Compile Data Set for Download or QSAR
Report error Found 140 Enz. Inhib. hit(s) with all data for entry = 10968
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 50549950BDBM50549950(CHEMBL4751541 | US11505536, Example 66)
Affinity DataIC50: 0.169nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 50549954BDBM50549954(CHEMBL4791380 | US11505536, Example 11)
Affinity DataIC50: 0.222nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581533BDBM581533(US11505536, Example 81 | 6-(4-Ethyl-3-(hydroxymeth...)
Affinity DataIC50: 0.226nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581522BDBM581522(US11505536, Example 70 | 2-(2-Chloro-3-methoxyphen...)
Affinity DataIC50: 0.240nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 50549949BDBM50549949(CHEMBL4753279 | US11505536, Example 82)
Affinity DataIC50: 0.249nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581554BDBM581554(US11505536, Example 102 | (R)-6-(4-Ethyl-3-(hydrox...)
Affinity DataIC50: 0.260nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 50549951BDBM50549951(CHEMBL4745588 | US11505536, Example 52)
Affinity DataIC50: 0.265nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 50549952BDBM50549952(CHEMBL4752247 | US11505536, Example 51)
Affinity DataIC50: 0.267nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581532BDBM581532(US11505536, Example 80 | 2-(2-Chloro-6-fluoro-3-me...)
Affinity DataIC50: 0.273nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581512BDBM581512(US11505536, Example 60 | 2-(5-Chloro-3-methyl-1H-p...)
Affinity DataIC50: 0.286nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581539BDBM581539(US11505536, Example 87 | 2-(2,5-Dimethylphenyl)-6-...)
Affinity DataIC50: 0.292nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581479BDBM581479(US11505536, Example 27 | 2-(2-Chloro-6-fluoropheny...)
Affinity DataIC50: 0.320nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581488BDBM581488(US11505536, Example 36 | 6-(2-Chloro-6-fluoropheny...)
Affinity DataIC50: 0.356nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 50549953BDBM50549953(CHEMBL4751399 | US11505536, Example 93)
Affinity DataIC50: 0.396nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581569BDBM581569(US11505536, Example 117 | 2-(2-Chlorophenyl)-6-(4-...)
Affinity DataIC50: 0.418nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581506BDBM581506(US11505536, Example 54 | 2-(2-Chloro-6-fluoropheny...)
Affinity DataIC50: 0.433nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581521BDBM581521(US11505536, Example 69 | 6-(4-Ethyl-3-(hydroxymeth...)
Affinity DataIC50: 0.435nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581535BDBM581535(US11505536, Example 83 | 6-(4-Ethyl-3-(hydroxymeth...)
Affinity DataIC50: 0.444nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581516BDBM581516(US11505536, Example 64 | 6-(4-Ethyl-3-(hydroxymeth...)
Affinity DataIC50: 0.459nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 50549953BDBM50549953(CHEMBL4751399 | US11505536, Example 93)
Affinity DataIC50: 0.463nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581490BDBM581490(US11505536, Example 38 | (R)-2-(4-Ethyl-3-(hydroxy...)
Affinity DataIC50: 0.464nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581540BDBM581540(US11505536, Example 88 | Racemic-6-(4-Ethyl-3-(hyd...)
Affinity DataIC50: 0.520nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581557BDBM581557(US11505536, Example 105 | 2-(2-(Difluoromethyl)phe...)
Affinity DataIC50: 0.528nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581525BDBM581525(US11505536, Example 73 | 6-(4-Ethyl-3-(hydroxymeth...)
Affinity DataIC50: 0.562nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581527BDBM581527(US11505536, Example 75 | 2-(2,5-Dimethylphenyl)-6-...)
Affinity DataIC50: 0.580nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581519BDBM581519(US11505536, Example 67 | 6-(4-Ethyl-3-(hydroxymeth...)
Affinity DataIC50: 0.605nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581513BDBM581513(US11505536, Example 61 | 2-(3-Chloro-2-methoxy-5-m...)
Affinity DataIC50: 0.617nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581492BDBM581492(US11505536, Example 40 | 2-(4-Ethyl-3-(hydroxymeth...)
Affinity DataIC50: 0.623nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581467BDBM581467(US11505536, Example 15 | 6-(4-Ethyl-3-(hydroxymeth...)
Affinity DataIC50: 0.634nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581555BDBM581555(US11505536, Example 103 | 6-(4-Ethyl-3-(hydroxymet...)
Affinity DataIC50: 0.669nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581466BDBM581466(US11505536, Example 14 | 2-(2-Chlorophenyl)-6-(4-e...)
Affinity DataIC50: 0.724nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581498BDBM581498(US11505536, Example 46 | 6-(4-Ethyl-3-(hydroxymeth...)
Affinity DataIC50: 0.746nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581483BDBM581483(US11505536, Example 31 | 2-(5-Chloro-3-methyl-1H-p...)
Affinity DataIC50: 0.764nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581547BDBM581547(US11505536, Example 95 | 6-(4-Ethyl-3-(hydroxymeth...)
Affinity DataIC50: 0.772nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581505BDBM581505(US11505536, Example 53 | 6-(4-Ethyl-3-(hydroxymeth...)
Affinity DataIC50: 0.778nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581492BDBM581492(US11505536, Example 40 | 2-(4-Ethyl-3-(hydroxymeth...)
Affinity DataIC50: 0.802nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581514BDBM581514(US11505536, Example 62 | 2-(3-Chloro-2-methoxy-5-m...)
Affinity DataIC50: 0.836nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581460BDBM581460(US11505536, Example 8 | 2-(2,6-Dichlorophenyl)-6-(...)
Affinity DataIC50: 0.839nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581582BDBM581582(US11505536, Example 130 | 2-(4-Ethyl-3-(hydroxymet...)
Affinity DataIC50: 0.885nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581500BDBM581500(US11505536, Example 48 | racemic-4-(sec-Butyl)-2-(...)
Affinity DataIC50: 0.907nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581495BDBM581495(US11505536, Example 43 | 2-(2-Chloro-5-methylpheny...)
Affinity DataIC50: 0.917nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581524BDBM581524(US11505536, Example 72 | 2-(2,5-Difluorophenyl)-6-...)
Affinity DataIC50: 0.946nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581459BDBM581459(US11505536, Example 7 | 2-(2,6-Dichlorophenyl)-6-(...)
Affinity DataIC50: 0.965nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581484BDBM581484(US11505536, Example 32 | 2-(4-Ethyl-3-(hydroxymeth...)
Affinity DataIC50: 1.01nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581501BDBM581501(US11505536, Example 49 | 2-(3-Chloro-6-methoxypyri...)
Affinity DataIC50: 1.09nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581590BDBM581590(US11505536, Example 140 | 6-(2-(Difluoromethyl)phe...)
Affinity DataIC50: 1.13nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581487BDBM581487(US11505536, Example 35 | 6-(2-Chloro-6-fluoropheny...)
Affinity DataIC50: 1.15nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581509BDBM581509(US11505536, Example 57 | (R*)-6-(4-Ethyl-3-(hydrox...)
Affinity DataIC50: 1.15nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581553BDBM581553(US11505536, Example 101 | (S)-6-(4-Ethyl-3-(hydrox...)
Affinity DataIC50: 1.19nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581538BDBM581538(US11505536, Example 86 | 6-(4-Ethyl-3-(hydroxymeth...)
Affinity DataIC50: 1.19nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

Displayed 1 to 50 (of 140 total ) | Next | Last >>
Jump to: