BDBM448380 4-[(6-{3-Azabicyclo[3.1.0]hexan-3-yl}-2-methylpyridin-3-yl)methyl]-5-cyano-N-[(6R)-3-methyl-1H,4H,5H,6H-cyclopenta[c]pyrazol-6-yl]thiophene-2-carboxamide::US10695334, Example 8
SMILES Cc1n[nH]c2[C@@H](CCc12)NC(=O)c1cc(Cc2ccc(nc2C)N2CC3CC3C2)c(s1)C#N
InChI Key
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 448380
Affinity DataKi: 3nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Prior to the assay, human TK1 (R&D Systems) was activated by incubation with human trypsin (Calbiochem) in a 1:10,000 ratio for 15 min at 37° C. For ...More data for this Ligand-Target Pair