Compile Data Set for Download or QSAR
Report error Found 208 Enz. Inhib. hit(s) with all data for entry = 11035
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587457BDBM587457(US11534441, Compound 167)
Affinity DataIC50: 0.0500nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587477BDBM587477(US11534441, Compound 187)
Affinity DataIC50: 0.0600nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587460BDBM587460(US11534441, Compound 170)
Affinity DataIC50: 0.0700nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587461BDBM587461(US11534441, Compound 171)
Affinity DataIC50: 0.0700nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587444BDBM587444(US11534441, Compound 154)
Affinity DataIC50: 0.0800nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587372BDBM587372(US11534441, Compound 80)
Affinity DataIC50: 0.0800nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587367BDBM587367(US11534441, Compound 75)
Affinity DataIC50: 0.0900nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587478BDBM587478(US11534441, Compound 188)
Affinity DataIC50: 0.0900nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587348BDBM587348(US11534441, Compound 56)
Affinity DataIC50: 0.100nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587382BDBM587382(US11534441, Compound 91)
Affinity DataIC50: 0.100nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587446BDBM587446(US11534441, Compound 156)
Affinity DataIC50: 0.100nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587483BDBM587483(US11534441, Compound 193)
Affinity DataIC50: 0.100nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587486BDBM587486(US11534441, Compound 196)
Affinity DataIC50: 0.100nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587314BDBM587314(US11534441, Compound 22 | US11534441, Compound 23)
Affinity DataIC50: 0.110nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587363BDBM587363(US11534441, Compound 71)
Affinity DataIC50: 0.110nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587394BDBM587394(US11534441, Compound 103)
Affinity DataIC50: 0.110nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587419BDBM587419(US11534441, Compound 129)
Affinity DataIC50: 0.110nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587392BDBM587392(US11534441, Compound 101)
Affinity DataIC50: 0.110nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587438BDBM587438(US11534441, Compound 148)
Affinity DataIC50: 0.110nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587410BDBM587410(US11534441, Compound 119)
Affinity DataIC50: 0.120nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587368BDBM587368(US11534441, Compound 76)
Affinity DataIC50: 0.120nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587366BDBM587366(US11534441, Compound 74)
Affinity DataIC50: 0.120nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587359BDBM587359(US11534441, Compound 67)
Affinity DataIC50: 0.120nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587395BDBM587395(US11534441, Compound 104)
Affinity DataIC50: 0.130nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587325BDBM587325(US11534441, Compound 33)
Affinity DataIC50: 0.130nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587390BDBM587390(US11534441, Compound 99)
Affinity DataIC50: 0.130nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587482BDBM587482(US11534441, Compound 201 | US11534441, Compound 19...)
Affinity DataIC50: 0.140nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587329BDBM587329(US11534441, Compound 37)
Affinity DataIC50: 0.140nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587447BDBM587447(US11534441, Compound 157)
Affinity DataIC50: 0.140nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587387BDBM587387(US11534441, Compound 96)
Affinity DataIC50: 0.140nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587385BDBM587385(US11534441, Compound 94)
Affinity DataIC50: 0.140nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587332BDBM587332(US11534441, Compound 40)
Affinity DataIC50: 0.150nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587458BDBM587458(US11534441, Compound 168)
Affinity DataIC50: 0.150nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587353BDBM587353(US11534441, Compound 61)
Affinity DataIC50: 0.150nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587379BDBM587379(US11534441, Compound 88)
Affinity DataIC50: 0.160nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587479BDBM587479(US11534441, Compound 189)
Affinity DataIC50: 0.160nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587349BDBM587349(US11534441, Compound 57)
Affinity DataIC50: 0.160nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587413BDBM587413(US11534441, Compound 122)
Affinity DataIC50: 0.160nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587373BDBM587373(US11534441, Compound 82)
Affinity DataIC50: 0.160nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587417BDBM587417(US11534441, Compound 127)
Affinity DataIC50: 0.170nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587327BDBM587327(US11534441, Compound 35 | US11534441, Compound 36)
Affinity DataIC50: 0.170nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587347BDBM587347(US11534441, Compound 55)
Affinity DataIC50: 0.180nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587352BDBM587352(US11534441, Compound 60)
Affinity DataIC50: 0.180nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587471BDBM587471(US11534441, Compound 182 | US11534441, Compound 18...)
Affinity DataIC50: 0.180nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587358BDBM587358(US11534441, Compound 66)
Affinity DataIC50: 0.180nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587422BDBM587422(US11534441, Compound 132)
Affinity DataIC50: 0.180nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587480BDBM587480(US11534441, Compound 190)
Affinity DataIC50: 0.190nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587496BDBM587496(US11534441, Compound 206)
Affinity DataIC50: 0.190nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587370BDBM587370(US11534441, Compound 78)
Affinity DataIC50: 0.190nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 587482BDBM587482(US11534441, Compound 201 | US11534441, Compound 19...)
Affinity DataIC50: 0.190nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

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