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Target
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Ligand
BDBM347370
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
>7500±n/a nM
Citation
 Markowitz, S; Willson, JK; Posner, BA; Ready, J; Zhang, Y; Tai, H; Antczak, M; Gerson, S; Bae, K; Yang, SY; Desai, A Compositions and methods of modulating 15-PGDH activity US Patent  US9790233 Publication Date 10/17/2017 
Target
Name:
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Synonyms:
15-PGDH | 15-hydroxyprostaglandin dehydrogenase [NAD+] | HPGD | PGDH1 | PGDH_HUMAN | Prostaglandin dehydrogenase 1 (15-PGDH) | SDR36C1
Type:
Enzyme
Mol. Mass.:
28974.46
Organism:
Homo sapiens (Human)
Description:
P15428
Residue:
266
Sequence:
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNGAIMKITTSKGIHFQDYDTTPFQAKTQ
  
Inhibitor
Name:
BDBM347370
Synonyms:
US10301320, ID SW208068 | US10869871, ID # SW208068 | US20230285402, ID # SW208068 | US9789116, SW208068
Type:
Small organic molecule
Emp. Form.:
C9H14N2S
Mol. Mass.:
182.286
SMILES:
CCCCSc1ncccc1N
Structure:
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