Reaction Details Report a problem with these data
Target
Ceramide glucosyltransferase
Ligand
BDBM50379051
Substrate
n/a
Meas. Tech.
ChEMBL_809643 (CHEMBL2015862)
IC50
>10000±n/a nM
Citation
 van den Berg, RJ; Wennekes, T; Ghisaidoobe, A; Donker-Koopman, WE; Strijland, A; Boot, RG; van der Marel, GA; Aerts, JM; Overkleeft, HS Assessment of partially deoxygenated deoxynojirimycin derivatives as glucosylceramide synthase inhibitors. ACS Med Chem Lett 2:519-522 (2011) [PubMed]  Article 
Target
Name:
Ceramide glucosyltransferase
Synonyms:
CEGT_MOUSE | Ugcg
Type:
PROTEIN
Mol. Mass.:
44844.15
Organism:
Mus musculus
Description:
ChEMBL_809643
Residue:
394
Sequence:
MALLDLAQEGMALFGFVLFVVLWLMHFMSIIYTRLHLNKKATDKQPYSKLPGVSLLKPLKGVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVGINPKINNLMPAYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGFAATLEQVYFGTSHPRSYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMAKAIADRGWRFSMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVASLIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMTIYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
  
Inhibitor
Name:
BDBM50379051
Synonyms:
CHEMBL2011624
Type:
Small organic molecule
Emp. Form.:
C22H39NO3
Mol. Mass.:
365.55
SMILES:
OC[C@H]1[C@@H](O)CCCN1CCCCCOCC12CC3CC(CC(C3)C1)C2 |r,THB:15:16:19:23.21.22,21:20:17:23.22.24,21:22:19.20.25:17,24:22:19:25.16.17,24:16:19:23.21.22|
Structure:
Search PDB for entries with ligand similarity: