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Target
Histone acetyltransferase KAT2B
Ligand
BDBM50247589
Substrate
n/a
Meas. Tech.
ChEMBL_495684 (CHEMBL1006963)
IC50
102000±n/a nM
Citation
 Gorsuch, S; Bavetsias, V; Rowlands, MG; Aherne, GW; Workman, P; Jarman, M; McDonald, E Synthesis of isothiazol-3-one derivatives as inhibitors of histone acetyltransferases (HATs). Bioorg Med Chem 17:467-74 (2009) [PubMed]  Article 
Target
Name:
Histone acetyltransferase KAT2B
Synonyms:
Histone acetyltransferase KAT2A/KAT2B | Histone acetyltransferase PCAF | KAT2B | KAT2B_HUMAN | PCAF
Type:
PROTEIN
Mol. Mass.:
93045.76
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1502838
Residue:
832
Sequence:
MSEAGGAGPGGCGAGAGAGAGPGALPPQPAALPPAPPQGSPCAAAAGGSGACGPATAVAAAGTAEGPGGGGSARIAVKKAQLRSAPRAKKLEKLGVYSACKAEESCKCNGWKNPNPSPTPPRADLQQIIVSLTESCRSCSHALAAHVSHLENVSEEEMNRLLGIVLDVEYLFTCVHKEEDADTKQVYFYLFKLLRKSILQRGKPVVEGSLEKKPPFEKPSIEQGVNNFVQYKFSHLPAKERQTIVELAKMFLNRINYWHLEAPSQRRLRSPNDDISGYKENYTRWLCYCNVPQFCDSLPRYETTQVFGRTLLRSVFTVMRRQLLEQARQEKDKLPLEKRTLILTHFPKFLSMLEEEVYSQNSPIWDQDFLSASSRTSQLGIQTVINPPPVAGTISYNSTSSSLEQPNAGSSSPACKASSGLEANPGEKRKMTDSHVLEEAKKPRVMGDIPMELINEVMSTITDPAAMLGPETNFLSAHSARDEAARLEERRGVIEFHVVGNSLNQKPNKKILMWLVGLQNVFSHQLPRMPKEYITRLVFDPKHKTLALIKDGRVIGGICFRMFPSQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHDILNFLTYADEYAIGYFKKQGFSKEIKIPKTKYVGYIKDYEGATLMGCELNPRIPYTEFSVIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKDGVRQIPIESIPGIRETGWKPSGKEKSKEPRDPDQLYSTLKSILQQVKSHQSAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLKNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYKCANILEKFFFSKIKEAGLIDK
  
Inhibitor
Name:
BDBM50247589
Synonyms:
4-Methoxymethyl-2-phenyl-isothiazol-3(2H)-one | CHEMBL489896
Type:
Small organic molecule
Emp. Form.:
C11H11NO2S
Mol. Mass.:
221.276
SMILES:
COCc1csn(-c2ccccc2)c1=O
Structure:
Search PDB for entries with ligand similarity: