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Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM402000
Substrate
n/a
Meas. Tech.
Kinase Inhibiting Activity Assay
IC50
0.043±n/a nM
Citation
 Boyle, RG; Walker, DW; Boyce, RJ; Peterson, S; Farouz, F; Vo, CH Pharmaceutical compounds US Patent  US10010547 Publication Date 7/3/2018 
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM402000
Synonyms:
5-[[5-[4-[(1-ethyl-4-piperidyl)methylamino]-2-methoxy-phenyl]-1H-pyrazol-3-yl]amino]pyrazine-2-carbonitrilehydrochloride | US10010547, Example 108 | US10973817, Example 108
Type:
Small organic molecule
Emp. Form.:
C23H28N8O
Mol. Mass.:
432.5214
SMILES:
CCN1CCC(CNc2ccc(-c3cc(Nc4cnc(cn4)C#N)n[nH]3)c(OC)c2)CC1
Structure:
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