Compile Data Set for Download or QSAR
Report error Found 166 Enz. Inhib. hit(s) with all data for entry = 6172
TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113298BDBM113298(US8633212, 76 | US9212153, 76 | US10336717, Compou...)
Affinity DataIC50: 2.10nMpH: 4.5 T: 2°CAssay Description:Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113223BDBM113223(US8633212, 1)
Affinity DataIC50: 2.60nMpH: 4.5 T: 2°CAssay Description:Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113224BDBM113224(US8633212, 2)
Affinity DataIC50: 3.5nMpH: 4.5 T: 2°CAssay Description:Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113392BDBM113392(US8633212, 578 | US9212153, 578 | US10336717, Comp...)
Affinity DataIC50: 3.90nMAssay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113226BDBM113226(US8633212, 4)
Affinity DataIC50: 4nMpH: 4.5 T: 2°CAssay Description:Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113227BDBM113227(US8633212, 5)
Affinity DataIC50: 4.5nMpH: 4.5 T: 2°CAssay Description:Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113364BDBM113364(US8633212, 543 | US9212153, 543 | US10336717, Comp...)
Affinity DataIC50: 4.5nMAssay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113225BDBM113225(US8633212, 3 | US10336717, Compound 3)
Affinity DataIC50: 4.5nMpH: 4.5 T: 2°CAssay Description:Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113228BDBM113228(US8633212, 6)
Affinity DataIC50: 4.80nMpH: 4.5 T: 2°CAssay Description:Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113352BDBM113352(US8633212, 524 | US9212153, 524 | US10336717, Comp...)
Affinity DataIC50: 5nMAssay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113251BDBM113251(US8633212, 29 | US9212153, 29 | US10336717, Compou...)
Affinity DataIC50: 5.30nMAssay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113230BDBM113230(US8633212, 8)
Affinity DataIC50: 5.90nMpH: 4.5 T: 2°CAssay Description:Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113229BDBM113229(US8633212, 7)
Affinity DataIC50: 5.90nMpH: 4.5 T: 2°CAssay Description:Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113403BDBM113403(US8633212, 593 | US9212153, 593 | US10336717, Comp...)
Affinity DataIC50: 6nMAssay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113412BDBM113412(US8633212, 602 | US9212153, 602 | US10336717, Comp...)
Affinity DataIC50: 6.20nMAssay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113231BDBM113231(US8633212, 9)
Affinity DataIC50: 7nMpH: 4.5 T: 2°CAssay Description:Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113402BDBM113402(US8633212, 592 | US9212153, 592)
Affinity DataIC50: 7nMAssay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113232BDBM113232(US8633212, 10 | US9212153, 10 | US10336717, Compou...)
Affinity DataIC50: 7.40nMpH: 4.5 T: 2°CAssay Description:Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113233BDBM113233(US8633212, 11 | US10336717, Compound 11)
Affinity DataIC50: 7.80nMpH: 4.5 T: 2°CAssay Description:Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113234BDBM113234(US8633212, 12)
Affinity DataIC50: 7.90nMpH: 4.5 T: 2°CAssay Description:Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113346BDBM113346(US8633212, 514 | US9212153, 514 | US10336717, Comp...)
Affinity DataIC50: 8nMAssay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113235BDBM113235(US8633212, 13)
Affinity DataIC50: 8.80nMpH: 4.5 T: 2°CAssay Description:Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113345BDBM113345(US8633212, 513 | US9212153, 513 | US10336717, Comp...)
Affinity DataIC50: 9nMAssay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113343BDBM113343(US8633212, 511 | US9212153, 511 | US10336717, Comp...)
Affinity DataIC50: 9nMAssay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113366BDBM113366(US8633212, 545 | US9212153, 545 | US10336717, Comp...)
Affinity DataIC50: 9.40nMAssay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113333BDBM113333(US8633212, 515 | US8633212, 501 | US9212153, 515 |...)
Affinity DataIC50: 10nMAssay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113363BDBM113363(US8633212, 542 | US9212153, 542 | US10336717, Comp...)
Affinity DataIC50: 11nMAssay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113236BDBM113236(US8633212, 14 | US10336717, Compound 14)
Affinity DataIC50: 11.1nMpH: 4.5 T: 2°CAssay Description:Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113237BDBM113237(US8633212, 15 | US9212153, 15 | US10336717, Compou...)
Affinity DataIC50: 11.2nMpH: 4.5 T: 2°CAssay Description:Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113238BDBM113238(US8633212, 16 | US10336717, Compound 16)
Affinity DataIC50: 11.5nMpH: 4.5 T: 2°CAssay Description:Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113377BDBM113377(US8633212, 561 | US9212153, 561 | US10336717, Comp...)
Affinity DataIC50: 11.7nMAssay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113409BDBM113409(US8633212, 599 | US9212153, 599 | US10336717, Comp...)
Affinity DataIC50: 12nMAssay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113239BDBM113239(US8633212, 17 | US9212153, 17 | US10336717, Compou...)
Affinity DataIC50: 12.1nMpH: 4.5 T: 2°CAssay Description:Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113241BDBM113241(US8633212, 19)
Affinity DataIC50: 14.6nMpH: 4.5 T: 2°CAssay Description:Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113408BDBM113408(US8633212, 598 | US9212153, 598 | US10336717, Comp...)
Affinity DataIC50: 15nMAssay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113333BDBM113333(US8633212, 515 | US8633212, 501 | US9212153, 515 |...)
Affinity DataIC50: 15.8nMAssay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113393BDBM113393(US8633212, 579 | US9212153, 579 | US10336717, Comp...)
Affinity DataIC50: 15.9nMAssay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113240BDBM113240(US8633212, 18 | US9212153, 18 | US10336717, Compou...)
Affinity DataIC50: 16.8nMpH: 4.5 T: 2°CAssay Description:Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113242BDBM113242(US8633212, 20)
Affinity DataIC50: 18.7nMpH: 4.5 T: 2°CAssay Description:Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113243BDBM113243(US8633212, 21 | US9212153, 21 | US10336717, Compou...)
Affinity DataIC50: 18.9nMpH: 4.5 T: 2°CAssay Description:Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113244BDBM113244(US8633212, 22 | US9212153, 22 | US10336717, Compou...)
Affinity DataIC50: 19.3nMpH: 4.5 T: 2°CAssay Description:Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113245BDBM113245(US8633212, 23 | US9212153, 23 | US10336717, Compou...)
Affinity DataIC50: 20.7nMpH: 4.5 T: 2°CAssay Description:Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113365BDBM113365(US8633212, 544 | US9212153, 544 | US10336717, Comp...)
Affinity DataIC50: 21nMAssay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113246BDBM113246(US8633212, 24 | US9212153, 24 | US10336717, Compou...)
Affinity DataIC50: 21nMpH: 4.5 T: 2°CAssay Description:Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113369BDBM113369(US8633212, 548)
Affinity DataIC50: 23nMAssay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113372BDBM113372(US8633212, 552 | US9212153, 552 | US10336717, Comp...)
Affinity DataIC50: 25nMAssay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113247BDBM113247(US8633212, 25)
Affinity DataIC50: 26.2nMpH: 4.5 T: 2°CAssay Description:Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113330BDBM113330(US8633212, 498 | US9212153, 498 | US10336717, Comp...)
Affinity DataIC50: 27.1nMAssay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113325BDBM113325(US8633212, 493 | US9212153, 493 | US10336717, Comp...)
Affinity DataIC50: 29.8nMAssay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetIsoform C of Beta-secretase 1 (BACE-I-457)(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 113414BDBM113414(US8633212, 604 | US9212153, 604 | US10336717, Comp...)
Affinity DataIC50: 31nMAssay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

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