Compile Data Set for Download or QSAR
Report error Found 132 Enz. Inhib. hit(s) with all data for entry = 1706
TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223358(US9315520, Comparator 7 | US9605007, Comparator 7 ...)
Affinity DataIC50: 1nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223381(US9315520, 96 | US9605007, Example 96 | US9744173,...)
Affinity DataIC50: 2nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM312936(US9605007, Comparator 3 | US9744173, Comparator 4)
Affinity DataIC50: 3nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM336258(N-{2-[(4aR,6S,8aR)-2-Amino-6-methyl-4,4a,5,6-tetra...)
Affinity DataIC50: 4nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223413(US9315520, Comparator 6 | US9605007, Comparator 6 ...)
Affinity DataIC50: 6nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM336255(N-{2-[(4aR,6S,8aR)-2-Amino-6-methyl-4,4a,5,6-tetra...)
Affinity DataIC50: 7nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM336256(N-{2-[(4aR,6S,8aR)-2-Amino-6-methyl-4,4a,5,6-tetra...)
Affinity DataIC50: 9nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM312936(US9605007, Comparator 3 | US9744173, Comparator 4)
Affinity DataIC50: 9nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM336311(N-{2-[(4aR,6S,8aR)-2-Amino-6-methyl-4,4a,5,6-tetra...)
Affinity DataIC50: 11nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223387(US9315520, 102 | US9605007, Example 102 | US974417...)
Affinity DataIC50: 12nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223335(US9315520, 22 | US9605007, Example 22 | US9744173,...)
Affinity DataIC50: 13nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223374(US9315520, 89 | US9605007, Example 89 | US9744173,...)
Affinity DataIC50: 17nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223379(US9315520, 94 | US9605007, Example 94 | US9744173,...)
Affinity DataIC50: 18nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM336608(US9744173, Comparator 5)
Affinity DataIC50: 19nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM312930(US9605007, Example 7 | N-{2-[(4a R, 6S,8aR)-2-Amin...)
Affinity DataIC50: 19nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM336257(N-{2-[(4aR,6S,8aR)-2-Amino-6-methyl-4,4a,5,6-tetra...)
Affinity DataIC50: 22nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223400(US9315520, Example 45 | US9315520, 45 | US9605007,...)
Affinity DataIC50: 23nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223400(US9315520, Example 45 | US9315520, 45 | US9605007,...)
Affinity DataIC50: 23nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223384(US9315520, 99 | US9605007, Example 99 | US9744173,...)
Affinity DataIC50: 25nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetCytochrome P450 2D6(Human)
Pfizer

US Patent
LigandPNGBDBM223398(US9315520, Comparator 2 | US9315520, Comparator 3 ...)
Affinity DataIC50: 30nMAssay Description:CYP2D6 inhibition was obtained by measuring inhibition of 5 uM Dextromethorphan in pooled HLM (HL-MIX-102).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetCytochrome P450 2D6(Human)
Pfizer

US Patent
LigandPNGBDBM312936(US9605007, Comparator 3 | US9744173, Comparator 4)
Affinity DataIC50: 30nMAssay Description:CYP2D6 inhibition was obtained by measuring inhibition of 5 uM Dextromethorphan in pooled HLM (HL-MIX-102).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetCytochrome P450 2D6(Human)
Pfizer

US Patent
LigandPNGBDBM223358(US9315520, Comparator 7 | US9605007, Comparator 7 ...)
Affinity DataIC50: 30nMAssay Description:CYP2D6 inhibition was obtained by measuring inhibition of 5 uM Dextromethorphan in pooled HLM (HL-MIX-102).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetCytochrome P450 2D6(Human)
Pfizer

US Patent
LigandPNGBDBM223413(US9315520, Comparator 6 | US9605007, Comparator 6 ...)
Affinity DataIC50: 30nMAssay Description:CYP2D6 inhibition was obtained by measuring inhibition of 5 uM Dextromethorphan in pooled HLM (HL-MIX-102).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM312928(US9605007, Example 1 | N-{2-[(4aR,6S,8aR)-2-Amino-...)
Affinity DataIC50: 31nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223383(US9315520, 98 | US9605007, Example 98 | US9744173,...)
Affinity DataIC50: 33nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM312930(US9605007, Example 7 | N-{2-[(4a R, 6S,8aR)-2-Amin...)
Affinity DataIC50: 33nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM312930(US9605007, Example 7 | N-{2-[(4a R, 6S,8aR)-2-Amin...)
Affinity DataIC50: 33nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM312928(US9605007, Example 1 | N-{2-[(4aR,6S,8aR)-2-Amino-...)
Affinity DataIC50: 41nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM312928(US9605007, Example 1 | N-{2-[(4aR,6S,8aR)-2-Amino-...)
Affinity DataIC50: 41nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223398(US9315520, Comparator 2 | US9315520, Comparator 3 ...)
Affinity DataIC50: 43nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223330(US9315520, 17 | US9605007, Example 17 | US9744173,...)
Affinity DataIC50: 54nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetCytochrome P450 2D6(Human)
Pfizer

US Patent
LigandPNGBDBM312936(US9605007, Comparator 3 | US9744173, Comparator 4)
Affinity DataIC50: 65nMAssay Description:CYP2D6 inhibition was obtained by measuring inhibition of 5 uM Dextromethorphan in pooled HLM (HL-MIX-102).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223366(US9315520, 53 | US9605007, Example 53 | US9744173,...)
Affinity DataIC50: 65nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223339(US9315520, 26 | US9605007, Example 26 | US9744173,...)
Affinity DataIC50: 68nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM312929(US9605007, Example 2 | N-{2-[(4aR,6S,8aR)-2-Amino-...)
Affinity DataIC50: 73nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM312929(US9605007, Example 2 | N-{2-[(4aR,6S,8aR)-2-Amino-...)
Affinity DataIC50: 73nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223338(US9315520, 25 | US9605007, Example 25 | US9744173,...)
Affinity DataIC50: 74nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223380(US9315520, 95 | US9605007, Example 95 | US9744173,...)
Affinity DataIC50: 75nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223337(US9315520, 24 | US9605007, Example 24 | US9744173,...)
Affinity DataIC50: 81nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223374(US9315520, 89 | US9605007, Example 89 | US9744173,...)
Affinity DataIC50: 82nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223390(US9315520, 105 | US9605007, Example 105 | US974417...)
Affinity DataIC50: 85nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223326(US9315520, 13 | US9605007, Example 13 | US9744173,...)
Affinity DataIC50: 90nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223365(US9315520, 52 | US9605007, Example 52 | US9744173,...)
Affinity DataIC50: 91nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM313052(US9605007, Example 108 | N-{2-[(4aR,6S,8aR)-2-amin...)
Affinity DataIC50: 94nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223364(US9315520, 51 | US9605007, Example 51 | US9744173,...)
Affinity DataIC50: 98nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM336604(US9744173, Comparator 1)
Affinity DataIC50: 100nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223360(US9315520, 47 | US9605007, Example 47 | US9744173,...)
Affinity DataIC50: 101nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223362(US9315520, 49 | US9605007, Example 49 | US9744173,...)
Affinity DataIC50: 103nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223334(US9315520, 21 | US9605007, Example 21 | US9744173,...)
Affinity DataIC50: 106nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223333(US9315520, 20 | US9605007, Example 20 | US9744173,...)
Affinity DataIC50: 108nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

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