Compile Data Set for Download or QSAR
Report error Found 130 Enz. Inhib. hit(s) with all data for entry = 2948
TargetRibosomal protein S6 kinase beta-1 [T412E](Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 385993BDBM385993(2-(1-(2,3-dihydro-1H-pyrrolo[2,3]pyrimidin-4-yl)pi...)
Affinity DataIC50: 62nMAssay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetProline-rich AKT1 substrate 1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386011BDBM386011(2-(4-Chloro-phenyl)-2-[4-(5,6,7,8-tetrahydro-pyrid...)
Affinity DataIC50: 62nMAssay Description:A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetRibosomal protein S6 kinase beta-1 [T412E](Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 385992BDBM385992(2-(1-(5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)pip...)
Affinity DataIC50: 62nMAssay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetProline-rich AKT1 substrate 1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386010BDBM386010(2-[4-(5,6,7,8-Tetrahydro-pyrido[2,3-d]pyrimidin-4-...)
Affinity DataIC50: 62nMAssay Description:A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetProline-rich AKT1 substrate 1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386013BDBM386013({2-(3-Fluoro-4-trifluoromethyl-phenyl)-2-[4-(5,6,7...)
Affinity DataIC50: 62nMAssay Description:A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetRibosomal protein S6 kinase beta-1 [T412E](Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386013BDBM386013({2-(3-Fluoro-4-trifluoromethyl-phenyl)-2-[4-(5,6,7...)
Affinity DataIC50: 62nMAssay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetProline-rich AKT1 substrate 1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 385993BDBM385993(2-(1-(2,3-dihydro-1H-pyrrolo[2,3]pyrimidin-4-yl)pi...)
Affinity DataIC50: 62nMAssay Description:A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetProline-rich AKT1 substrate 1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386012BDBM386012({2-(4-Chloro-3-fluoro-phenyl)-2-[4-(5,6,7,8-tetrah...)
Affinity DataIC50: 62nMAssay Description:A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetRibosomal protein S6 kinase beta-1 [T412E](Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386006BDBM386006(2-(4-Chloro-phenyl)-2-[4-(6,7-dihydro-5H-pyrrolo[2...)
Affinity DataIC50: 62nMAssay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetRibosomal protein S6 kinase beta-1 [T412E](Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386010BDBM386010(2-[4-(5,6,7,8-Tetrahydro-pyrido[2,3-d]pyrimidin-4-...)
Affinity DataIC50: 62nMAssay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetProline-rich AKT1 substrate 1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386002BDBM386002(Dimethyl-[2-[4-(5,6,7,8-tetrahydro-pyrido[2,3-d]py...)
Affinity DataIC50: 62nMAssay Description:A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetRibosomal protein S6 kinase beta-1 [T412E](Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386002BDBM386002(Dimethyl-[2-[4-(5,6,7,8-tetrahydro-pyrido[2,3-d]py...)
Affinity DataIC50: 62nMAssay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetProline-rich AKT1 substrate 1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386001BDBM386001({2-(4-Chlorophenyl)-2-[4-(5,6,7,8-tetrahydro-pyrid...)
Affinity DataIC50: 62nMAssay Description:A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetProline-rich AKT1 substrate 1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386014BDBM386014(2-(4-fluorophenyl)-2-[4-(7,8-dihydro-6H-pyrimido[5...)
Affinity DataIC50: 62nMAssay Description:A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetProline-rich AKT1 substrate 1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386016BDBM386016(2-(4-Fluoro-phenyl)-2-[4-(5,6,7,8-tetrahydro-pyrid...)
Affinity DataIC50: 62nMAssay Description:A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetRibosomal protein S6 kinase beta-1 [T412E](Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386012BDBM386012({2-(4-Chloro-3-fluoro-phenyl)-2-[4-(5,6,7,8-tetrah...)
Affinity DataIC50: 300nMAssay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetProline-rich AKT1 substrate 1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 385992BDBM385992(2-(1-(5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)pip...)
Affinity DataIC50: 300nMAssay Description:A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetRibosomal protein S6 kinase beta-1 [T412E](Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386011BDBM386011(2-(4-Chloro-phenyl)-2-[4-(5,6,7,8-tetrahydro-pyrid...)
Affinity DataIC50: 300nMAssay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetRibosomal protein S6 kinase beta-1 [T412E](Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386014BDBM386014(2-(4-fluorophenyl)-2-[4-(7,8-dihydro-6H-pyrimido[5...)
Affinity DataIC50: 300nMAssay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetProline-rich AKT1 substrate 1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386006BDBM386006(2-(4-Chloro-phenyl)-2-[4-(6,7-dihydro-5H-pyrrolo[2...)
Affinity DataIC50: 300nMAssay Description:A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetProline-rich AKT1 substrate 1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386059BDBM386059(4-(4-(1-(4-chloro-3-fluorophenyl)-2-(pyrrolidin-1-...)
Affinity DataIC50: 300nMAssay Description:A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetProline-rich AKT1 substrate 1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386005BDBM386005([2-[4-(7,8-Dihydro-6H-pyrimido[5,4-b][1,4]oxazin-4...)
Affinity DataIC50: 300nMAssay Description:A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetProline-rich AKT1 substrate 1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386022BDBM386022(4-{4-[2-dimethylamino-1-(4-trifluoromethyl-phenyl)...)
Affinity DataIC50: 300nMAssay Description:A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetProline-rich AKT1 substrate 1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386009BDBM386009({2-(4-Chloro-3-fluoro-phenyl)-2-[4-(6,7-dihydro-5H...)
Affinity DataIC50: 300nMAssay Description:A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetRibosomal protein S6 kinase beta-1 [T412E](Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386009BDBM386009({2-(4-Chloro-3-fluoro-phenyl)-2-[4-(6,7-dihydro-5H...)
Affinity DataIC50: 300nMAssay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetProline-rich AKT1 substrate 1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386004BDBM386004(2-(4-Chlorophenyl)-2-[4-(7,8-dihydro-6H-pyrimido[5...)
Affinity DataIC50: 300nMAssay Description:A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetProline-rich AKT1 substrate 1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386003BDBM386003(2-[4-(7,8-Dihydro-6H-pyrimido[5,4-b][1,4]oxazin-4-...)
Affinity DataIC50: 300nMAssay Description:A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetProline-rich AKT1 substrate 1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386020BDBM386020(4-{4-[2-dimethylamino-1-(4-chloro-phenyl)-ethyl]-p...)
Affinity DataIC50: 300nMAssay Description:A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetProline-rich AKT1 substrate 1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386056BDBM386056(4-(4-(1-(4-chloro-3-fluorophenyl)-2-(dimethylamino...)
Affinity DataIC50: 300nMAssay Description:A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetRibosomal protein S6 kinase beta-1 [T412E](Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 385999BDBM385999([2-[4-(6,7-Dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl...)
Affinity DataIC50: 300nMAssay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetRibosomal protein S6 kinase beta-1 [T412E](Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386016BDBM386016(2-(4-Fluoro-phenyl)-2-[4-(5,6,7,8-tetrahydro-pyrid...)
Affinity DataIC50: 300nMAssay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetProline-rich AKT1 substrate 1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 385998BDBM385998([2-[4-(7,8-Dihydro-6H-pyrimido[5,4-b][1,4]oxazin-4...)
Affinity DataIC50: 300nMAssay Description:A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetProline-rich AKT1 substrate 1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 385996BDBM385996({2-(4-Chlorophenyl)-2-[4-(7,8-dihydro-6H-pyrimido[...)
Affinity DataIC50: 300nMAssay Description:A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetRibosomal protein S6 kinase beta-1 [T412E](Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386001BDBM386001({2-(4-Chlorophenyl)-2-[4-(5,6,7,8-tetrahydro-pyrid...)
Affinity DataIC50: 300nMAssay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetProline-rich AKT1 substrate 1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386000BDBM386000({2-(4-Chlorophenyl)-2-[4-(6,7-dihydro-5H-pyrrolo[2...)
Affinity DataIC50: 300nMAssay Description:A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetRibosomal protein S6 kinase beta-1 [T412E](Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386000BDBM386000({2-(4-Chlorophenyl)-2-[4-(6,7-dihydro-5H-pyrrolo[2...)
Affinity DataIC50: 300nMAssay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetProline-rich AKT1 substrate 1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 385999BDBM385999([2-[4-(6,7-Dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl...)
Affinity DataIC50: 300nMAssay Description:A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetProline-rich AKT1 substrate 1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386028BDBM386028(4-{4-[1-(4-trifluoro-phenyl)-2-(piperidin-yl)-ethy...)
Affinity DataIC50: 750nMAssay Description:A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetProline-rich AKT1 substrate 1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386027BDBM386027(4-{4-[1-(4-chloro-phenyl)-2-(piperidin-yl)-ethyl]-...)
Affinity DataIC50: 750nMAssay Description:A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetRibosomal protein S6 kinase beta-1 [T412E](Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386008BDBM386008(2-[4-(6,7-Dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)...)
Affinity DataIC50: 750nMAssay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetRibosomal protein S6 kinase beta-1 [T412E](Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386024BDBM386024(4-{4-[1-(4-chloro-phenyl)-2-(pyrrolidin-yl)-ethyl]...)
Affinity DataIC50: 750nMAssay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetProline-rich AKT1 substrate 1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386008BDBM386008(2-[4-(6,7-Dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)...)
Affinity DataIC50: 750nMAssay Description:A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetProline-rich AKT1 substrate 1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386024BDBM386024(4-{4-[1-(4-chloro-phenyl)-2-(pyrrolidin-yl)-ethyl]...)
Affinity DataIC50: 750nMAssay Description:A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetProline-rich AKT1 substrate 1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386060BDBM386060(4-(4-(1-(4-chloro-3-fluorophenyl)-2-(piperidin-1-y...)
Affinity DataIC50: 750nMAssay Description:A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetRibosomal protein S6 kinase beta-1 [T412E](Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386003BDBM386003(2-[4-(7,8-Dihydro-6H-pyrimido[5,4-b][1,4]oxazin-4-...)
Affinity DataIC50: 750nMAssay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetRibosomal protein S6 kinase beta-1 [T412E](Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386020BDBM386020(4-{4-[2-dimethylamino-1-(4-chloro-phenyl)-ethyl]-p...)
Affinity DataIC50: 750nMAssay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetRibosomal protein S6 kinase beta-1 [T412E](Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386005BDBM386005([2-[4-(7,8-Dihydro-6H-pyrimido[5,4-b][1,4]oxazin-4...)
Affinity DataIC50: 750nMAssay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetRibosomal protein S6 kinase beta-1 [T412E](Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386022BDBM386022(4-{4-[2-dimethylamino-1-(4-trifluoromethyl-phenyl)...)
Affinity DataIC50: 750nMAssay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetRibosomal protein S6 kinase beta-1 [T412E](Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386004BDBM386004(2-(4-Chlorophenyl)-2-[4-(7,8-dihydro-6H-pyrimido[5...)
Affinity DataIC50: 750nMAssay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetProline-rich AKT1 substrate 1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 386015BDBM386015([2-[4-(6,7-Dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl...)
Affinity DataIC50: 750nMAssay Description:A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

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