BDBM120095 US10525036, Example GDC-0994::US10934304, Example GDC-0994::US8697715, 39::US9259470, 39

SMILES Cn1nccc1Nc1nccc(n1)-c1ccn([C@H](CO)c2ccc(Cl)c(F)c2)c(=O)c1

InChI Key InChIKey=RZUOCXOYPYGSKL-GOSISDBHSA-N

Data  17 IC50  5 Kd

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 120095   

TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM120095(US10525036, Example GDC-0994 | US10934304, Example...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM120095(US10525036, Example GDC-0994 | US10934304, Example...)
Affinity DataIC50:  86nMAssay Description:Inhibition of ERK2 in human A375 cells harboring BRAF V600E mutant assessed as decrease in phosphorylated ERK2 levelsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM120095(US10525036, Example GDC-0994 | US10934304, Example...)
Affinity DataIC50:  140nMAssay Description:Inhibition of ERK2 in human A375 cells harboring BRAF V600E mutant assessed as decrease in phosphorylated RSK levelsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1/3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM120095(US10525036, Example GDC-0994 | US10934304, Example...)
Affinity DataIC50:  86nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of RSK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1/3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM120095(US10525036, Example GDC-0994 | US10934304, Example...)
Affinity DataIC50:  31nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of ERK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM120095(US10525036, Example GDC-0994 | US10934304, Example...)
Affinity DataKd:  1.60nMAssay Description:Binding affinity to non-phosphorylated biotinylated ERK2 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM120095(US10525036, Example GDC-0994 | US10934304, Example...)
Affinity DataKd:  1.60nMAssay Description:Binding affinity to MEK-activated phosphorylated biotinylated ERK2 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair