Compile Data Set for Download or QSAR
Report error Found 28 Enz. Inhib. hit(s) with all data for entry = 1825
TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 342446BDBM342446(US9771379, Example 21 | N-{2-[(4aR,6R,8aR)-2- amin...)
Affinity DataIC50: 5nMAssay Description:The BACE1 binding assay measured beta-site amyloid precursor protein-cleaving enzyme (BACE) binding as a decrease in the counts of radioligand bound ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 342447BDBM342447(US9771379, Example 22 | N-{2-[(4aR,6R,8aR)-2- amin...)
Affinity DataIC50: 13nMAssay Description:The BACE1 binding assay measured beta-site amyloid precursor protein-cleaving enzyme (BACE) binding as a decrease in the counts of radioligand bound ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 342449BDBM342449(US9771379, Example 24 | N-{2-[(4aR,6R,8aR)-2- amin...)
Affinity DataIC50: 27nMAssay Description:The BACE1 binding assay measured beta-site amyloid precursor protein-cleaving enzyme (BACE) binding as a decrease in the counts of radioligand bound ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 342424BDBM342424(US9771379, Example 5 | N-(2-((5aR,7S,9aR)-2-amino-...)
Affinity DataIC50: 71nMAssay Description:A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 342422BDBM342422(US9771379, Example 3 | N-(2-((4aR,6S,8aR)-2-amino-...)
Affinity DataIC50: 85nMAssay Description:A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 342426BDBM342426(US9771379, Example 7 | N-(2-((4S,4aR,6S,8aR)-2-ami...)
Affinity DataIC50: 112nMAssay Description:A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 342421BDBM342421(US9771379, Example 2 | N-(2-((4aR,6S,8aR)-2-amino-...)
Affinity DataIC50: 123nMAssay Description:A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 342445BDBM342445(US9771379, Example 20 | N-{2-[(4aR,6R,8aR)-2- amin...)
Affinity DataIC50: 124nMAssay Description:The BACE1 binding assay measured beta-site amyloid precursor protein-cleaving enzyme (BACE) binding as a decrease in the counts of radioligand bound ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 342423BDBM342423(US9771379, Example 4 | N-(2-((5aR,7S,9aR)-2-amino-...)
Affinity DataIC50: 146nMAssay Description:A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 342432BDBM342432(US9771379, Example 11a | N-(2-((4aR,6R,8aR)-2- ami...)
Affinity DataIC50: 155nMAssay Description:A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 342448BDBM342448(US9771379, Example 23 | N-{2-[(4aR,6R,8aR)-2- amin...)
Affinity DataIC50: 162nMAssay Description:The BACE1 binding assay measured beta-site amyloid precursor protein-cleaving enzyme (BACE) binding as a decrease in the counts of radioligand bound ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 342438BDBM342438(US9771379, Example 13a | N-(2-((4aR,6R,8aR)-2- ami...)
Affinity DataIC50: 184nMAssay Description:A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 342444BDBM342444(US9771379, Example 19 | N-(2-((4a'R,8a'R)-2'-amino...)
Affinity DataIC50: 185nMAssay Description:A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 342420BDBM342420(US9771379, Example 1 | N-(2-((4aR,6S,8aR)-2-amino-...)
Affinity DataIC50: 214nMAssay Description:A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 342425BDBM342425(US9771379, Example 6 | N-(2-((4S,4aR,6S,8aR)-2-ami...)
Affinity DataIC50: 270nMAssay Description:A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 342430BDBM342430(US9771379, Example 10a | N-(2-((4aR,6R,8aR)-2- ami...)
Affinity DataIC50: 310nMAssay Description:A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 342440BDBM342440(US9771379, Example 15 | N-(2-((4a′R,8a′...)
Affinity DataIC50: 370nMAssay Description:A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 342435BDBM342435(US9771379, Example 12a | N-(2-((4aR,6R,8aR)-2- ami...)
Affinity DataIC50: 371nMAssay Description:A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 342441BDBM342441(US9771379, Example 16 | N-(2-((4a'R,8a'R)-2'-amino...)
Affinity DataIC50: 395nMAssay Description:A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 342428BDBM342428(US9771379, Example 9 | N-(2-((4aR,8aR)-2-amino-6,6...)
Affinity DataIC50: 475nMAssay Description:A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 342443BDBM342443(US9771379, Example 18 | N-(2-((4a'R,8a'R)-2'-amino...)
Affinity DataIC50: 561nMAssay Description:A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 342427BDBM342427(US9771379, Example 8 | N-(2-((4aR,8aR)-2-Amino-6,6...)
Affinity DataIC50: 610nMAssay Description:A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 342439BDBM342439(US9771379, Example 14 | N-(2-((4a′R,8a′...)
Affinity DataIC50: 860nMAssay Description:A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 342442BDBM342442(US9771379, Example 17 | N-(2-((4a'R,8a'R)-2'-amino...)
Affinity DataIC50: 2.26E+3nMAssay Description:A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 342436BDBM342436(US9771379, Example 13b | N-(2-((4aS,6S,8aS)-2- ami...)
Affinity DataIC50: 6.97E+3nMAssay Description:A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 342431BDBM342431(US9771379, Example 11b | N-(2-((4aS,6S,8aS)-2- ami...)
Affinity DataIC50: 1.08E+4nMAssay Description:A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 342433BDBM342433(US9771379, Example 12b | N-(2-((4aS,6S,8aS)-2- ami...)
Affinity DataIC50: 1.50E+4nMAssay Description:A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 342429BDBM342429(US9771379, Example 10b | N-(2-((4aS,6S,8aS)-2- ami...)
Affinity DataIC50: 1.67E+4nMAssay Description:A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent