Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 3
Ligand
BDBM50264142
Substrate
n/a
Meas. Tech.
ChEMBL_535295 (CHEMBL982620)
IC50
20.0±n/a nM
Citation
 Sato, I; Morihira, K; Inami, H; Kubota, H; Morokata, T; Suzuki, K; Iura, Y; Nitta, A; Imaoka, T; Takahashi, T; Takeuchi, M; Ohta, M; Tsukamoto, S Design and synthesis of 6-fluoro-2-naphthyl derivatives as novel CCR3 antagonists with reduced CYP2D6 inhibition. Bioorg Med Chem 16:8607-18 (2008) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 3
Synonyms:
C-C CKR-3 | C-C chemokine receptor type 3 (CCR3) | CC-CKR-3 | CCR-3 | CCR3 | CCR3_HUMAN | CD_antigen=CD193 | CKR3 | CMKBR3 | Eosinophil eotaxin receptor
Type:
Enzyme
Mol. Mass.:
41053.88
Organism:
Homo sapiens (Human)
Description:
P51677
Residue:
355
Sequence:
MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
  
Inhibitor
Name:
BDBM50264142
Synonyms:
Biphenyl-2-carboxylic acid [(1R,5R)-8-(6-fluoro-naphthalen-2-ylmethyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-amide | Biphenyl-2-carboxylic acid [8-(6-fluoro-naphthalen-2-ylmethyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-amide | CHEMBL522295 | N-(8-((6-fluoronaphthalen-2-yl)methyl)-8-azabicyclo[3.2.1]octan-3-yl)biphenyl-2-carboxamide
Type:
Small organic molecule
Emp. Form.:
C31H29FN2O
Mol. Mass.:
464.5732
SMILES:
Fc1ccc2cc(CN3C4CCC3CC(C4)NC(=O)c3ccccc3-c3ccccc3)ccc2c1 |TLB:7:8:14.15.13:10.11,16:14:8:10.11|
Structure:
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