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Target
Proteasome subunit beta type-5
Ligand
BDBM50307480
Substrate
n/a
Meas. Tech.
ChEMBL_611028 (CHEMBL1073017)
IC50
3±n/a nM
Citation
 Geurink, PP; Liu, N; Spaans, MP; Downey, SL; van den Nieuwendijk, AM; van der Marel, GA; Kisselev, AF; Florea, BI; Overkleeft, HS Incorporation of fluorinated phenylalanine generates highly specific inhibitor of proteasome's chymotrypsin-like sites. J Med Chem 53:2319-23 (2010) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-5
Synonyms:
20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X
Type:
Protein
Mol. Mass.:
28480.96
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
  
Inhibitor
Name:
BDBM50307480
Synonyms:
CHEMBL579296 | Pyrazine-2-carboxylic acid(1-[3-methyl-1-(2,9,9-trimethyl-3,5-dioxa-4-boratri-cyclo[6.1.1.02,6]dec-4-yl)-butylcarbamoyl]-2-(3,5-bis(trifluoromethyl)phenyl)ethyl)-amide
Type:
Small organic molecule
Emp. Form.:
C31H37BF6N4O4
Mol. Mass.:
654.451
SMILES:
CC(C)C[C@H](NC(=O)[C@H](Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)NC(=O)c1cnccn1)B1OC2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1 |r|
Structure:
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