Compile Data Set for Download or QSAR
Report error Found 16 Enz. Inhib. hit(s) with all data for entry = 6276
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
F. Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 120141BDBM120141(US8697708, 224)
Affinity DataKi:  0.300nM ΔG°:  -53.8kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
F. Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 120132BDBM120132(US8697708, 18)
Affinity DataKi:  0.300nM ΔG°:  -53.8kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
F. Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 120140BDBM120140(US8697708, 223)
Affinity DataKi:  0.400nM ΔG°:  -53.1kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
F. Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 120128BDBM120128(US8697708, 2)
Affinity DataKi:  0.5nM ΔG°:  -52.6kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
F. Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 120143BDBM120143(US8697708, 236)
Affinity DataKi:  0.5nM ΔG°:  -52.6kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
F. Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 120142BDBM120142(US8697708, 227)
Affinity DataKi:  0.800nM ΔG°:  -51.4kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
F. Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 120133BDBM120133(US8697708, 22)
Affinity DataKi:  1nM ΔG°:  -50.9kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
F. Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 120129BDBM120129(US8697708, 9)
Affinity DataKi:  1.40nM ΔG°:  -50.0kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
F. Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 120131BDBM120131(US8697708, 16)
Affinity DataKi:  1.40nM ΔG°:  -50.0kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
F. Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 120139BDBM120139(US8697708, 213)
Affinity DataKi:  1.5nM ΔG°:  -49.9kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
F. Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 120137BDBM120137(US8697708, 129)
Affinity DataKi:  1.60nM ΔG°:  -49.7kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
F. Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 120138BDBM120138(US8697708, 138)
Affinity DataKi:  4.10nM ΔG°:  -47.4kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
F. Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 120134BDBM120134(US8697708, 24)
Affinity DataKi:  6.20nM ΔG°:  -46.4kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
F. Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 120136BDBM120136(US8697708, 56)
Affinity DataKi:  8.60nM ΔG°:  -45.6kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
F. Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 120130BDBM120130(US8697708, 10)
Affinity DataKi:  23nM ΔG°:  -43.2kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
F. Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 120135BDBM120135(US8697708, 25)
Affinity DataKi:  87nM ΔG°:  -39.9kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent