TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataKi: 3.60nMAssay Description:Competitive inhibition of recombinant human G9a using biotinylated-Histone H3 peptide (1 to 21 residues) as substrate after 30 mins in presence of va...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataKi: 14nMAssay Description:Non-competitive inhibition of recombinant human G9a using biotinylated-Histone H3 peptide (1 to 21 residues) as substrate at varying concentration af...More data for this Ligand-Target Pair
Affinity DataKi: 2.00E+3nMAssay Description:Noncompetitive inhibition of P300 (unknown origin) using acetyl CoA as substrate after 15 mins by double reciprocal plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 9.40E+3nMAssay Description:Noncompetitive inhibition of P300 (unknown origin) using biotinylated H3 as substrate after 15 mins by double reciprocal plot analysisMore data for this Ligand-Target Pair
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate incubated for 20 mins in presence of [...More data for this Ligand-Target Pair
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Affinity DataIC50: 8.40nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate incubated for 20 mins in presence of [...More data for this Ligand-Target Pair
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Affinity DataIC50: 9.70nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate incubated for 20 mins in presence of [...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University Of Bologna
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of GSK3beta (unknown origin) pre-incubated for 30 mins followed by ULight-GS (Ser641/pSer657) peptide substrate addition and measured afte...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University Of Bologna
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of GSK3beta (unknown origin) pre-incubated for 30 mins followed by ULight-GS (Ser641/pSer657) peptide substrate addition and measured afte...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University Of Bologna
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of GSK3beta (unknown origin) pre-incubated for 30 mins followed by ULight-GS (Ser641/pSer657) peptide substrate addition and measured afte...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition G9a (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT1(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of GLP (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant human G9a using biotinylated-Histone H3 peptide (1 to 21 residues) after 30 mins in presence of SAM by AlphaLISA assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of recombinant human G9a using biotinylated-Histone H3 peptide (1 to 21 residues) after 30 mins in presence of SAM by AlphaLISA assayMore data for this Ligand-Target Pair
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:Inhibition of PRMT4 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Affinity DataIC50: 68nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate incubated for 20 mins in presence of [...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT1(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of GLP (unknown origin)More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Affinity DataIC50: 113nMAssay Description:Inhibition of human full length recombinant FLAG-tagged PRMT5 (2 to 637 residues) using histone H2A as substrate incubated for 20 mins in presence of...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition G9a (unknown origin)More data for this Ligand-Target Pair
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Affinity DataIC50: 176nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate incubated for 20 mins in presence of [...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 7(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Affinity DataIC50: 220nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT7 (2 to 692 residues) using GST-GAR as substrate incubated for 20 mins in presence of [3H]...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 7(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Affinity DataIC50: 226nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT7 (2 to 692 residues) using GST-GAR as substrate incubated for 20 mins in presence of [3H]...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 7(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Affinity DataIC50: 320nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT7 (2 to 692 residues) using GST-GAR as substrate incubated for 20 mins in presence of [3H]...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 1(Homo sapiens)
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:Inhibition of recombinant human PRMT1 assessed as residual activity using biotinylated histone H4 (1 to 21) as substrate incubated for 60 mins in pre...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 7(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Affinity DataIC50: 410nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT7 (2 to 692 residues) using GST-GAR as substrate incubated for 20 mins in presence of [3H]...More data for this Ligand-Target Pair
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Affinity DataIC50: 420nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate incubated for 20 mins in presence of [...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 7(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Affinity DataIC50: 550nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT7 (2 to 692 residues) using GST-GAR as substrate incubated for 20 mins in presence of [3H]...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 7(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Affinity DataIC50: 631nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT7 (2 to 692 residues) using GST-GAR as substrate incubated for 20 mins in presence of [3H]...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University Of Bologna
Curated by ChEMBL
Affinity DataIC50: 690nMAssay Description:Inhibition of GSK3beta (unknown origin) using GS-2 peptide substrate incubated for 30 mins by kinase-Glo luminescent assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT1(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 700nMAssay Description:Inhibition of recombinant human GLP (610 to 917 residues) using H3 peptide (1 to 20 residues) by mass spectrometryMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Affinity DataIC50: 778nMAssay Description:Inhibition of human full length recombinant FLAG-tagged PRMT5 (2 to 637 residues) using histone H2A as substrate incubated for 20 mins in presence of...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 1(Homo sapiens)
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Affinity DataIC50: 835nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT1 (2 to 371 residues) using histone H4 as substrate incubated for 20 mins in presence of [...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 1(Homo sapiens)
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Affinity DataIC50: 860nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT1 (2 to 371 residues) using histone H4 as substrate incubated for 20 mins in presence of [...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University Of Bologna
Curated by ChEMBL
Affinity DataIC50: 890nMAssay Description:Inhibition of GSK3beta (unknown origin) using GS-2 peptide substrate incubated for 30 mins by kinase-Glo luminescent assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 955nMAssay Description:Inhibition of recombinant human G9a using biotinylated-Histone H3 peptide (1 to 21 residues) after 30 mins in presence of SAM by AlphaLISA assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 1.09E+3nMAssay Description:Inhibition of recombinant human G9a using biotinylated-Histone H3 peptide (1 to 21 residues) after 30 mins in presence of SAM by AlphaLISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of recombinant CBP (unknown origin)More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 1(Homo sapiens)
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of recombinant human PRMT1 assessed as residual activity using biotinylated histone H4 (1 to 21) as substrate incubated for 60 mins in pre...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Affinity DataIC50: 1.41E+3nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT8 (61 to 394 residues) using histone H4 as substrate incubated for 20 mins in presence of ...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University Of Bologna
Curated by ChEMBL
Affinity DataIC50: 1.42E+3nMAssay Description:Inhibition of GSK3beta (unknown origin) using GS-2 peptide substrate incubated for 30 mins by kinase-Glo luminescent assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Affinity DataIC50: 1.46E+3nMAssay Description:Inhibition of human full length recombinant FLAG-tagged PRMT5 (2 to 637 residues) using histone H2A as substrate incubated for 20 mins in presence of...More data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of P300 (unknown origin) using histone H3/[acetyl-3H]-acetyl coenzyme A as substrateMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition G9a (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of P300 (unknown origin) using histone H3/[acetyl-3H]-acetyl coenzyme A as substrateMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT1(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of GLP (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of P300 (unknown origin) using histone H3/[acetyl-3H]-acetyl coenzyme A as substrateMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 1(Homo sapiens)
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of recombinant human PRMT1 assessed as residual activity using biotinylated histone H4 (1 to 21) as substrate incubated for 60 mins in pre...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 7(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Affinity DataIC50: 1.68E+3nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT7 (2 to 692 residues) using GST-GAR as substrate incubated for 20 mins in presence of [3H]...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 6(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Affinity DataIC50: 1.75E+3nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT6 (2 to 375 residues) using GST-GAR as substrate incubated for 20 mins in presence of [3H]...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 1(Homo sapiens)
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire
Curated by ChEMBL
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT1 (2 to 371 residues) using histone H4 as substrate incubated for 20 mins in presence of [...More data for this Ligand-Target Pair