Compile Data Set for Download or QSAR
maximum 50k data
Found 2881 with Last Name = 'shu' and Initial = 'j'
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50379086(CHEMBL2012521 | CHEMBL2012522 | LY-377604)
Affinity DataKi:  0.0120nMAssay Description:Displacement of [125I]Iodocyanopindolol from human adrenergic beta2 receptor expressed in insect sf9 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50379086(CHEMBL2012521 | CHEMBL2012522 | LY-377604)
Affinity DataKi:  0.0230nMAssay Description:Displacement of [125I]Iodocyanopindolol from human adrenergic beta1 receptor expressed in insect sf9 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16318(3-({5-cyano-6-[(2,2-dimethylpropyl)(methyl)amino]-...)
Affinity DataKi:  0.0470nM ΔG°:  -58.4kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16319(3-({2-amino-5-cyano-6-[(2,2-dimethylpropyl)(methyl...)
Affinity DataKi:  0.0500nM ΔG°:  -58.2kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16329(3-({2-amino-5-cyano-6-[(1-methylethyl)amino]pyrimi...)
Affinity DataKi:  0.0570nM ΔG°:  -57.9kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16317(3-({5-cyano-6-[(2,2-dimethylpropyl)(methyl)amino]-...)
Affinity DataKi:  0.0570nM ΔG°:  -57.9kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16320(3-({5-cyano-6-[(2,2-dimethylpropyl)(methyl)amino]p...)
Affinity DataKi:  0.150nM ΔG°:  -55.5kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16330(3-{[2-amino-5-cyano-6-(cyclopentylamino)pyrimidin-...)
Affinity DataKi:  0.160nM ΔG°:  -55.3kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM21281((11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphth...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity of compound was determined against to human cannabinoid receptor 2 in chinese hamster ovary cellsMore data for this Ligand-Target Pair
TargetSubstance-P receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50177371(2-((R)-4-(((R)-1-(3,5-bis(trifluoromethyl)phenyl)e...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50177376(4-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-4-(4...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16325(3-({5-cyano-6-[(1-methylethyl)amino]pyrimidin-4-yl...)
Affinity DataKi:  0.410nM ΔG°:  -53.0kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16324(3-{[5-cyano-6-(cyclopentylamino)pyrimidin-4-yl]ami...)
Affinity DataKi:  0.420nM ΔG°:  -53.0kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50376456(CHEMBL262592)
Affinity DataKi:  0.420nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50376433(CHEMBL258895)
Affinity DataKi:  0.440nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50376434(CHEMBL408150)
Affinity DataKi:  0.460nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
TargetSubstance-P receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50177385((R)-4-(((R)-1-(3,5-bis(trifluoromethyl)phenyl)etho...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50376435(CHEMBL261845)
Affinity DataKi:  0.540nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50177387((R)-4-(((R)-1-(3,5-bis(trifluoromethyl)phenyl)etho...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16323(3-({5-cyano-6-[(1-methylethyl)amino]pyrimidin-4-yl...)
Affinity DataKi:  0.610nM ΔG°:  -52.1kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50177379((R)-4-(((R)-1-(3,5-bis(trifluoromethyl)phenyl)etho...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50120186(2-(1-Benzyl-piperidin-4-ylamino)-1-[(S)-2-(3,4-dic...)
Affinity DataKi:  0.900nMAssay Description:Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50177386(4-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-4-(4...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50120182(CHEMBL107469 | N-[4-(4-{2-[(R)-2-(3,4-Dichloro-phe...)
Affinity DataKi:  0.900nMAssay Description:Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]-NKA as the radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16322(3-{[5-cyano-6-(propylamino)pyrimidin-4-yl]amino}-N...)
Affinity DataKi:  0.970nM ΔG°:  -50.9kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50376432(CHEMBL258748)
Affinity DataKi:  0.980nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50272598(6-Methoxy-5-(2-morpholin-4-yl-ethyl)-2-(1,3,3-trim...)
Affinity DataKi:  1nMAssay Description:Binding affinity against human cannabinoid receptor 2 in chinese hamster ovary cells using WIN-55212-2 mesylate[57-3H]More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50120172((R)-2-Amino-1-(4-{2-[(R)-2-(3,4-dichloro-phenyl)-4...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]-NKA as the radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50120173((S)-2-Amino-1-(4-{2-[(R)-2-(3,4-dichloro-phenyl)-4...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]-NKA as the radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM286984(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Affinity DataKi:  1.30nMAssay Description:Irreversible inhibition of human FGFR2 preincubated with enzyme followed by peptide substrate addition by caliper capillary electrophoresis methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50120181(CHEMBL108997 | N-[4-(4-{2-[(R)-2-(3,4-Dichloro-phe...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]-NKA as the radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50120204(1-[(R)-2-(3,4-Dichloro-phenyl)-4-(3,5-dimethyl-ben...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]-NKA as the radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16331(3-({2-amino-5-cyano-6-[(1-methylethyl)amino]pyrimi...)
Affinity DataKi:  1.5nM ΔG°:  -49.9kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50177384((R)-4-(((R)-1-(3,5-bis(trifluoromethyl)phenyl)etho...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16326(3-{[5-cyano-6-(cyclopentylamino)pyrimidin-4-yl]ami...)
Affinity DataKi:  1.60nM ΔG°:  -49.7kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50177383(4-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-4-(4...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM286984(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Affinity DataKi:  1.60nMAssay Description:Irreversible inhibition of human FGFR1 using 5-FAM-KKKKEEIYFFF-NH2 as substrate preincubated with enzyme followed by peptide substrate addition by ca...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50177380((R)-4-(((R)-1-(3,5-bis(trifluoromethyl)phenyl)etho...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50120180(2-(1-Benzyl-piperidin-4-ylamino)-1-[2-(3,4-dichlor...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50120202(2-(1-Benzyl-piperidin-4-ylamino)-1-[(S)-4-(3,5-bis...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16332(3-{[2-amino-5-cyano-6-(cyclopentylamino)pyrimidin-...)
Affinity DataKi:  1.90nM ΔG°:  -49.3kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM21281((11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphth...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity of compound was determined against to human cannabinoid receptor 1 in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50128092(7-Methoxy-1-(2-morpholin-4-yl-ethyl)-1H-indazole-3...)
Affinity DataKi:  2nMAssay Description:Binding affinity against human cannabinoid receptor 2 in chinese hamster ovary cells using WIN-55212-2 mesylate[57-3H]More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM286984(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Affinity DataKi:  2.20nMAssay Description:Irreversible inhibition of human FGFR3 preincubated with enzyme followed by peptide substrate addition by caliper capillary electrophoresis methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50177375((R)-4-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-...)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50120176(1-[(R)-2-(3,4-Dichloro-phenyl)-4-(3,5-dimethyl-ben...)
Affinity DataKi:  3nMAssay Description:Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]-NKA as the radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50177370((R)-4-(((R)-1-(3,5-bis(trifluoromethyl)phenyl)etho...)
Affinity DataKi:  3.10nMAssay Description:Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50120205((S)-2-Amino-1-(4-{2-[(R)-2-(3,4-dichloro-phenyl)-4...)
Affinity DataKi:  3.20nMAssay Description:Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]-NKA as the radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50120184(2-(1-Benzyl-piperidin-4-ylamino)-1-[4-(3,5-dibromo...)
Affinity DataKi:  3.20nMAssay Description:Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50120183(2-(1-Benzyl-piperidin-4-ylamino)-1-[(R)-2-(3,4-dic...)
Affinity DataKi:  3.40nMAssay Description:Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]-NKA as the radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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