Reaction Details Report a problem with these data
Target
11-beta-hydroxysteroid dehydrogenase type 2
Ligand
BDBM167434
Substrate
n/a
Meas. Tech.
Homogenous Time-Resolved Fluorescence (HTRF) Assay
IC50
>10000±n/a nM
Citation
 Kim, KY; Ahn, JH; Kang, SK; Rhee, SD; Bae, MA; Ahn, SH; Kim, HY; Jung, WH; Kang, NS Sulfamide derivative having an adamantyl group and its pharmaceutically acceptable salt US Patent  US9073906 Publication Date 7/7/2015 
Target
Name:
11-beta-hydroxysteroid dehydrogenase type 2
Synonyms:
11-DH2 | 11-beta-HSD2 | 11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 2 | 11-beta-hydroxysteroid dehydrogenase type 2 | 11-beta-hydroxysteroid dehydrogenase type 2 (11-beta-HSD2) | Corticosteroid 11-beta-dehydrogenase isozyme 2 | DHI2_HUMAN | HSD11B2 | HSD11K | NAD-dependent 11-beta-hydroxysteroid dehydrogenase | SDR9C3
Type:
Enzyme
Mol. Mass.:
44141.72
Organism:
Homo sapiens (Human)
Description:
Purified recombinant human 11beta-HSD2.
Residue:
405
Sequence:
MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR
  
Inhibitor
Name:
BDBM167434
Synonyms:
US9073906, 44
Type:
Small organic molecule
Emp. Form.:
C22H29FN4O4S
Mol. Mass.:
464.553
SMILES:
NC(=O)C12CC3CC(C1)C(NC(=O)CN1CCCN(c4ccc(F)cc4)S1(=O)=O)C(C3)C2 |TLB:6:5:31:9.7.8,6:7:31:5.4.30,THB:10:9:31:5.4.30,10:9:5.6.30:31.3.8,4:5:9:31.3.8,4:3:9:5.6.30,(6.04,5.23,;5.13,3.99,;3.6,4.16,;5.74,2.58,;7.27,2.41,;7.89,1,;7.84,-1.13,;6.47,-1,;5.52,1.21,;5.45,-2.15,;4.12,-2.92,;2.78,-2.15,;2.78,-.61,;1.45,-2.92,;.11,-2.15,;.11,-.61,;-1.22,.16,;-2.55,-.61,;-2.55,-2.15,;-3.89,-2.92,;-5.22,-2.15,;-6.55,-2.92,;-6.55,-4.46,;-7.89,-5.23,;-5.22,-5.23,;-3.89,-4.46,;-1.22,-2.92,;-.45,-4.25,;-1.99,-4.25,;5.45,-.07,;6.98,-.24,;4.83,1.34,)|
Structure:
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