni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [833-1187](Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 173985BDBM173985(US9688661, 2-(5-Chloro-2-methylphenyl)-5-(7H-pyrro...)
Affinity DataIC50: 7nMAssay Description:Assays were performed with the TYK2 kinase domain (residues 833-1187 of the 1187 amino acid long full-length sequence, accession number P29597 of Uni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [833-1187](Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 173973BDBM173973(US9688661, 3-(5-Chloro-2-ethylphenyl)-N-methyl-5-(...)
Affinity DataIC50: 7nMAssay Description:Assays were performed with the TYK2 kinase domain (residues 833-1187 of the 1187 amino acid long full-length sequence, accession number P29597 of Uni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1 [861-1152](Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 174020BDBM174020(US9688661, 1-(5-Chloro-2-ethylphenyl)-4-(6,7-dihyd...)
Affinity DataIC50: 8nMAssay Description:Assays were performed with the JAK1 kinase domain (residues 861-1152 of the 1154 amino acid long full-length sequence, accession number P23458 of Uni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 174015BDBM174015(US9688661, 4-(6-Aminopyrimidin-4-yl)-1-(5-chloro-2...)
Affinity DataIC50: 8nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1 [861-1152](Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 173984BDBM173984(US9688661, 2-(5-Chloro-2-methylphenyl)-5-[6-(methy...)
Affinity DataIC50: 8nMAssay Description:Assays were performed with the JAK1 kinase domain (residues 861-1152 of the 1154 amino acid long full-length sequence, accession number P23458 of Uni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 174004BDBM174004(US9688661, 2-[2-Methyl-5-(trifluoromethyl)phenyl]-...)
Affinity DataIC50: 8nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1 [861-1152](Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 174014BDBM174014(US9688661, 1-(5-Chloro-2-methylphenyl)-4-(6,7-dihy...)
Affinity DataIC50: 8nMAssay Description:Assays were performed with the JAK1 kinase domain (residues 861-1152 of the 1154 amino acid long full-length sequence, accession number P23458 of Uni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1 [861-1152](Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 173987BDBM173987(US9688661, 5-(6-Aminopyrimidin-4-yl)-2-(5-chloro-2...)
Affinity DataIC50: 8nMAssay Description:Assays were performed with the JAK1 kinase domain (residues 861-1152 of the 1154 amino acid long full-length sequence, accession number P23458 of Uni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [833-1187](Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 174014BDBM174014(US9688661, 1-(5-Chloro-2-methylphenyl)-4-(6,7-dihy...)
Affinity DataIC50: 8nMAssay Description:Assays were performed with the TYK2 kinase domain (residues 833-1187 of the 1187 amino acid long full-length sequence, accession number P29597 of Uni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 173979BDBM173979(US9688661, 3-[2-Ethyl-5-(trifluoromethyl)phenyl]-N...)
Affinity DataIC50: 9nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 173972BDBM173972(US9688661, 3-(5-Chloro-2-methylphenyl)-N-methyl-5-...)
Affinity DataIC50: 9nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1 [861-1152](Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 174034BDBM174034(US9688661, 5-(6-Aminopyrimidin-4-yl)-2-[2-ethyl-5-...)
Affinity DataIC50: 9nMAssay Description:Assays were performed with the JAK1 kinase domain (residues 861-1152 of the 1154 amino acid long full-length sequence, accession number P23458 of Uni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [833-1187](Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 173970BDBM173970(US9688661, 3-(5-Chloro-2-ethylphenyl)-5-(7H-pyrrol...)
Affinity DataIC50: 9nMAssay Description:Assays were performed with the TYK2 kinase domain (residues 833-1187 of the 1187 amino acid long full-length sequence, accession number P29597 of Uni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

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