Target
Mu-type opioid receptor
Ligand
BDBM327442
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
4.10±n/a nM
Citation
 Taniko, KMiyazawa, TKaneko, TKurumazuka, DHarada, SIzuchi, TOkabe, MIwamura, RTsuzaki, YSetoguchi, HImura, YAkaza, HShimizu, MKimura, T 3-azabicyclo[3.1.0]hexane derivative and use thereof for medical purpose US Patent  US9663463 Publication Date 5/30/2017 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM327442
Synonyms:
N-(3-{(1R,5S,6r)-3-[(5,6-difluoro-2-hydroxy-2,3-dihydro-1H-inden-2-yl)methyl]-6-ethyl-3-azabicyclo[3.1.0]hexan-6-yl}phenyl)cyclopropanesulfonamide | US9663463, 20-(a)
Type:
Small organic molecule
Emp. Form.:
C26H30F2N2O3S
Mol. Mass.:
488.59
SMILES:
CCC1([C@H]2CN(CC3(O)Cc4cc(F)c(F)cc4C3)C[C@@H]12)c1cccc(NS(=O)(=O)C2CC2)c1
Structure:
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