Compile Data Set for Download or QSAR
Report error Found 98 Enz. Inhib. hit(s) with all data for entry = 9194
TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448393BDBM448393(US10695334, Example 21 | 7-[(2-{6,6-Difluoro-3-aza...)
Affinity DataKi:  0.100nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448394BDBM448394(US10695334, Example 22 | 1-[(6-{5-Azaspiro[2.3]hex...)
Affinity DataKi:  0.100nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448388BDBM448388(US10695334, Example 17 | 7-[(6-{3-Azabicyclo[3.1.0...)
Affinity DataKi:  0.100nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448390BDBM448390(US10695334, Example 18 | 1-[(6-{6,6-Difluoro-3-aza...)
Affinity DataKi:  0.100nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448386BDBM448386(US10695334, Example 15 | 1-[(6-{6,6-Difluoro-3-aza...)
Affinity DataKi:  0.100nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448387BDBM448387(US10695334, Example 16 | 1-[(6-{3-Azabicyclo[3.1.0...)
Affinity DataKi:  0.100nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448384BDBM448384(US10695334, Example 13 | 7-[(6-{6,6-Difluoro-3-aza...)
Affinity DataKi:  0.100nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448385BDBM448385(US10695334, Example 14 | 1-[(6-{3-Azabicyclo[3.1.0...)
Affinity DataKi:  0.100nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448392BDBM448392(US10695334, Example 20 | 1-[(6-{3-Azabicyclo[3.1.0...)
Affinity DataKi:  0.200nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448395BDBM448395(US10695334, Example 23 | 7-[(2-{3-Azabicyclo[3.1.0...)
Affinity DataKi:  0.300nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448377BDBM448377(US10695334, Example 5 | 1-[(6-{6,6-Difluoro-3-azab...)
Affinity DataKi:  0.300nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448391BDBM448391(US10695334, Example 19 | 1-[(6-{3-Azabicyclo[3.1.0...)
Affinity DataKi:  0.300nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448382BDBM448382(US10695334, Example 11 | 1-[(6-{5-azaspiro[2.3]hex...)
Affinity DataKi:  0.400nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448400BDBM448400(US10695334, Example 47 | N-[(6R)-3-Methyl-2H,4H,5H...)
Affinity DataKi:  0.400nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448378BDBM448378(US10695334, Example 6 | 4-[(6-{3-Azabicyclo[3.1.0]...)
Affinity DataKi:  0.5nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448376BDBM448376(US10695334, Example 3 | 1-[(6-{3-Azabicyclo[3.1.0]...)
Affinity DataKi:  0.5nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448379BDBM448379(US10695334, Example 7 | 4-[(6-{3-Azabicyclo[3.1.0]...)
Affinity DataKi:  0.700nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448411BDBM448411(US10695334, Example 100 | N-[(6R)-3-Methyl-2H,4H,5...)
Affinity DataKi:  0.800nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448396BDBM448396(US10695334, Example 35 | 1{[6-(3,3-Dimethylpyrroli...)
Affinity DataKi:  0.900nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448399BDBM448399(US10695334, Example 46 | 1-({6-[3-(Difluoromethyl)...)
Affinity DataKi:  1nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448416BDBM448416(US10695334, Example 105 | 1-[(6-{3-Azabicyclo[3.1....)
Affinity DataKi:  1nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448397BDBM448397(US10695334, Example 36 | 1-[(6-{6-Azaspiro[3.4]oct...)
Affinity DataKi:  1nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448410BDBM448410(US10695334, Example 99 | 1-({6-[(1R,5S,6S)-6-(Hydr...)
Affinity DataKi:  1nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448407BDBM448407(US10695334, Example 96 | 1-[(6-{3-Azabicyclo[3.1.0...)
Affinity DataKi:  1nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448320BDBM448320(US10695334, Example 1 | 1-[(6-{3-Azabicyclo[3.1.0]...)
Affinity DataKi:  1nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448408BDBM448408(US10695334, Example 97 | 1-[(6-(3-Azabicyclo[3.1.0...)
Affinity DataKi:  1nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448406BDBM448406(US10695334, Example 87 | 1-[(2-{3-Azabicyclo[3.1.0...)
Affinity DataKi:  1nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448403BDBM448403(US10695334, Example 67 | 1-{[6-(3,3-Dimethylazetid...)
Affinity DataKi:  1nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448404BDBM448404(US10695334, Example 71 | 1-{[6-(3-Cyano-3-methylpy...)
Affinity DataKi:  1nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448401BDBM448401(US10695334, Example 52 | N-[(6R)-3-Methyl-2H,4H,5H...)
Affinity DataKi:  1nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448402BDBM448402(US10695334, Example 54 | 1-[(6-{2-Azaspiro[3.31]he...)
Affinity DataKi:  1nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448383BDBM448383(US10695334, Example 12 | 1-[(6-{3-Azabicyclo[3.1.0...)
Affinity DataKi:  2nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448398BDBM448398(US10695334, Example 37 | 1-{[6-(3,3-Difluoropyrrol...)
Affinity DataKi:  2nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448412BDBM448412(US10695334, Example 101 | 1-({4-Methyl-2-[(1R,5S,6...)
Affinity DataKi:  2nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448415BDBM448415(US10695334, Example 104 | 1-[(6-{5-Azaspiro[2.3]he...)
Affinity DataKi:  3nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448380BDBM448380(US10695334, Example 8 | 4-[(6-{3-Azabicyclo[3.1.0]...)
Affinity DataKi:  3nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448414BDBM448414(US10695334, Example 103 | 1-[(6-{3-Azabicyclo[3.1....)
Affinity DataKi:  3nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448413BDBM448413(US10695334, Example 102 | 1-[(6-{3-Azabicyclo[3.1....)
Affinity DataKi:  4nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448405BDBM448405(US10695334, Example 77 | 1-{[6-(3-Fluoro-3-methyla...)
Affinity DataKi:  4nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448381BDBM448381(US10695334, Example 9 | 2-[(6-{3-Azabicyclo[3.1.0]...)
Affinity DataKi:  5nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448409BDBM448409(US10695334, Example 98 | 1-[(6-{3-Azabicyclo[3.1.0...)
Affinity DataKi:  6nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448417BDBM448417(US10695334, Example 108 | 1-[(6-{3-Azabicyclo[3.1....)
Affinity DataKi:  6nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetThymidine kinase, cytosolic(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448408BDBM448408(US10695334, Example 97 | 1-[(6-(3-Azabicyclo[3.1.0...)
Affinity DataIC50: 1.00E+4nMAssay Description:Prior to the assay, human TK1 (R&D Systems) was activated by incubation with human trypsin (Calbiochem) in a 1:10,000 ratio for 15 min at 37° C. For ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetThymidine kinase, cytosolic(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448409BDBM448409(US10695334, Example 98 | 1-[(6-{3-Azabicyclo[3.1.0...)
Affinity DataIC50: 1.00E+4nMAssay Description:Prior to the assay, human TK1 (R&D Systems) was activated by incubation with human trypsin (Calbiochem) in a 1:10,000 ratio for 15 min at 37° C. For ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetThymidine kinase, cytosolic(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448431BDBM448431(US10695334, Example 94 | 1-({6-[(1R,5S,6R)-6-(hydr...)
Affinity DataIC50: 1.00E+4nMAssay Description:Prior to the assay, human TK1 (R&D Systems) was activated by incubation with human trypsin (Calbiochem) in a 1:10,000 ratio for 15 min at 37° C. For ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetThymidine kinase, cytosolic(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448407BDBM448407(US10695334, Example 96 | 1-[(6-{3-Azabicyclo[3.1.0...)
Affinity DataIC50: 1.00E+4nMAssay Description:Prior to the assay, human TK1 (R&D Systems) was activated by incubation with human trypsin (Calbiochem) in a 1:10,000 ratio for 15 min at 37° C. For ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetThymidine kinase, cytosolic(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448429BDBM448429(US10695334, Example 92 | 1-[(2-{6,6-Difluoro-3-aza...)
Affinity DataIC50: 1.00E+4nMAssay Description:Prior to the assay, human TK1 (R&D Systems) was activated by incubation with human trypsin (Calbiochem) in a 1:10,000 ratio for 15 min at 37° C. For ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetThymidine kinase, cytosolic(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448430BDBM448430(US10695334, Example 93 | 1-[(2-{5-Azaspiro[2.3]hex...)
Affinity DataIC50: 1.00E+4nMAssay Description:Prior to the assay, human TK1 (R&D Systems) was activated by incubation with human trypsin (Calbiochem) in a 1:10,000 ratio for 15 min at 37° C. For ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetThymidine kinase, cytosolic(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448427BDBM448427(US10695334, Example 89 | 1-[(6-{6,6-Difluoro-3-aza...)
Affinity DataIC50: 1.00E+4nMAssay Description:Prior to the assay, human TK1 (R&D Systems) was activated by incubation with human trypsin (Calbiochem) in a 1:10,000 ratio for 15 min at 37° C. For ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetThymidine kinase, cytosolic(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 448428BDBM448428(US10695334, Example 90 | 1-[(6-{3-Azabicyclo[3.1.0...)
Affinity DataIC50: 1.00E+4nMAssay Description:Prior to the assay, human TK1 (R&D Systems) was activated by incubation with human trypsin (Calbiochem) in a 1:10,000 ratio for 15 min at 37° C. For ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

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