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Patent code US10377753

Compile Data Set for Download or QSAR

Found 634 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409275
PNG
(2-[6-(4-Fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyrid...)
Show SMILES CN(C)C(=O)Cn1ccc2ncc(cc12)-c1ccc(F)c(C)c1
Show InChI InChI=1S/C18H18FN3O/c1-12-8-13(4-5-15(12)19)14-9-17-16(20-10-14)6-7-22(17)11-18(23)21(2)3/h4-10H,11H2,1-3H3
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n/an/a 2n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409513
PNG
(2-[6-(5-Chloro-2-thienyl)pyrrolo[3,2-b]pyridin-1-y...)
Show SMILES CN(C)C(=O)Cn1ccc2ncc(cc12)-c1ccc(Cl)s1
Show InChI InChI=1S/C15H14ClN3OS/c1-18(2)15(20)9-19-6-5-11-12(19)7-10(8-17-11)13-3-4-14(16)21-13/h3-8H,9H2,1-2H3
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n/an/a 6.31n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409512
PNG
(2-[6-[3-(Difluoromethyl)phenyl]pyrrolo[3,2-b]pyrid...)
Show SMILES CN(C)C(=O)Cn1ccc2ncc(cc12)-c1cccc(c1)C(F)F
Show InChI InChI=1S/C18H17F2N3O/c1-22(2)17(24)11-23-7-6-15-16(23)9-14(10-21-15)12-4-3-5-13(8-12)18(19)20/h3-10,18H,11H2,1-2H3
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n/an/a 10n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409623
PNG
(2-[6-(3-Chlorophenyl)-3-fluoro-pyrrolo[3,2-b]pyrid...)
Show SMILES FC1CN(C1)C(=O)Cn1cc(F)c2ncc(cc12)-c1cccc(Cl)c1
Show InChI InChI=1S/C18H14ClF2N3O/c19-13-3-1-2-11(4-13)12-5-16-18(22-6-12)15(21)9-23(16)10-17(25)24-7-14(20)8-24/h1-6,9,14H,7-8,10H2
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n/an/a 10n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409515
PNG
(1-(Azetidin-1-yl)-2-[6-(5-methyl-2-thienyl)pyrrolo...)
Show SMILES Cc1ccc(s1)-c1cnc2ccn(CC(=O)N3CCC3)c2c1
Show InChI InChI=1S/C17H17N3OS/c1-12-3-4-16(22-12)13-9-15-14(18-10-13)5-8-20(15)11-17(21)19-6-2-7-19/h3-5,8-10H,2,6-7,11H2,1H3
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n/an/a 10n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409743
PNG
(2-[6-(3,5-Difluorophenyl)-3-(trifluoromethyl)pyrro...)
Show SMILES CN(C)C(=O)Cn1cc(c2ncc(cc12)-c1cc(F)cc(F)c1)C(F)(F)F
Show InChI InChI=1S/C18H14F5N3O/c1-25(2)16(27)9-26-8-14(18(21,22)23)17-15(26)5-11(7-24-17)10-3-12(19)6-13(20)4-10/h3-8H,9H2,1-2H3
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n/an/a 10n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409735
PNG
(2-[3-Chloro-6-(5-chloro-4-methyl-2-thienyl)pyrrolo...)
Show SMILES CN(C)C(=O)Cn1cc(Cl)c2ncc(cc12)-c1cc(C)c(Cl)s1
Show InChI InChI=1S/C16H15Cl2N3OS/c1-9-4-13(23-16(9)18)10-5-12-15(19-6-10)11(17)7-21(12)8-14(22)20(2)3/h4-7H,8H2,1-3H3
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n/an/a 10n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409638
PNG
(2-[6-(3-Chloro-4-fluoro-phenyl)-3-fluoro-pyrrolo[3...)
Show SMILES CN(C)C(=O)Cn1cc(F)c2ncc(cc12)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C17H14ClF2N3O/c1-22(2)16(24)9-23-8-14(20)17-15(23)6-11(7-21-17)10-3-4-13(19)12(18)5-10/h3-8H,9H2,1-2H3
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n/an/a 12.6n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409670
PNG
(2-[3-Chloro-6-(3,5-difluorophenyl)pyrrolo[3,2-b]py...)
Show SMILES FC1CN(C1)C(=O)Cn1cc(Cl)c2ncc(cc12)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C18H13ClF3N3O/c19-15-8-24(9-17(26)25-6-14(22)7-25)16-3-11(5-23-18(15)16)10-1-12(20)4-13(21)2-10/h1-5,8,14H,6-7,9H2
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n/an/a 12.6n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409470
PNG
(1-[3-Fluoro-6-(4-fluoro-3-methyl-phenyl)pyrrolo[3,...)
Show SMILES CCC(=O)Cn1cc(F)c2ncc(cc12)-c1ccc(F)c(C)c1
Show InChI InChI=1S/C18H16F2N2O/c1-3-14(23)9-22-10-16(20)18-17(22)7-13(8-21-18)12-4-5-15(19)11(2)6-12/h4-8,10H,3,9H2,1-2H3
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n/an/a 12.6n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409678
PNG
(2-[3-Chloro-6-(3-chlorophenyl)pyrrolo[3,2-b]pyridi...)
Show SMILES FC1CN(C1)C(=O)Cn1cc(Cl)c2ncc(cc12)-c1cccc(Cl)c1
Show InChI InChI=1S/C18H14Cl2FN3O/c19-13-3-1-2-11(4-13)12-5-16-18(22-6-12)15(20)9-23(16)10-17(25)24-7-14(21)8-24/h1-6,9,14H,7-8,10H2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409618
PNG
(1-(3-Fluoroazetidin-1-yl)-2-[3-fluoro-6-[3- | US10...)
Show SMILES FC1CN(C1)C(=O)Cn1cc(F)c2ncc(cc12)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C19H14F5N3O/c20-14-7-27(8-14)17(28)10-26-9-15(21)18-16(26)5-12(6-25-18)11-2-1-3-13(4-11)19(22,23)24/h1-6,9,14H,7-8,10H2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409475
PNG
(4-[6-(4-Fluorophenyl)pyrrolo[3,2-b]pyridin-1-yl]bu...)
Show SMILES CC(=O)CCn1ccc2ncc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C17H15FN2O/c1-12(21)6-8-20-9-7-16-17(20)10-14(11-19-16)13-2-4-15(18)5-3-13/h2-5,7,9-11H,6,8H2,1H3
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n/an/a 12.6n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409510
PNG
(N,N-Dimethyl-2-[6-(3,4,5-trifluorophenyl)pyrrolo[3...)
Show SMILES CN(C)C(=O)Cn1ccc2ncc(cc12)-c1cc(F)c(F)c(F)c1
Show InChI InChI=1S/C17H14F3N3O/c1-22(2)16(24)9-23-4-3-14-15(23)7-11(8-21-14)10-5-12(18)17(20)13(19)6-10/h3-8H,9H2,1-2H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409474
PNG
(1-[3-Fluoro-6-(4-methyl-2-thienyl)pyrrolo[3,2-b]py...)
Show SMILES CCC(=O)Cn1cc(F)c2ncc(cc12)-c1cc(C)cs1
Show InChI InChI=1S/C16H15FN2OS/c1-3-12(20)7-19-8-13(17)16-14(19)5-11(6-18-16)15-4-10(2)9-21-15/h4-6,8-9H,3,7H2,1-2H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409598
PNG
(N-Ethyl-2-[6-[2-fluoro-3-(trifluoromethyl)phenyl]p...)
Show SMILES CCN(C)C(=O)Cn1ccc2ncc(cc12)-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C19H17F4N3O/c1-3-25(2)17(27)11-26-8-7-15-16(26)9-12(10-24-15)13-5-4-6-14(18(13)20)19(21,22)23/h4-10H,3,11H2,1-2H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409629
PNG
(2-(3-Fluoro-6-phenyl-pyrrolo[3,2-b]pyridin-1-yl)-N...)
Show SMILES CN(C)C(=O)Cn1cc(F)c2ncc(cc12)-c1ccccc1
Show InChI InChI=1S/C17H16FN3O/c1-20(2)16(22)11-21-10-14(18)17-15(21)8-13(9-19-17)12-6-4-3-5-7-12/h3-10H,11H2,1-2H3
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n/an/a 12.6n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409755
PNG
(2-[6-(3,5-Difluorophenyl)-3-methyl-pyrrolo[3,2-b]p...)
Show SMILES Cc1cn(CC(=O)N2CCCC2)c2cc(cnc12)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C20H19F2N3O/c1-13-11-25(12-19(26)24-4-2-3-5-24)18-8-15(10-23-20(13)18)14-6-16(21)9-17(22)7-14/h6-11H,2-5,12H2,1H3
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n/an/a 15.8n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409640
PNG
(1-(Azetidin-1-yl)-2-[3-fluoro-6-(3-fluorophenyl)py...)
Show SMILES Fc1cn(CC(=O)N2CCC2)c2cc(cnc12)-c1cccc(F)c1
Show InChI InChI=1S/C18H15F2N3O/c19-14-4-1-3-12(7-14)13-8-16-18(21-9-13)15(20)10-23(16)11-17(24)22-5-2-6-22/h1,3-4,7-10H,2,5-6,11H2
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n/an/a 15.8n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409507
PNG
(2-[6-(5-Chloro-2-thienyl)pyrrolo[3,2-b]pyridin-1-y...)
Show SMILES FC1CN(C1)C(=O)Cn1ccc2ncc(cc12)-c1ccc(Cl)s1
Show InChI InChI=1S/C16H13ClFN3OS/c17-15-2-1-14(23-15)10-5-13-12(19-6-10)3-4-20(13)9-16(22)21-7-11(18)8-21/h1-6,11H,7-9H2
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n/an/a 15.8n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409506
PNG
(1-(3-Fluoroazetidin-1-yl)-2-[6-(3,4,5-trifluorophe...)
Show SMILES FC1CN(C1)C(=O)Cn1ccc2ncc(cc12)-c1cc(F)c(F)c(F)c1
Show InChI InChI=1S/C18H13F4N3O/c19-12-7-25(8-12)17(26)9-24-2-1-15-16(24)5-11(6-23-15)10-3-13(20)18(22)14(21)4-10/h1-6,12H,7-9H2
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n/an/a 15.8n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409518
PNG
(1-(Azetidin-1-yl)-2-[3-fluoro-6-(3,4,5-trifluoroph...)
Show SMILES Fc1cn(CC(=O)N2CCC2)c2cc(cnc12)-c1cc(F)c(F)c(F)c1
Show InChI InChI=1S/C18H13F4N3O/c19-12-4-10(5-13(20)17(12)22)11-6-15-18(23-7-11)14(21)8-25(15)9-16(26)24-2-1-3-24/h4-8H,1-3,9H2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409602
PNG
(2-[6-(3-Chloro-4-fluoro-phenyl)pyrrolo[3,2-b]pyrid...)
Show SMILES CN(C)C(=O)Cn1ccc2ncc(cc12)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C17H15ClFN3O/c1-21(2)17(23)10-22-6-5-15-16(22)8-12(9-20-15)11-3-4-14(19)13(18)7-11/h3-9H,10H2,1-2H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409622
PNG
(2-[6-(2,4-Difluoro-3-methyl-phenyl)-3-fluoro-pyrro...)
Show SMILES Cc1c(F)ccc(-c2cnc3c(F)cn(CC(=O)N4CC(F)C4)c3c2)c1F
Show InChI InChI=1S/C19H15F4N3O/c1-10-14(21)3-2-13(18(10)23)11-4-16-19(24-5-11)15(22)8-25(16)9-17(27)26-6-12(20)7-26/h2-5,8,12H,6-7,9H2,1H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409637
PNG
(2-[6-(3-Chlorophenyl)-3-fluoro-pyrrolo[3,2-b]pyrid...)
Show SMILES CN(C)C(=O)Cn1cc(F)c2ncc(cc12)-c1cccc(Cl)c1
Show InChI InChI=1S/C17H15ClFN3O/c1-21(2)16(23)10-22-9-14(19)17-15(22)7-12(8-20-17)11-4-3-5-13(18)6-11/h3-9H,10H2,1-2H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409485
PNG
(N-Cyclopropyl-2-[6-(3,5-difluorophenyl)pyrrolo[3,2...)
Show SMILES Fc1cc(F)cc(c1)-c1cnc2ccn(CC(=O)NC3CC3)c2c1
Show InChI InChI=1S/C18H15F2N3O/c19-13-5-11(6-14(20)8-13)12-7-17-16(21-9-12)3-4-23(17)10-18(24)22-15-1-2-15/h3-9,15H,1-2,10H2,(H,22,24)
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409516
PNG
(1-(Azetidin-1-yl)-2-[3-chloro-6-(5-chloro-2-thieny...)
Show SMILES Clc1ccc(s1)-c1cnc2c(Cl)cn(CC(=O)N3CCC3)c2c1
Show InChI InChI=1S/C16H13Cl2N3OS/c17-11-8-21(9-15(22)20-4-1-5-20)12-6-10(7-19-16(11)12)13-2-3-14(18)23-13/h2-3,6-8H,1,4-5,9H2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409603
PNG
(2-[6-(2,4-Difluoro-3-methyl-phenyl)pyrrolo[3,2-b]p...)
Show SMILES CCN(C)C(=O)Cn1ccc2ncc(cc12)-c1ccc(F)c(C)c1F
Show InChI InChI=1S/C19H19F2N3O/c1-4-23(3)18(25)11-24-8-7-16-17(24)9-13(10-22-16)14-5-6-15(20)12(2)19(14)21/h5-10H,4,11H2,1-3H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409091
PNG
(2-[3-Chloro-6-(3,4-difluorophenyl)pyrrolo[3,2-b]py...)
Show SMILES Fc1ccc(cc1F)-c1cnc2c(Cl)cn(CC(=O)N3CC(F)(F)C3)c2c1
Show InChI InChI=1S/C18H12ClF4N3O/c19-12-6-25(7-16(27)26-8-18(22,23)9-26)15-4-11(5-24-17(12)15)10-1-2-13(20)14(21)3-10/h1-6H,7-9H2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409517
PNG
(1-(Azetidin-1-yl)-2-[6-(3,4-difluorophenyl)-3-fluo...)
Show SMILES Fc1cn(CC(=O)N2CCC2)c2cc(cnc12)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C18H14F3N3O/c19-13-3-2-11(6-14(13)20)12-7-16-18(22-8-12)15(21)9-24(16)10-17(25)23-4-1-5-23/h2-3,6-9H,1,4-5,10H2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409625
PNG
(2-[6-(3-Ethylphenyl)-3-fluoro-pyrrolo[3,2-b]pyridi...)
Show SMILES CCc1cccc(c1)-c1cnc2c(F)cn(CC(=O)N3CC(F)C3)c2c1
Show InChI InChI=1S/C20H19F2N3O/c1-2-13-4-3-5-14(6-13)15-7-18-20(23-8-15)17(22)11-24(18)12-19(26)25-9-16(21)10-25/h3-8,11,16H,2,9-10,12H2,1H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409591
PNG
(1-(3-Fluoroazetidin-1-yl)-2-[6-(2-fluorophenyl)pyr...)
Show SMILES FC1CN(C1)C(=O)Cn1ccc2ncc(cc12)-c1ccccc1F
Show InChI InChI=1S/C18H15F2N3O/c19-13-9-23(10-13)18(24)11-22-6-5-16-17(22)7-12(8-21-16)14-3-1-2-4-15(14)20/h1-8,13H,9-11H2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409616
PNG
(1-(3-Fluoroazetidin-1-yl)-2-(3-fluoro-6-phenyl-pyr...)
Show SMILES FC1CN(C1)C(=O)Cn1cc(F)c2ncc(cc12)-c1ccccc1
Show InChI InChI=1S/C18H15F2N3O/c19-14-8-23(9-14)17(24)11-22-10-15(20)18-16(22)6-13(7-21-18)12-4-2-1-3-5-12/h1-7,10,14H,8-9,11H2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409472
PNG
(1-[6-[3-(Difluoromethyl)phenyl]-3-fluoro-pyrrolo[3...)
Show SMILES CCC(=O)Cn1cc(F)c2ncc(cc12)-c1cccc(c1)C(F)F
Show InChI InChI=1S/C18H15F3N2O/c1-2-14(24)9-23-10-15(19)17-16(23)7-13(8-22-17)11-4-3-5-12(6-11)18(20)21/h3-8,10,18H,2,9H2,1H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409473
PNG
(1-[6-(5-Chloro-2-thienyl)-3-fluoro-pyrrolo[3,2-b]p...)
Show SMILES CCC(=O)Cn1cc(F)c2ncc(cc12)-c1ccc(Cl)s1
Show InChI InChI=1S/C15H12ClFN2OS/c1-2-10(20)7-19-8-11(17)15-12(19)5-9(6-18-15)13-3-4-14(16)21-13/h3-6,8H,2,7H2,1H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409237
PNG
(6-(4-Methyl-2-thienyl)-1-[[5-(trifluoromethyl)-2- ...)
Show SMILES Cc1csc(c1)-c1cnc2ccn(Cc3ccc(o3)C(F)(F)F)c2c1
Show InChI InChI=1S/C18H13F3N2OS/c1-11-6-16(25-10-11)12-7-15-14(22-8-12)4-5-23(15)9-13-2-3-17(24-13)18(19,20)21/h2-8,10H,9H2,1H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409074
PNG
(1-(Azetidin-1-yl)-2-[3-bromo-6-(4-fluorophenyl)pyr...)
Show SMILES Fc1ccc(cc1)-c1cnc2c(Br)cn(CC(=O)N3CCC3)c2c1
Show InChI InChI=1S/C18H15BrFN3O/c19-15-10-23(11-17(24)22-6-1-7-22)16-8-13(9-21-18(15)16)12-2-4-14(20)5-3-12/h2-5,8-10H,1,6-7,11H2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409500
PNG
(1-Cyclobutyl-2-[6-(4-fluorophenyl)pyrrolo[3,2-b]py...)
Show SMILES Fc1ccc(cc1)-c1cnc2ccn(CC(=O)C3CCC3)c2c1
Show InChI InChI=1S/C19H17FN2O/c20-16-6-4-13(5-7-16)15-10-18-17(21-11-15)8-9-22(18)12-19(23)14-2-1-3-14/h4-11,14H,1-3,12H2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409508
PNG
(1-(Azetidin-1-yl)-2-[6-(5-chloro-2-thienyl)pyrrolo...)
Show SMILES Clc1ccc(s1)-c1cnc2ccn(CC(=O)N3CCC3)c2c1
Show InChI InChI=1S/C16H14ClN3OS/c17-15-3-2-14(22-15)11-8-13-12(18-9-11)4-7-20(13)10-16(21)19-5-1-6-19/h2-4,7-9H,1,5-6,10H2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409409
PNG
(2-[6-(5-Ethyl-2-thienyl)pyrrolo[3,2-b]pyridin-1-yl...)
Show SMILES CCc1ccc(s1)-c1cnc2ccn(CC(=O)N3CC(F)C3)c2c1
Show InChI InChI=1S/C18H18FN3OS/c1-2-14-3-4-17(24-14)12-7-16-15(20-8-12)5-6-21(16)11-18(23)22-9-13(19)10-22/h3-8,13H,2,9-11H2,1H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409431
PNG
(2-(3-Chloro-6-phenyl-pyrrolo[3,2-b]pyridin-1-yl)-1...)
Show SMILES Clc1cn(CC(=O)C2CC2)c2cc(cnc12)-c1ccccc1
Show InChI InChI=1S/C18H15ClN2O/c19-15-10-21(11-17(22)13-6-7-13)16-8-14(9-20-18(15)16)12-4-2-1-3-5-12/h1-5,8-10,13H,6-7,11H2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409432
PNG
(1-(Azetidin-1-yl)-2-[3-chloro-6-(3,4,5-trifluoroph...)
Show SMILES Fc1cc(cc(F)c1F)-c1cnc2c(Cl)cn(CC(=O)N3CCC3)c2c1
Show InChI InChI=1S/C18H13ClF3N3O/c19-12-8-25(9-16(26)24-2-1-3-24)15-6-11(7-23-18(12)15)10-4-13(20)17(22)14(21)5-10/h4-8H,1-3,9H2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409450
PNG
(2-[6-(5-Chloro-2-thienyl)-3-fluoro-pyrrolo[3,2-b]p...)
Show SMILES Fc1cn(CC(=O)C2CC2)c2cc(cnc12)-c1ccc(Cl)s1
Show InChI InChI=1S/C16H12ClFN2OS/c17-15-4-3-14(22-15)10-5-12-16(19-6-10)11(18)7-20(12)8-13(21)9-1-2-9/h3-7,9H,1-2,8H2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409492
PNG
(1-(Azetidin-1-yl)-2-[6-(3,4-dichlorophenyl)pyrrolo...)
Show SMILES Clc1ccc(cc1Cl)-c1cnc2ccn(CC(=O)N3CCC3)c2c1
Show InChI InChI=1S/C18H15Cl2N3O/c19-14-3-2-12(8-15(14)20)13-9-17-16(21-10-13)4-7-23(17)11-18(24)22-5-1-6-22/h2-4,7-10H,1,5-6,11H2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409519
PNG
(2-[3-Chloro-6-(4-fluorophenyl)pyrrolo[3,2-b]pyridi...)
Show SMILES Fc1ccc(cc1)-c1cnc2c(Cl)cn(CC(=O)C3CC3)c2c1
Show InChI InChI=1S/C18H14ClFN2O/c19-15-9-22(10-17(23)12-1-2-12)16-7-13(8-21-18(15)16)11-3-5-14(20)6-4-11/h3-9,12H,1-2,10H2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409624
PNG
(2-[6-(3-Chloro-2-fluoro-phenyl)-3-fluoro-pyrrolo[3...)
Show SMILES FC1CN(C1)C(=O)Cn1cc(F)c2ncc(cc12)-c1cccc(Cl)c1F
Show InChI InChI=1S/C18H13ClF3N3O/c19-13-3-1-2-12(17(13)22)10-4-15-18(23-5-10)14(21)8-24(15)9-16(26)25-6-11(20)7-25/h1-5,8,11H,6-7,9H2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409581
PNG
(2-[6-(2,4-Difluoro-3-methyl-phenyl)pyrrolo[3,2-b]p...)
Show SMILES CN(C)C(=O)Cn1ccc2ncc(cc12)-c1ccc(F)c(C)c1F
Show InChI InChI=1S/C18H17F2N3O/c1-11-14(19)5-4-13(18(11)20)12-8-16-15(21-9-12)6-7-23(16)10-17(24)22(2)3/h4-9H,10H2,1-3H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409193
PNG
(1-Pyrrolidin-1-yl-2-[6-(3,4,5-trifluorophenyl)pyrr...)
Show SMILES Fc1cc(cc(F)c1F)-c1cnc2ccn(CC(=O)N3CCCC3)c2c1
Show InChI InChI=1S/C19H16F3N3O/c20-14-7-12(8-15(21)19(14)22)13-9-17-16(23-10-13)3-6-25(17)11-18(26)24-4-1-2-5-24/h3,6-10H,1-2,4-5,11H2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409453
PNG
(1-Cyclopropyl-2-[6-[3-(difluoromethyl)phenyl]-3-fl...)
Show SMILES FC(F)c1cccc(c1)-c1cnc2c(F)cn(CC(=O)C3CC3)c2c1
Show InChI InChI=1S/C19H15F3N2O/c20-15-9-24(10-17(25)11-4-5-11)16-7-14(8-23-18(15)16)12-2-1-3-13(6-12)19(21)22/h1-3,6-9,11,19H,4-5,10H2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM409676
PNG
(2-[3-Chloro-6-(3-fluorophenyl)pyrrolo[3,2-b]pyridi...)
Show SMILES FC1CN(C1)C(=O)Cn1cc(Cl)c2ncc(cc12)-c1cccc(F)c1
Show InChI InChI=1S/C18H14ClF2N3O/c19-15-9-23(10-17(25)24-7-14(21)8-24)16-5-12(6-22-18(15)16)11-2-1-3-13(20)4-11/h1-6,9,14H,7-8,10H2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...

US Patent US10377753 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GVK
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%