Compile Data Set for Download or QSAR
Report error Found 58 Enz. Inhib. hit(s) with all data for entry = 535
TargetBeta-secretase 2(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276786BDBM276786(3-chloro-N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-...)
Affinity DataKi:  0.220nMpH: 5.0Assay Description:Inhibitor IC50s, at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 2(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276793BDBM276793(3-fluoro-N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-...)
Affinity DataKi:  0.240nMpH: 5.0Assay Description:Inhibitor IC50s, at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 2(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276787BDBM276787(3-bromo-N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1...)
Affinity DataKi:  0.380nMpH: 5.0Assay Description:Inhibitor IC50s, at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 2(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276791BDBM276791(8-({4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-diox...)
Affinity DataKi:  0.460nMpH: 5.0Assay Description:Inhibitor IC50s, at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 2(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276788BDBM276788(7-bromo-N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1...)
Affinity DataKi:  0.810nMpH: 5.0Assay Description:Inhibitor IC50s, at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 2(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276796BDBM276796(8-({2,4-difluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-...)
Affinity DataKi:  1.10nMpH: 5.0Assay Description:Inhibitor IC50s, at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276786BDBM276786(3-chloro-N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-...)
Affinity DataKi:  1.20nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276791BDBM276791(8-({4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-diox...)
Affinity DataKi:  1.30nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276791BDBM276791(8-({4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-diox...)
Affinity DataKi:  1.31nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276787BDBM276787(3-bromo-N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1...)
Affinity DataKi:  1.5nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 2(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276797BDBM276797(2-(difluoromethyl)-N-{4-fluoro-3-[(5R)-3-imino-2,5...)
Affinity DataKi:  1.80nMpH: 5.0Assay Description:Inhibitor IC50s, at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276796BDBM276796(8-({2,4-difluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-...)
Affinity DataKi:  2.10nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276793BDBM276793(3-fluoro-N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-...)
Affinity DataKi:  2.10nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276796BDBM276796(8-({2,4-difluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-...)
Affinity DataKi:  2.10nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276793BDBM276793(3-fluoro-N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-...)
Affinity DataKi:  2.10nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276794BDBM276794(N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-dioxi...)
Affinity DataKi:  2.60nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276794BDBM276794(N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-dioxi...)
Affinity DataKi:  2.60nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276788BDBM276788(7-bromo-N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1...)
Affinity DataKi:  2.80nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 2(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276792BDBM276792(4-({4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-diox...)
Affinity DataKi:  3nMpH: 5.0Assay Description:Inhibitor IC50s, at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276803BDBM276803((S)-7-((4-fluoro-3-((R)-3-imino-2,5-dimethyl-1,1-d...)
Affinity DataKi:  3.10nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276792BDBM276792(4-({4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-diox...)
Affinity DataKi:  3.20nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276792BDBM276792(4-({4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-diox...)
Affinity DataKi:  3.20nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 2(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276794BDBM276794(N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-dioxi...)
Affinity DataKi:  3.5nMpH: 5.0Assay Description:Inhibitor IC50s, at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276799BDBM276799(N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-dioxi...)
Affinity DataKi:  4.30nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276799BDBM276799(N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-dioxi...)
Affinity DataKi:  4.30nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 2(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276799BDBM276799(N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-dioxi...)
Affinity DataKi:  4.40nMpH: 5.0Assay Description:Inhibitor IC50s, at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 2(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276790BDBM276790(N-{5-fluoro-4-[(5R)-3-imino-2,5-dimethyl-1,1-dioxi...)
Affinity DataKi:  4.5nMpH: 5.0Assay Description:Inhibitor IC50s, at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276797BDBM276797(2-(difluoromethyl)-N-{4-fluoro-3-[(5R)-3-imino-2,5...)
Affinity DataKi:  5.20nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276797BDBM276797(2-(difluoromethyl)-N-{4-fluoro-3-[(5R)-3-imino-2,5...)
Affinity DataKi:  5.20nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 2(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276789BDBM276789(N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-dioxi...)
Affinity DataKi:  5.80nMpH: 5.0Assay Description:Inhibitor IC50s, at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 2(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276795BDBM276795(N-{5-fluoro-4-[(5R)-3-imino-2,5-dimethyl-1,1-dioxi...)
Affinity DataKi:  6.90nMpH: 5.0Assay Description:Inhibitor IC50s, at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276802BDBM276802((R)-5-(5-(((S)-5-chloro-2,3-dihydro-1H-inden-1-yl)...)
Affinity DataKi:  10.2nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276798BDBM276798(N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-dioxi...)
Affinity DataKi:  10.6nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276789BDBM276789(N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-dioxi...)
Affinity DataKi:  11.7nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276789BDBM276789(N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-dioxi...)
Affinity DataKi:  12nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 2(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276798BDBM276798(N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-dioxi...)
Affinity DataKi:  15.4nMpH: 5.0Assay Description:Inhibitor IC50s, at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276790BDBM276790(N-{5-fluoro-4-[(5R)-3-imino-2,5-dimethyl-1,1-dioxi...)
Affinity DataKi:  16.2nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 2(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276802BDBM276802((R)-5-(5-(((S)-5-chloro-2,3-dihydro-1H-inden-1-yl)...)
Affinity DataKi:  16.6nMpH: 5.0Assay Description:Inhibitor IC50s, at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276795BDBM276795(N-{5-fluoro-4-[(5R)-3-imino-2,5-dimethyl-1,1-dioxi...)
Affinity DataKi:  19.3nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 2(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276803BDBM276803((S)-7-((4-fluoro-3-((R)-3-imino-2,5-dimethyl-1,1-d...)
Affinity DataKi:  22.3nMpH: 5.0Assay Description:Inhibitor IC50s, at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276813BDBM276813(WO2011044181, Example 166)
Affinity DataKi:  41nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276800BDBM276800((R)-5-(5-(((R)-3-chloro-6,7-dihydro-5H-cyc1openta[...)
Affinity DataKi:  41.2nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276806BDBM276806(WO2011044181, Example 103)
Affinity DataKi:  42nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 2(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276804BDBM276804((R)-7-((4-fluoro-3-((R)-3-imino-2,5-dimethyl-1,1-d...)
Affinity DataKi:  42.6nMpH: 5.0Assay Description:Inhibitor IC50s, at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 2(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276805BDBM276805((R)-5-(5-(((S)-3-bromo-5,6,7,8-tetrahydroquinolin-...)
Affinity DataKi:  43.1nMpH: 5.0Assay Description:Inhibitor IC50s, at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276812BDBM276812(WO2011044181, Example 165)
Affinity DataKi:  48nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276801BDBM276801((R)-5-(2-fluoro-5-(((R)-3-(trifluoromethyl)-6,7-di...)
Affinity DataKi:  57.3nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276807BDBM276807(WO2011044181, Example 103a)
Affinity DataKi:  69nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276804BDBM276804((R)-7-((4-fluoro-3-((R)-3-imino-2,5-dimethyl-1,1-d...)
Affinity DataKi:  81nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 2(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 276800BDBM276800((R)-5-(5-(((R)-3-chloro-6,7-dihydro-5H-cyc1openta[...)
Affinity DataKi:  124nMpH: 5.0Assay Description:Inhibitor IC50s, at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

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