Compile Data Set for Download or QSAR
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Found 20 Enz. Inhib. hit(s) with all data for entry = 9708
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Dongguan Zhenxing-Beite Medicine Technology

US Patent
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  4.60nMAssay Description:In the case of Km ATP, EGFR T790M/L858R protein kinase activity was tested by Caliper mobility shift assay (referring to J Biomol Screen 14:31, 2009)...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Dongguan Zhenxing-Beite Medicine Technology

US Patent
LigandPNGBDBM482870((S)-1-(2-(8-amino-1-(4-(benzyloxy)phenyl)imidazo[1...)
Affinity DataIC50: <100nMAssay Description:Activity of BTK protein kinase was tested by Caliper mobility shift assay (referring to J Biomol Screen 14:31, 2009). The compound of the present dis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Dongguan Zhenxing-Beite Medicine Technology

US Patent
LigandPNGBDBM483356(US10919899, Compound 25)
Affinity DataIC50: <100nMAssay Description:Activity of BTK protein kinase was tested by Caliper mobility shift assay (referring to J Biomol Screen 14:31, 2009). The compound of the present dis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Dongguan Zhenxing-Beite Medicine Technology

US Patent
LigandPNGBDBM483355(US10919899, Compound 21)
Affinity DataIC50: <100nMAssay Description:Activity of BTK protein kinase was tested by Caliper mobility shift assay (referring to J Biomol Screen 14:31, 2009). The compound of the present dis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Dongguan Zhenxing-Beite Medicine Technology

US Patent
LigandPNGBDBM50175583(ACP-196 | Acalabrutinib | US10239883, Example 6 | ...)
Affinity DataIC50: <100nMAssay Description:Activity of BTK protein kinase was tested by Caliper mobility shift assay (referring to J Biomol Screen 14:31, 2009). The compound of the present dis...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))
Dongguan Zhenxing-Beite Medicine Technology

US Patent
LigandPNGBDBM50175583(ACP-196 | Acalabrutinib | US10239883, Example 6 | ...)
Affinity DataIC50:  195nMAssay Description:The inhibitory activities of the compound to Tec, Txk, and ITK of human were performed by Eurofins Pharma Discovery Services UK Limited (UK) of the U...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))
Dongguan Zhenxing-Beite Medicine Technology

US Patent
LigandPNGBDBM482870((S)-1-(2-(8-amino-1-(4-(benzyloxy)phenyl)imidazo[1...)
Affinity DataIC50:  218nMAssay Description:The inhibitory activities of the compound to Tec, Txk, and ITK of human were performed by Eurofins Pharma Discovery Services UK Limited (UK) of the U...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Dongguan Zhenxing-Beite Medicine Technology

US Patent
LigandPNGBDBM483357(US10919899, Compound 29)
Affinity DataIC50:  550nMAssay Description:Activity of BTK protein kinase was tested by Caliper mobility shift assay (referring to J Biomol Screen 14:31, 2009). The compound of the present dis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase TXK(Homo sapiens (Human))
Dongguan Zhenxing-Beite Medicine Technology

US Patent
LigandPNGBDBM482870((S)-1-(2-(8-amino-1-(4-(benzyloxy)phenyl)imidazo[1...)
Affinity DataIC50:  4.54E+3nMAssay Description:The inhibitory activities of the compound to Tec, Txk, and ITK of human were performed by Eurofins Pharma Discovery Services UK Limited (UK) of the U...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase TXK(Homo sapiens (Human))
Dongguan Zhenxing-Beite Medicine Technology

US Patent
LigandPNGBDBM50175583(ACP-196 | Acalabrutinib | US10239883, Example 6 | ...)
Affinity DataIC50:  5.00E+3nMAssay Description:The inhibitory activities of the compound to Tec, Txk, and ITK of human were performed by Eurofins Pharma Discovery Services UK Limited (UK) of the U...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Dongguan Zhenxing-Beite Medicine Technology

US Patent
LigandPNGBDBM50175583(ACP-196 | Acalabrutinib | US10239883, Example 6 | ...)
Affinity DataIC50: >5.00E+3nMAssay Description:The inhibitory activities of the compound to Tec, Txk, and ITK of human were performed by Eurofins Pharma Discovery Services UK Limited (UK) of the U...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Dongguan Zhenxing-Beite Medicine Technology

US Patent
LigandPNGBDBM483351(US10919899, Compound 5)
Affinity DataIC50:  5.50E+3nMAssay Description:Activity of BTK protein kinase was tested by Caliper mobility shift assay (referring to J Biomol Screen 14:31, 2009). The compound of the present dis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Dongguan Zhenxing-Beite Medicine Technology

US Patent
LigandPNGBDBM483354(US10919899, Compound 17)
Affinity DataIC50:  5.50E+3nMAssay Description:Activity of BTK protein kinase was tested by Caliper mobility shift assay (referring to J Biomol Screen 14:31, 2009). The compound of the present dis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Dongguan Zhenxing-Beite Medicine Technology

US Patent
LigandPNGBDBM483352(US10919899, Compound 6)
Affinity DataIC50: >1.00E+4nMAssay Description:Activity of BTK protein kinase was tested by Caliper mobility shift assay (referring to J Biomol Screen 14:31, 2009). The compound of the present dis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Dongguan Zhenxing-Beite Medicine Technology

US Patent
LigandPNGBDBM483353(US10919899, Compound 9)
Affinity DataIC50: >1.00E+4nMAssay Description:Activity of BTK protein kinase was tested by Caliper mobility shift assay (referring to J Biomol Screen 14:31, 2009). The compound of the present dis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Dongguan Zhenxing-Beite Medicine Technology

US Patent
LigandPNGBDBM482870((S)-1-(2-(8-amino-1-(4-(benzyloxy)phenyl)imidazo[1...)
Affinity DataIC50: >1.00E+4nMAssay Description:In the case of Km ATP, EGFR T790M/L858R protein kinase activity was tested by Caliper mobility shift assay (referring to J Biomol Screen 14:31, 2009)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Dongguan Zhenxing-Beite Medicine Technology

US Patent
LigandPNGBDBM483316(US10919899, Compound 2)
Affinity DataIC50: >1.00E+4nMAssay Description:Activity of BTK protein kinase was tested by Caliper mobility shift assay (referring to J Biomol Screen 14:31, 2009). The compound of the present dis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Dongguan Zhenxing-Beite Medicine Technology

US Patent
LigandPNGBDBM482870((S)-1-(2-(8-amino-1-(4-(benzyloxy)phenyl)imidazo[1...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibitory activities of the compound to Tec, Txk, and ITK of human were performed by Eurofins Pharma Discovery Services UK Limited (UK) of the U...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Dongguan Zhenxing-Beite Medicine Technology

US Patent
LigandPNGBDBM50175583(ACP-196 | Acalabrutinib | US10239883, Example 6 | ...)
Affinity DataIC50: >1.00E+4nMAssay Description:In the case of Km ATP, EGFR T790M/L858R protein kinase activity was tested by Caliper mobility shift assay (referring to J Biomol Screen 14:31, 2009)...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Dongguan Zhenxing-Beite Medicine Technology

US Patent
LigandPNGBDBM483350(US10919899, Compound 3)
Affinity DataIC50: >1.00E+4nMAssay Description:Activity of BTK protein kinase was tested by Caliper mobility shift assay (referring to J Biomol Screen 14:31, 2009). The compound of the present dis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent