Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) with all data for entry = 7735
TargetDipeptidyl peptidase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM107106(US8592371, 7 | US9278976, (3S,5R)-5-[2-(cyclopropa...)
Affinity DataIC50: 1nMpH: 7.5 T: 2°CAssay Description:A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2017
Entry Details
US Patent

TargetDipeptidyl peptidase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM107103(US8592371, 5 | US9278976, (3S,5R)-5-[2-(cyclopenta...)
Affinity DataIC50: 1.30nMpH: 7.5 T: 2°CAssay Description:A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2017
Entry Details
US Patent

TargetDipeptidyl peptidase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM107104(US8592371, 6 | US9278976, (3S,5R)-5-[1-(cyclopropa...)
Affinity DataIC50: 1.60nMpH: 7.5 T: 2°CAssay Description:A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2017
Entry Details
US Patent

TargetDipeptidyl peptidase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM107102(US8592371, 4 | US9278976, (3S,5R)-5-[2-(cyclopenta...)
Affinity DataIC50: 1.60nMpH: 7.5 T: 2°CAssay Description:A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2017
Entry Details
US Patent

TargetDipeptidyl peptidase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM107105(US8592371, 8 | US9278976, (3S,5R)-5-[2-(cyclopropa...)
Affinity DataIC50: 1.90nMpH: 7.5 T: 2°CAssay Description:A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2017
Entry Details
US Patent

TargetDipeptidyl peptidase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM107100(US8592371, 2 | US9278976, (3S,5R)-5-{2-methanesulf...)
Affinity DataIC50: 2.20nMpH: 7.5 T: 2°CAssay Description:A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2017
Entry Details
US Patent

TargetDipeptidyl peptidase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM107099(US8592371, 1 | US9278976, (3S,5R)-2-(2,5-difluorop...)
Affinity DataIC50: 2.5nMpH: 7.5 T: 2°CAssay Description:A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2017
Entry Details
US Patent

TargetDipeptidyl peptidase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM213365(US9278976, (3S,5R)-5-[1-(cyclopentanesulfonyl)-1H,...)
Affinity DataIC50: 2.60nMpH: 7.5 T: 2°CAssay Description:A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2017
Entry Details
US Patent