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Target
Motilin receptor
Ligand
BDBM50254970
Substrate
n/a
Meas. Tech.
ChEMBL_559937 (CHEMBL1013731)
EC50
5.01±n/a nM
Citation
 Westaway, SM; Brown, SL; Conway, E; Heightman, TD; Johnson, CN; Lapsley, K; Macdonald, GJ; MacPherson, DT; Mitchell, DJ; Myatt, JW; Seal, JT; Stanway, SJ; Stemp, G; Thompson, M; Celestini, P; Colombo, A; Consonni, A; Gagliardi, S; Riccaboni, M; Ronzoni, S; Briggs, MA; Matthews, KL; Stevens, AJ; Bolton, VJ; Boyfield, I; Jarvie, EM; Stratton, SC; Sanger, GJ The discovery of biaryl carboxamides as novel small molecule agonists of the motilin receptor. Bioorg Med Chem Lett 18:6429-36 (2008) [PubMed]  Article 
Target
Name:
Motilin receptor
Synonyms:
G-protein coupled receptor 38 | GPR38 | MLNR | MTLR | MTLR1 | MTLR_HUMAN
Type:
PROTEIN
Mol. Mass.:
45365.95
Organism:
Homo sapiens (Human)
Description:
ChEMBL_122664
Residue:
412
Sequence:
MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG
  
Inhibitor
Name:
BDBM50254970
Synonyms:
CHEMBL479419 | [4'-((3R,5S)-3,5-Dimethyl-piperazin-1-ylmethyl)-biphenyl-2-yl]-(4-phenylamino-piperidin-1-yl)-methanone
Type:
Small organic molecule
Emp. Form.:
C31H38N4O
Mol. Mass.:
482.6596
SMILES:
C[C@H]1CN(Cc2ccc(cc2)-c2ccccc2C(=O)N2CCC(CC2)Nc2ccccc2)C[C@@H](C)N1 |r|
Structure:
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