Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 5813
TargetGonadotropin-releasing hormone receptor(Human)
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405268(US10344034, Example 14 | 1-(4-(7-(2,6-difluorobenz...)
Affinity DataIC50: 0.110nMAssay Description:Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details
US Patent

TargetG_PROTEIN_RECEP_F1_2 domain-containing protein(Rabbit)
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405272(US10344034, Example 9 | 1-(4-(7-(2,6-difluorobenzy...)
Affinity DataIC50: 0.240nMAssay Description:Rabbit: This assay was used to determine the inhibition effect of the present compounds on the activity of rabbit GnRHr protein expressed by rabbit G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details
US Patent

TargetG_PROTEIN_RECEP_F1_2 domain-containing protein(Rabbit)
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405271(US10344034, Example 8 | 1-(4-(3-((dimethylamino)me...)
Affinity DataIC50: 0.270nMAssay Description:Rabbit: This assay was used to determine the inhibition effect of the present compounds on the activity of rabbit GnRHr protein expressed by rabbit G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details
US Patent

TargetGonadotropin-releasing hormone receptor(Human)
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405272(US10344034, Example 9 | 1-(4-(7-(2,6-difluorobenzy...)
Affinity DataIC50: 0.420nMAssay Description:Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details
US Patent

TargetGonadotropin-releasing hormone receptor(Human)
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405278(US10344034, Example 15 | 1-(4-(1-(2,6-difluorobenz...)
Affinity DataIC50: 0.430nMAssay Description:Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details
US Patent

TargetGonadotropin-releasing hormone receptor(Human)
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405270(US10344034, Example 7 | 1-(4-(3-((dimethylamino)me...)
Affinity DataIC50: 0.490nMAssay Description:Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details
US Patent

TargetG_PROTEIN_RECEP_F1_2 domain-containing protein(Rabbit)
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405274(US10344034, Example 11 | 1-(4-(7-(2,6-difluorobenz...)
Affinity DataIC50: 0.570nMAssay Description:Rabbit: This assay was used to determine the inhibition effect of the present compounds on the activity of rabbit GnRHr protein expressed by rabbit G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details
US Patent

TargetGonadotropin-releasing hormone receptor(Human)
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405271(US10344034, Example 8 | 1-(4-(3-((dimethylamino)me...)
Affinity DataIC50: 0.600nMAssay Description:Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details
US Patent

TargetGonadotropin-releasing hormone receptor(Human)
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405268(US10344034, Example 14 | 1-(4-(7-(2,6-difluorobenz...)
Affinity DataIC50: 0.660nMAssay Description:Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details
US Patent

TargetGonadotropin-releasing hormone receptor(Human)
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405273(US10344034, Example 10 | 1-(4-(7-(2,6-difluorobenz...)
Affinity DataIC50: 0.660nMAssay Description:Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details
US Patent

TargetGonadotropin-releasing hormone receptor(Human)
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405267(US10344034, Example 3 | 1-(4-(7-(2,6-difluorobenzy...)
Affinity DataIC50: 0.900nMAssay Description:Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details
US Patent

TargetGonadotropin-releasing hormone receptor(Human)
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405276(US10344034, Example 13 | 1-(4-(1-(2,6-difluorobenz...)
Affinity DataIC50: 0.920nMAssay Description:Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details
US Patent

TargetGonadotropin-releasing hormone receptor(Human)
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405269(US10344034, Example 6 | 1-(4-(3-((dimethylamino)me...)
Affinity DataIC50: 0.960nMAssay Description:Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details
US Patent

TargetGonadotropin-releasing hormone receptor(Human)
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405266(US10344034, Example 2 | 1-(4-(7-(2,6-difluorobenzy...)
Affinity DataIC50: 1.46nMAssay Description:Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details
US Patent

TargetGonadotropin-releasing hormone receptor(Human)
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405275(US10344034, Example 12 | 1-(4-(3-((dimethylamino)m...)
Affinity DataIC50: 2.24nMAssay Description:Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details
US Patent

TargetGonadotropin-releasing hormone receptor(Human)
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405279(US10344034, Example 16 | 1-(4-(1-(2,6-difluorobenz...)
Affinity DataIC50: 2.32nMAssay Description:Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details
US Patent

TargetGonadotropin-releasing hormone receptor(Human)
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405274(US10344034, Example 11 | 1-(4-(7-(2,6-difluorobenz...)
Affinity DataIC50: 4.95nMAssay Description:Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details
US Patent

TargetGonadotropin releasing hormone receptor(Crab-eating macaque)
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405272(US10344034, Example 9 | 1-(4-(7-(2,6-difluorobenzy...)
Affinity DataIC50: 23.2nMAssay Description:Monkey: This assay was used to determine the inhibition effect of the present compounds on the activity of monkey GnRHr protein expressed by monkey G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details
US Patent

TargetGonadotropin releasing hormone receptor(Crab-eating macaque)
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405274(US10344034, Example 11 | 1-(4-(7-(2,6-difluorobenz...)
Affinity DataIC50: 78.6nMAssay Description:Monkey: This assay was used to determine the inhibition effect of the present compounds on the activity of monkey GnRHr protein expressed by monkey G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details
US Patent