Compile Data Set for Download or QSAR
Report error Found 15 Enz. Inhib. hit(s) with all data for entry = 7538
TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM200301(US9226927, 4)
Affinity DataIC50: 1.40nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM200304(US9226927, 11)
Affinity DataIC50: 1.70nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM200302(US9226927, 8a)
Affinity DataIC50: 1.90nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM200314(US9226927, 27a)
Affinity DataIC50: 2.80nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM200311(US9226927, 25f)
Affinity DataIC50: 2.90nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM200307(US9226927, 25b)
Affinity DataIC50: 4.5nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM200308(US9226927, 25c)
Affinity DataIC50: 5.5nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM200305(US9226927, 14)
Affinity DataIC50: 5.80nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM200310(US9226927, 25e)
Affinity DataIC50: 6.40nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM200303(US9226927, 8b)
Affinity DataIC50: 6.60nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM200309(US9226927, 25d)
Affinity DataIC50: 10.2nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM200312(US9226927, 25g)
Affinity DataIC50: 12.9nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM200313(US9226927, 25h)
Affinity DataIC50: 16.5nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM200315(US9226927, 27b)
Affinity DataIC50: 18nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM200306(US9226927, 25a)
Affinity DataIC50: 18.7nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
US Patent