Reaction Details Report a problem with these data
Target
Beta-lactamase SHV-1
Ligand
BDBM152696
Substrate
n/a
Meas. Tech.
Steady-State Kinetics Assay
pH
7.4±n/a
Ki
5.6e+2± 5e+1 nM
IC50
3.2e+2± 3e+1 nM
Comments
extracted
Citation
 Che, T; Rodkey, EA; Bethel, CR; Shanmugam, S; Ding, Z; Pusztai-Carey, M; Nottingham, M; Chai, W; Buynak, JD; Bonomo, RA; van den Akker, F; Carey, PR Detecting a quasi-stable imine species on the reaction pathway of SHV-1 ß-lactamase and 6ß-(hydroxymethyl)penicillanic acid sulfone. Biochemistry 54:734-43 (2015) [PubMed]  Article 
Target
Name:
Beta-lactamase SHV-1
Synonyms:
BLA1_KLEPN | Beta-lactamase SHV-1 | SHV-1 beta-lactamase | bla | shv1
Type:
Protein
Mol. Mass.:
31226.68
Organism:
Klebsiella pneumoniae (Enterobacteria)
Description:
4R3B
Residue:
286
Sequence:
MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR
  
Inhibitor
Name:
BDBM152696
Synonyms:
PSR-3-283A
Type:
Small organic molecule
Emp. Form.:
C9H12NO6S
Mol. Mass.:
262.26
SMILES:
[H][C@@]12[C@H](CO)C(=O)N1[C@@H](C([O-])=O)C(C)(C)S2(=O)=O |r,@@:12|
Structure:
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