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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Ligand
BDBM50101145
Substrate
n/a
Meas. Tech.
ChEMBL_749 (CHEMBL884527)
IC50
41±n/a nM
Citation
 Lesuisse, D; Gourvest, JF; Albert, E; Doucet, B; Hartmann, C; Lefrançois, JM; Tessier, S; Tric, B; Teutsch, G Biphenyls as surrogates of the steroidal backbone. Part 2: discovery of a novel family of non-steroidal 5-alpha-reductase inhibitors. Bioorg Med Chem Lett 11:1713-6 (2001) [PubMed]  Article 
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 2 | 5 alpha-SR2 | 5α-Reductase 2 (5α-R2) | S5A2_HUMAN | SR type 2 | SRD5A2 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 2 | Type II 5-alpha reductase
Type:
Enzyme
Mol. Mass.:
28406.59
Organism:
Homo sapiens (Human)
Description:
P31213
Residue:
254
Sequence:
MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPAGILARQPLSLFGPPGTVLLGLFCLHYFHRTFVYSLLNRGRPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF
  
Inhibitor
Name:
BDBM50101145
Synonyms:
(4aR,6aS,7S,11aR)-4a,6a-Dimethyl-2-oxo-hexadecahydro-indeno[5,4-f]quinoline-7-carboxylic acid diisopropylamide | CHEMBL297697
Type:
Small organic molecule
Emp. Form.:
C25H42N2O2
Mol. Mass.:
402.6132
SMILES:
CC(C)N(C(C)C)C(=O)[C@H]1CCC2C3CC[C@H]4NC(=O)CC[C@]4(C)C3CC[C@]12C
Structure:
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