Reaction Details Report a problem with these data
Target
Glutamate racemase
Ligand
BDBM50256537
Substrate
n/a
Meas. Tech.
ChEMBL_519359 (CHEMBL948780)
IC50
500±n/a nM
Citation
 Geng, B; Basarab, G; Comita-Prevoir, J; Gowravaram, M; Hill, P; Kiely, A; Loch, J; MacPherson, L; Morningstar, M; Mullen, G; Osimboni, E; Satz, A; Eyermann, C; Lundqvist, T Potent and selective inhibitors of Helicobacter pylori glutamate racemase (MurI): pyridodiazepine amines. Bioorg Med Chem Lett 19:930-6 (2009) [PubMed]  Article 
Target
Name:
Glutamate racemase
Synonyms:
MURI_HELPJ | glr | murI
Type:
PROTEIN
Mol. Mass.:
28499.39
Organism:
Helicobacter pylori J99
Description:
ChEMBL_842443
Residue:
255
Sequence:
MKIGVFDSGVGGFSVLKSLLKARLFDEIIYYGDSARVPYGTKDPTTIKQFGLEALDFFKPHEIELLIVACNTASALALEEMQKYSKIPIVGVIEPSILAIKRQVEDKNAPILVLGTKATIQSNAYDNALKQQGYLNISHLATSLFVPLIEESILEGELLETCMHYYFTPLEILPEVIILGCTHFPLIAQKIEGYFMGHFALPTPPLLIHSGDAIVEYLQQKYALKNNACTFPKVEFHASGDVIWLERQAKEWLKL
  
Inhibitor
Name:
BDBM50256537
Synonyms:
1-(5-phenyl-3-(thiophen-2-yl)-3H-benzo[e][1,4]diazepin-2-yl)azetidin-3-ol | CHEMBL519285
Type:
Small organic molecule
Emp. Form.:
C22H19N3OS
Mol. Mass.:
373.471
SMILES:
OC1CN(C1)C1=Nc2ccccc2C(=NC1c1cccs1)c1ccccc1 |c:15,t:6|
Structure:
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