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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50071880
Substrate
n/a
Meas. Tech.
ChEBML_148191
IC50
500±n/a nM
Citation
 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Pyrroles and other heterocycles as inhibitors of p38 kinase. Bioorg Med Chem Lett 8:2689-94 (1999) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
Csbp1 | Csbp2 | MAP kinase p38 alpha | MK14_RAT | Mapk14
Type:
PROTEIN
Mol. Mass.:
41315.23
Organism:
Rattus norvegicus
Description:
ChEMBL_148191
Residue:
360
Sequence:
MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50071880
Synonyms:
2-(4-Chloro-phenyl)-5-(4-fluoro-phenyl)-4-pyridin-4-yl-1,2-dihydro-pyrazol-3-one | CHEMBL330010
Type:
Small organic molecule
Emp. Form.:
C20H13ClFN3O
Mol. Mass.:
365.788
SMILES:
Fc1ccc(cc1)-c1[nH]n(-c2ccc(Cl)cc2)c(=O)c1-c1ccncc1
Structure:
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