Compile Data Set for Download or QSAR
Report error Found 147 Enz. Inhib. hit(s) with all data for entry = 3489
TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 402004BDBM402004(US10010547, Example 112 | 5-[[5-[4-[(1-isopropyl-4...)
Affinity DataIC50: 0.00400nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 402003BDBM402003(US10010547, Example 111 | 5-[[5-[4-[(1-ethyl-4-pip...)
Affinity DataIC50: 0.00500nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 402002BDBM402002(US10010547, Example 110 | 5-[[5-[2-methoxy-4-[(1-m...)
Affinity DataIC50: 0.00700nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 402035BDBM402035(US10010547, Example 145 | 5-[[5-[4-[(1-ethyl-4-pip...)
Affinity DataIC50: 0.00800nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 402036BDBM402036(US10010547, Example 146 | 5-[[5-[4-[(isobutylamino...)
Affinity DataIC50: 0.0120nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 401974BDBM401974(US10010547, Example 82 | 5-[[5-[2-methoxy-4-[(3R)-...)
Affinity DataIC50: 0.0160nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 401984BDBM401984(US10010547, Example 92 | 5-[[5-[4-[(3R)-3,4-dimeth...)
Affinity DataIC50: 0.0160nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 401985BDBM401985(US10010547, Example 93 | 5-[[5-[4-[(3R)-4-ethyl-3-...)
Affinity DataIC50: 0.0160nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 402031BDBM402031(US10010547, Example 141 | 5-[[5-[4-[[(3R)-1-isopro...)
Affinity DataIC50: 0.0190nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 402030BDBM402030(US10010547, Example 140 | 5-[[5-[4-[[(3R)-1-ethylp...)
Affinity DataIC50: 0.0210nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 402033BDBM402033(US10010547, Example 143 | 5-[[5-[4-[(1-ethyl-4-pip...)
Affinity DataIC50: 0.0210nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 401957BDBM401957(US10010547, Example 65 | 5-[[5-[2-methoxy-4-(1-met...)
Affinity DataIC50: 0.0220nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 402010BDBM402010(US10010547, Example 118 | 5-[[5-[2-methoxy-4-[(2R)...)
Affinity DataIC50: 0.0220nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 402018BDBM402018(US10010547, Example 128 | 5-[[5-[4-[[(2S)-1-ethylp...)
Affinity DataIC50: 0.0230nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 402020BDBM402020(US10010547, Example 130 | 5-[[5-[4-[(cyclopropylme...)
Affinity DataIC50: 0.0250nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 402034BDBM402034(US10010547, Example 144 | 5-[[5-[4-[(1-isopropyl-4...)
Affinity DataIC50: 0.0260nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 401906BDBM401906(US10010547, Example 14 | 5-[[5-[2-methoxy-4-[(tetr...)
Affinity DataIC50: 0.0260nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 401914BDBM401914(US10010547, Example 22 | 5-[[5-[2-methoxy-4-(4-met...)
Affinity DataIC50: 0.0260nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 402009BDBM402009(US10010547, Example 117 | 5-[[5-[2-methoxy-4-[(2R)...)
Affinity DataIC50: 0.0270nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 402029BDBM402029(US10010547, Example 139 | 5-[[5-[4-[[(3S)-1-isopro...)
Affinity DataIC50: 0.0270nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 402038BDBM402038(US10010547, Example 148 | 5-[[5-[4-[(1-isopropyl-4...)
Affinity DataIC50: 0.0310nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 401904BDBM401904(US10010547, Example 12 | 5-[5-(4-{[(1-cyclopropane...)
Affinity DataIC50: 0.0340nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 402028BDBM402028(US10010547, Example 138 | 5-[[5-[4-[[(3S)-1-ethylp...)
Affinity DataIC50: 0.0410nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 402000BDBM402000(US10010547, Example 108 | 5-[[5-[4-[(1-ethyl-4-pip...)
Affinity DataIC50: 0.0430nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 402017BDBM402017(US10010547, Example 127 | 5-[[5-[4-[[(2R)-1-isopro...)
Affinity DataIC50: 0.0440nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 402019BDBM402019(US10010547, Example 129 | 5-[[5-[4-[[(2S)-1-isopro...)
Affinity DataIC50: 0.0460nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 401903BDBM401903(US10010547, Example 11 | 5-{5-[2-methoxy-4-(1-meth...)
Affinity DataIC50: 0.0480nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 402027BDBM402027(US10010547, Example 137 | 5-[[5-[4-(4-isopropylpip...)
Affinity DataIC50: 0.0480nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 401981BDBM401981(US10010547, Example 89 | 5-[[5-[2-methoxy-4-[1-(2-...)
Affinity DataIC50: 0.0510nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 401955BDBM401955(US10010547, Example 63 | 5-[[5-[2-methoxy-4-[[meth...)
Affinity DataIC50: 0.0520nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 401992BDBM401992(US10010547, Example 100 | 5-[[5-[4-[[isopropyl(met...)
Affinity DataIC50: 0.0530nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 402026BDBM402026(US10010547, Example 136 | 5-[[5-[4-(4-ethylpiperaz...)
Affinity DataIC50: 0.0530nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 402025BDBM402025(US10010547, Example 135 | 5-[[5-[4-[(1-isopropyl-4...)
Affinity DataIC50: 0.0540nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 401938BDBM401938(US10010547, Example 46 | 5-[[5-(2-methoxy-4-pipera...)
Affinity DataIC50: 0.0540nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 401993BDBM401993(US10010547, Example 101 | 5-[[5-[2-methoxy-4-(pyrr...)
Affinity DataIC50: 0.0550nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 402016BDBM402016(US10010547, Example 126 | 5-[[5-[4-[[(2R)-1-ethylp...)
Affinity DataIC50: 0.0560nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 401982BDBM401982(US10010547, Example 90 | 5-[[5-[4-(ethylaminomethy...)
Affinity DataIC50: 0.0580nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 401900BDBM401900(US10010547, Example 8 | 5-(5-{4-[(4-fluoro-benzyla...)
Affinity DataIC50: 0.0580nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 401979BDBM401979(US10010547, Example 87 | 5-[[5-[4-(1-ethyl-3-fluor...)
Affinity DataIC50: 0.0590nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 401921BDBM401921(US10010547, Example 29 | 5-[[5-[2-methoxy-4-[(1-me...)
Affinity DataIC50: 0.0680nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 401951BDBM401951(US10010547, Example 59 | 5-[[5-[4-[(isopropylamino...)
Affinity DataIC50: 0.0710nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 401949BDBM401949(US10010547, Example 57 | 5-[[5-[2-methoxy-4-(4-pip...)
Affinity DataIC50: 0.0710nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 401925BDBM401925(US10010547, Example 33 | 5-[[5-[2-methoxy-4-[(3S)-...)
Affinity DataIC50: 0.0740nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 402008BDBM402008(US10010547, Example 116 | 5-[[5-(2-fluoro-6-methox...)
Affinity DataIC50: 0.0770nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 401901BDBM401901(US10010547, Example 9 | 5-(5-{2-methoxy-4-[(2-morp...)
Affinity DataIC50: 0.0770nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 401980BDBM401980(US10010547, Example 88 | 5-[[5-[4-(3-fluoro-1-isop...)
Affinity DataIC50: 0.0790nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 401999BDBM401999(US10010547, Example 107 | 5-[[5-[2-methoxy-4-[(1-m...)
Affinity DataIC50: 0.0810nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 402032BDBM402032(US10010547, Example 142 | 5-[[5-[4-(4-isobutylpipe...)
Affinity DataIC50: 0.0820nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 401954BDBM401954(US10010547, Example 62 | 2-[4-[4-[3-[(5-cyanopyraz...)
Affinity DataIC50: 0.0840nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 401908BDBM401908(US10010547, Example 16 | 5-[[5-[2-methoxy-4-(2-mor...)
Affinity DataIC50: 0.0850nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

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