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Report error Found 48 Enz. Inhib. hit(s) with all data for entry = 6025
TargetOrexin receptor type 2(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104700(US8569311, 1-10)
Affinity DataKi:  0.0800nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin receptor type 2(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104689(US8569311, A-9)
Affinity DataKi:  0.240nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin receptor type 2(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104697(US8569311, 1-1)
Affinity DataKi:  0.240nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin receptor type 2(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104692(US8569311, E-5)
Affinity DataKi:  0.310nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin receptor type 2(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104701(US8569311, 1-15)
Affinity DataKi:  0.350nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin receptor type 2(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104698(US8569311, 1-4)
Affinity DataKi:  0.370nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin receptor type 2(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104703(US8569311, 1-21)
Affinity DataKi:  0.480nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin receptor type 2(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104699(US8569311, 1-8)
Affinity DataKi:  0.5nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin receptor type 2(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104702(US8569311, 1-19)
Affinity DataKi:  0.530nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin receptor type 2(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104690(US8569311, B-3)
Affinity DataKi:  0.540nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin receptor type 2(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104691(US8569311, C-4)
Affinity DataKi:  0.670nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin receptor type 2(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104706(US8569311, 1-28)
Affinity DataKi:  0.670nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin receptor type 2(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104707(US8569311, 1-34)
Affinity DataKi:  0.680nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin/Hypocretin receptor type 1(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104700(US8569311, 1-10)
Affinity DataKi:  0.710nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin/Hypocretin receptor type 1(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104689(US8569311, A-9)
Affinity DataKi:  1nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin receptor type 2(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104708(US8569311, 1-37)
Affinity DataKi:  1.5nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin receptor type 2(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104694(US8569311, G-1)
Affinity DataKi:  1.70nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin receptor type 2(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104704(US8569311, 1-24)
Affinity DataKi:  1.70nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin/Hypocretin receptor type 1(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104697(US8569311, 1-1)
Affinity DataKi:  1.80nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin receptor type 2(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104709(US8569311, 1-38)
Affinity DataKi:  1.90nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetOrexin receptor type 2(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104696(US8569311, I-7)
Affinity DataKi:  2nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin/Hypocretin receptor type 1(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104692(US8569311, E-5)
Affinity DataKi:  2.90nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent
PDB3D3D Structure (crystal)

TargetOrexin/Hypocretin receptor type 1(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104701(US8569311, 1-15)
Affinity DataKi:  3.20nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin/Hypocretin receptor type 1(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104690(US8569311, B-3)
Affinity DataKi:  3.30nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin receptor type 2(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104710(US8569311, 1-42)
Affinity DataKi:  3.80nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetOrexin/Hypocretin receptor type 1(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104699(US8569311, 1-8)
Affinity DataKi:  6.80nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin/Hypocretin receptor type 1(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104703(US8569311, 1-21)
Affinity DataKi:  7.10nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin/Hypocretin receptor type 1(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104707(US8569311, 1-34)
Affinity DataKi:  8.20nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin receptor type 2(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104705(US8569311, 1-27)
Affinity DataKi:  10nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin/Hypocretin receptor type 1(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104702(US8569311, 1-19)
Affinity DataKi:  10nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin/Hypocretin receptor type 1(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104698(US8569311, 1-4)
Affinity DataKi:  12nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin/Hypocretin receptor type 1(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104694(US8569311, G-1)
Affinity DataKi:  14nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin/Hypocretin receptor type 1(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104706(US8569311, 1-28)
Affinity DataKi:  17nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin receptor type 2(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104711(US8569311, 1-43)
Affinity DataKi:  22nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetOrexin/Hypocretin receptor type 1(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104691(US8569311, C-4)
Affinity DataKi:  22nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin receptor type 2(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104688(US8569311, 2-1)
Affinity DataKi:  29nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetOrexin/Hypocretin receptor type 1(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104696(US8569311, I-7)
Affinity DataKi:  30nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin/Hypocretin receptor type 1(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104704(US8569311, 1-24)
Affinity DataKi:  36nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin receptor type 2(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104695(US8569311, H-4)
Affinity DataKi:  37nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin/Hypocretin receptor type 1(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104708(US8569311, 1-37)
Affinity DataKi:  55nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin/Hypocretin receptor type 1(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104710(US8569311, 1-42)
Affinity DataKi:  64nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetOrexin/Hypocretin receptor type 1(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104705(US8569311, 1-27)
Affinity DataKi:  75nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin/Hypocretin receptor type 1(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104695(US8569311, H-4)
Affinity DataKi:  84nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin/Hypocretin receptor type 1(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104709(US8569311, 1-38)
Affinity DataKi:  86nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetOrexin/Hypocretin receptor type 1(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104688(US8569311, 2-1)
Affinity DataKi:  96nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetOrexin/Hypocretin receptor type 1(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104711(US8569311, 1-43)
Affinity DataKi:  140nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetOrexin/Hypocretin receptor type 1(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104693(US8569311, F-4)
Affinity DataKi:  260nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetOrexin receptor type 2(Rat)
Merch Sharp & Dohme

US Patent
LigandPNGBDBM104693(US8569311, F-4)
Affinity DataKi:  410nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In DepthDetails US Patent