BDBM50416875 AMG-073::AMG073 HCL::CINACALCET::CINACALCET HYDROCHLORIDE::US9487494, Cinacalcet
SMILES C[C@@H](NCCCc1cccc(c1)C(F)(F)F)c1cccc2ccccc12
InChI Key InChIKey=VDHAWDNDOKGFTD-MRXNPFEDSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50416875
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
University Of Pittsburgh
Curated by ChEMBL
University Of Pittsburgh
Curated by ChEMBL
Affinity DataEC50: 320nMAssay Description:Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-el...More data for this Ligand-Target Pair
Affinity DataEC50: 80nMAssay Description:Positive allosteric modulation of human CaSR transfected in CHO cells after 5 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 180nMAssay Description:Agonist activity at human CaSR expressed in CHO cells assessed as increase in intracellular calcium mobilization after 1 hr by Fura-2 dye-based fluor...More data for this Ligand-Target Pair
Affinity DataEC50: 19.9nMAssay Description:Positive allosteric modulation of calcium sensing receptor by cell based assayMore data for this Ligand-Target Pair