Compile Data Set for Download or QSAR
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Found 24 Enz. Inhib. hit(s) with all data for entry = 11131
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM563034(US11407736, Compound II-28 | US11578078, Compound ...)
Affinity DataIC50:  16.1nMAssay Description:ADP-Glo™ (Promega, Madison, Wis., USA) reagents were thawed at ambient temperature. Kinase Detection Reagent was prepared by mixing kinase detection ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM593700((S)-4-benzyl-N-(5-methyl-4-oxo-7-(7-oxa-2-azaspiro...)
Affinity DataIC50:  23.9nMAssay Description:ADP-Glo™ (Promega, Madison, Wis., USA) reagents were thawed at ambient temperature. Kinase Detection Reagent was prepared by mixing kinase detection ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM563033(US11407736, Compound II-27 | US11578078, Compound ...)
Affinity DataIC50:  27.9nMAssay Description:ADP-Glo™ (Promega, Madison, Wis., USA) reagents were thawed at ambient temperature. Kinase Detection Reagent was prepared by mixing kinase detection ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM593684((S)-N-(8-(6-(3-hydroxy-3-methylbut-1-yn-1-yl)pyrid...)
Affinity DataIC50:  33.4nMAssay Description:ADP-Glo™ (Promega, Madison, Wis., USA) reagents were thawed at ambient temperature. Kinase Detection Reagent was prepared by mixing kinase detection ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM563035(US11407736, Compound II-31 | US11578078, Compound ...)
Affinity DataIC50:  36.3nMAssay Description:ADP-Glo™ (Promega, Madison, Wis., USA) reagents were thawed at ambient temperature. Kinase Detection Reagent was prepared by mixing kinase detection ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM593690((S)-5-benzyl-N-(1-methyl-2-oxo-8-(7-oxa-2-azaspiro...)
Affinity DataIC50:  36.6nMAssay Description:ADP-Glo™ (Promega, Madison, Wis., USA) reagents were thawed at ambient temperature. Kinase Detection Reagent was prepared by mixing kinase detection ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM593696((S)-1-benzyl-N-(1-methyl-2-oxo-8-(7-oxa-2-azaspiro...)
Affinity DataIC50:  38.8nMAssay Description:ADP-Glo™ (Promega, Madison, Wis., USA) reagents were thawed at ambient temperature. Kinase Detection Reagent was prepared by mixing kinase detection ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM593693(N-(1-(methyl-d3)-2-oxo-8-(7-oxa-2-azaspiro[3.5]non...)
Affinity DataIC50:  41.3nMAssay Description:ADP-Glo™ (Promega, Madison, Wis., USA) reagents were thawed at ambient temperature. Kinase Detection Reagent was prepared by mixing kinase detection ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM593692(N-(1-methyl-2-oxo-8-(3-oxa-9-azaspiro[5.5]undecan-...)
Affinity DataIC50:  46.4nMAssay Description:ADP-Glo™ (Promega, Madison, Wis., USA) reagents were thawed at ambient temperature. Kinase Detection Reagent was prepared by mixing kinase detection ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM593701((S)-4-(4-fluorobenzyl)-N-(5-methyl-7-(9-methyl-3,9...)
Affinity DataIC50:  48.8nMAssay Description:ADP-Glo™ (Promega, Madison, Wis., USA) reagents were thawed at ambient temperature. Kinase Detection Reagent was prepared by mixing kinase detection ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM593693(N-(1-(methyl-d3)-2-oxo-8-(7-oxa-2-azaspiro[3.5]non...)
Affinity DataIC50:  54nMAssay Description:ADP-Glo™ (Promega, Madison, Wis., USA) reagents were thawed at ambient temperature. Kinase Detection Reagent was prepared by mixing kinase detection ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM563018(US11407736, Compound I-236 | US11578078, Compound ...)
Affinity DataIC50:  55.9nMAssay Description:ADP-Glo™ (Promega, Madison, Wis., USA) reagents were thawed at ambient temperature. Kinase Detection Reagent was prepared by mixing kinase detection ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM590926(US11564930, Compound I-16)
Affinity DataIC50:  60.4nMAssay Description:ADP-Glo™ (Promega, Madison, Wis., USA) reagents were thawed at ambient temperature. Kinase Detection Reagent was prepared by mixing kinase detection ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM593691(4-benzyl-N-(1-methyl-2-oxo-8-(7-oxa-2-azaspiro[3.5...)
Affinity DataIC50:  61.2nMAssay Description:ADP-Glo™ (Promega, Madison, Wis., USA) reagents were thawed at ambient temperature. Kinase Detection Reagent was prepared by mixing kinase detection ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM593691(4-benzyl-N-(1-methyl-2-oxo-8-(7-oxa-2-azaspiro[3.5...)
Affinity DataIC50:  61.2nMAssay Description:ADP-Glo™ (Promega, Madison, Wis., USA) reagents were thawed at ambient temperature. Kinase Detection Reagent was prepared by mixing kinase detection ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM563017(US11407736, Compound I-235 | US11578078, Compound ...)
Affinity DataIC50:  62.1nMAssay Description:ADP-Glo™ (Promega, Madison, Wis., USA) reagents were thawed at ambient temperature. Kinase Detection Reagent was prepared by mixing kinase detection ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM590927(US11564930, Compound I-17)
Affinity DataIC50:  70.4nMAssay Description:ADP-Glo™ (Promega, Madison, Wis., USA) reagents were thawed at ambient temperature. Kinase Detection Reagent was prepared by mixing kinase detection ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM593689(5-benzyl-N-(1-(methyl-d3)-2-oxo-8-(7-oxa-2-azaspir...)
Affinity DataIC50:  106nMAssay Description:ADP-Glo™ (Promega, Madison, Wis., USA) reagents were thawed at ambient temperature. Kinase Detection Reagent was prepared by mixing kinase detection ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM593678((S)-N-(5-methyl-4-oxo-8-(3-oxa-9-azaspiro[5.5]unde...)
Affinity DataIC50:  193nMAssay Description:ADP-Glo™ (Promega, Madison, Wis., USA) reagents were thawed at ambient temperature. Kinase Detection Reagent was prepared by mixing kinase detection ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM593688(5-benzyl-N-(1-methyl-2-oxo-8-(3-oxa-9-azaspiro[5.5...)
Affinity DataIC50:  373nMAssay Description:ADP-Glo™ (Promega, Madison, Wis., USA) reagents were thawed at ambient temperature. Kinase Detection Reagent was prepared by mixing kinase detection ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM593685(5-benzyl-N-(2-oxo-8-(7-oxa-2-azaspiro[3.5]nonan-2-...)
Affinity DataIC50:  414nMAssay Description:ADP-Glo™ (Promega, Madison, Wis., USA) reagents were thawed at ambient temperature. Kinase Detection Reagent was prepared by mixing kinase detection ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM593687(5-benzyl-N-(1-methyl-2-oxo-8-(2-azaspiro[3.5]nonan...)
Affinity DataIC50:  444nMAssay Description:ADP-Glo™ (Promega, Madison, Wis., USA) reagents were thawed at ambient temperature. Kinase Detection Reagent was prepared by mixing kinase detection ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM593694(N-(1-methyl-2-oxo-8-(2-azaspiro[3.5]nonan-2-yl)-2,...)
Affinity DataIC50:  603nMAssay Description:ADP-Glo™ (Promega, Madison, Wis., USA) reagents were thawed at ambient temperature. Kinase Detection Reagent was prepared by mixing kinase detection ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM593686(N-(8-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-1-methyl-...)
Affinity DataIC50:  808nMAssay Description:ADP-Glo™ (Promega, Madison, Wis., USA) reagents were thawed at ambient temperature. Kinase Detection Reagent was prepared by mixing kinase detection ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent