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Target
Thymidine kinase, cytosolic
Ligand
BDBM50118488
Substrate
n/a
Meas. Tech.
ChEMBL_210617 (CHEMBL811734)
IC50
17000±n/a nM
Citation
 Hernández, AI; Balzarini, J; Karlsson, A; Camarasa, MJ; Pérez-Pérez, MJ Acyclic nucleoside analogues as novel inhibitors of human mitochondrial thymidine kinase. J Med Chem 45:4254-63 (2002) [PubMed]  Article 
Target
Name:
Thymidine kinase, cytosolic
Synonyms:
KITH_HUMAN | TK1
Type:
PROTEIN
Mol. Mass.:
25476.50
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1333884
Residue:
234
Sequence:
MSCINLPTVLPGSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRYSSSFCTHDRNTMEALPACLLRDVAQEALGVAVIGIDEGQFFPDIVEFCEAMANAGKTVIVAALDGTFQRKPFGAILNLVPLAESVVKLTAVCMECFREAAYTKRLGTEKEVEVIGGADKYHSVCRLCYFKKASGQPAGPDNKENCPVPGKPGEAVAARKLFAPQQILQCSPAN
  
Inhibitor
Name:
BDBM50118488
Synonyms:
1-(2,3-Dihydroxy-4-trityloxy-butyl)-5-methyl-1H-pyrimidine-2,4-dione | CHEMBL135863
Type:
Small organic molecule
Emp. Form.:
C28H28N2O5
Mol. Mass.:
472.5323
SMILES:
Cc1cn(CC(O)C(O)COC(c2ccccc2)(c2ccccc2)c2ccccc2)c(=O)[nH]c1=O
Structure:
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