Compile Data Set for Download or QSAR
Report error Found 216 Enz. Inhib. hit(s) with all data for entry = 3487
TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401852BDBM401852(US10010539, 68 | 2-{5-mMethyl-2-[(3R,6R)-6- methyl...)
Affinity DataIC50: 6.90nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401808BDBM401808(US10010539, 25 | (2-(2H-1,2,3-triazol-2-yl)phenyl)...)
Affinity DataIC50: 7.5nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401853BDBM401853(US10010539, 69 | 2-(2-{(3R,6R)-1-[(2- Ethoxyphenyl...)
Affinity DataIC50: 7.90nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401805BDBM401805(US10010539, 22 | 2-{2-[(3R,6R)-1-({2-[(1S)-2,2-dif...)
Affinity DataIC50: 8.5nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401854BDBM401854(US10010539, 70 | 2-(2-{(3R,6R)-1-[(2- Cyclopropylp...)
Affinity DataIC50: 8.80nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401848BDBM401848(US10010539, 64 | 2-{2-[(3R,6R)-1-{[2-(2,2- Difluor...)
Affinity DataIC50: 8.80nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401855BDBM401855(US10010539, 71 | 2-{5-Methyl-2-[(3R,6R)-6- methyl-...)
Affinity DataIC50: 9.30nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401869BDBM401869(US10010539, 85 | 2-{1-[(3R,6R)-1-({2-[(1S)-2,2- Di...)
Affinity DataIC50: 9.40nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401889BDBM401889(US10010539, 105 | (2R)-1,1,1-Trifluoro-2-{1-[(3R,6...)
Affinity DataIC50: 9.40nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401850BDBM401850(US10010539, 66 | 2-{2-[(3R,6R)-1-{[2- (Difluoromet...)
Affinity DataIC50: 9.60nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401851BDBM401851(US10010539, 67 | 2-{5-Methyl-2-[(3R,6R)-6- methyl-...)
Affinity DataIC50: 10.1nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401890BDBM401890(US10010539, 106)
Affinity DataIC50: 10.6nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401802BDBM401802(US10010539, 19 | ((2R,5R)-5-(4-(2-Hydroxypropan-2-...)
Affinity DataIC50: 12.1nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401846BDBM401846(US10010539, 62 | 2-{5-Methyl-2-[(3R,6R)-6-methyl-1...)
Affinity DataIC50: 12.5nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401888BDBM401888(US10010539, 104 | 1,1,1-Trifluoro-2-{1-[(3R,6R)-6-...)
Affinity DataIC50: 13.4nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401891BDBM401891(US10010539, 107 | 2-{3-Methyl-1-[(3R,6R)-6-methyl-...)
Affinity DataIC50: 13.8nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401784BDBM401784(US10010539, 1 | 1-(2-((2R,5R)-5-(4-(2-Hydroxypropa...)
Affinity DataIC50: 13.8nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401796BDBM401796(US10010539, 13 | (2-(2,2-Difluoroethoxy)pyridin-3-...)
Affinity DataIC50: 14.3nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401789BDBM401789(US10010539, 6 | (2-Cyclopropylphenyl)((2R,5R)-5- (...)
Affinity DataIC50: 14.9nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401801BDBM401801(US10010539, 18 | (2-(2,2-Difluoroethoxy)phenyl)((2...)
Affinity DataIC50: 15nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401849BDBM401849(US10010539, 65 | 2-(2-{(3R,6R)-1-[(2- Ethoxypyridi...)
Affinity DataIC50: 15.1nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401856BDBM401856(US10010539, 72 | 2-{2-[(3R,6R)-1-{[4-Fluoro-2- (2H...)
Affinity DataIC50: 15.2nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401872BDBM401872(US10010539, 88 | 2-{1-[(3R,6R)-6-Methyl-1-({2- [(t...)
Affinity DataIC50: 15.2nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401797BDBM401797(US10010539, 14 | ((2R,5R)-5-(4-(2-Hydroxypropan-2-...)
Affinity DataIC50: 15.9nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401847BDBM401847(US10010539, 63 | 2-{5-Methyl-2-[(3R,6R)-6-methyl-1...)
Affinity DataIC50: 15.9nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401787BDBM401787(US10010539, 4 | ((2R,5R)-5-(4-(2-Hydroxypropan-2- ...)
Affinity DataIC50: 15.9nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401800BDBM401800(US10010539, 17 | ((2R,5R)-5-(4-(2-Hydroxypropan-2-...)
Affinity DataIC50: 16.1nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401785BDBM401785(US10010539, 2 | [1,1'-Biphenyl]-2-yl((2R,5R)-5-(4-...)
Affinity DataIC50: 16.2nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401857BDBM401857(US10010539, 73 | 2-(5-Methyl-2-{(3R,6R)-6- methyl-...)
Affinity DataIC50: 17.4nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401810BDBM401810(US10010539, 27 | (2-(2H-1,2,3-triazol-2-yl)phenyl)...)
Affinity DataIC50: 17.9nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401804BDBM401804(US10010539, 21 | (2-(Difluoromethoxy)phenyl)((2R,5...)
Affinity DataIC50: 18nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401817BDBM401817(US10010539, 33 | 2-{2-[(3R,6R)-6-methyl-1-{[2-(2H-...)
Affinity DataIC50: 18.4nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401875BDBM401875(US10010539, 91 | 2-{1-[(3R,6R)-1-{[4-Fluoro-2-(2H-...)
Affinity DataIC50: 18.8nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401794BDBM401794(US10010539, 11 | 2-{2-[(3R,6R)-6-Methyl-1-({2- [(t...)
Affinity DataIC50: 20nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401859BDBM401859(US10010539, 75 | 2-{1-[(3R,6R)-6-Methyl-1-{[2-(2H-...)
Affinity DataIC50: 21.6nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401799BDBM401799(US10010539, 16 | ((2R,5R)-5-(4-(2-Hydroxypropan-2-...)
Affinity DataIC50: 22.8nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401803BDBM401803(US10010539, 20 | Methyl 2-((2R,5R)-5-(4-(2-hydroxy...)
Affinity DataIC50: 24.6nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401862BDBM401862(US10010539, 78 | 2-(1-{(3R,6R)-1-[(2- Cyclopropylp...)
Affinity DataIC50: 25.5nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401793BDBM401793(US10010539, 10 | ((2R,5R)-5-(4-(2-Hydroxypropan-2-...)
Affinity DataIC50: 26nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401823BDBM401823(US10010539, 39 | 2-{2-[(3R,6R)-1-{[4-fluoro-2-(2H-...)
Affinity DataIC50: 27.1nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401822BDBM401822(US10010539, 38 | 2-{2-[(3R,6R)-1-{[5-fluoro-2-(2H-...)
Affinity DataIC50: 27.5nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401833BDBM401833(US10010539, 49 | 2-(2-{(3R,6R)-6-methyl-1-[(2-pyrr...)
Affinity DataIC50: 29.1nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401792BDBM401792(US10010539, 9 | ((2R,5R)-5-(4-(2-Hydroxypropan-2- ...)
Affinity DataIC50: 30nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401837BDBM401837(US10010539, 53 | 2-{2-[(3R,6R)-6-methyl-1-{[2-meth...)
Affinity DataIC50: 31.1nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401795BDBM401795(US10010539, 12 | (2-Ethoxyphenyl)((2R,5R)-5-(4-(2-...)
Affinity DataIC50: 31.3nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401867BDBM401867(US10010539, 83 | 2-{1-[(3R,6R)-6-Methyl-1-{[2- (tr...)
Affinity DataIC50: 31.4nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401798BDBM401798(US10010539, 15 | ((2R,5R)-5-(4-(2-Hydroxypropan-2-...)
Affinity DataIC50: 32.6nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401874BDBM401874(US10010539, 90 | 2-{1-[(3R,6R)-6-Methyl-1-{[2-(1H-...)
Affinity DataIC50: 33.6nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401814BDBM401814(US10010539, 31 | 2-{2-[(3R,6R)-1-{[3-fluoro-2-(2H-...)
Affinity DataIC50: 36.4nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 401818BDBM401818(US10010539, 34 | 2-{2-[(3R,6R)-6-methyl-1-{[2-(2H-...)
Affinity DataIC50: 36.8nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

Displayed 1 to 50 (of 216 total ) | Next | Last >>
Jump to: