BDBM276786 3-chloro-N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl]phenyl}-1,7-naphthyridin-8-amine::US10071998, Example 1

SMILES CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(Nc2nccc3cc(Cl)cnc23)ccc1F

InChI Key InChIKey=GAZOPRYFZALSHV-IBGZPJMESA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 276786   

TargetBeta-secretase 2(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM276786(3-chloro-N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-...)
Affinity DataKi:  0.220nMpH: 5.0Assay Description:Inhibitor IC50s, at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEV...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM276786(3-chloro-N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-...)
Affinity DataKi:  1.20nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent