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Target
Macrophage colony-stimulating factor 1 receptor [538-972]
Ligand
BDBM181019
Substrate
n/a
Meas. Tech.
Enzymatic Assay
pH
7.5±n/a
Temperature
303.15±n/a K
IC50
3±n/a nM
Comments
extracted
Citation
 Flynn, DL; Kaufman, MD; Samarakoon, T; Caldwell, TM; Vogeti, L; Ahn, Y; Patt, WC; Yates, KM Imidazolidinones and analogs exhibiting anti-cancer and anti-proliferative activities US Patent  US9133183 Publication Date 9/15/2015 
Target
Name:
Macrophage colony-stimulating factor 1 receptor [538-972]
Synonyms:
CSF1R | CSF1R_HUMAN | FMS | Proto-oncogene c-Fms | cFMS
Type:
Other Protein Type
Mol. Mass.:
48843.65
Organism:
Homo sapiens (Human)
Description:
Recombinant protein contains the full-length FMS cytoplasmic domain (FMS538-972.6His).
Residue:
435
Sequence:
YKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC
  
Inhibitor
Name:
BDBM181019
Synonyms:
US9133183, Example 15
Type:
Small organic molecule
Emp. Form.:
C24H27N7O3
Mol. Mass.:
461.5163
SMILES:
Cn1cc(cn1)-c1cc(Oc2ccc(NC(=O)N3CCN(C4CCCCC4)C3=O)nc2)ccn1
Structure:
Search PDB for entries with ligand similarity: