BDBM195086 US10336717, Compound 135::US9212153, 135,Ex. 100

SMILES CCN1C(N)=NC2(C1=O)c1cc(ccc1CC21CCC(CC1)OC)-c1cccc(c1)C#N

InChI Key InChIKey=GGFKADSGLCZWRD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 195086   

TargetBeta-secretase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM195086(US10336717, Compound 135 | US9212153, 135,Ex. 100)
Affinity DataIC50:  7.30nMAssay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1 [1-458](Homo sapiens (Human))
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM195086(US10336717, Compound 135 | US9212153, 135,Ex. 100)
Affinity DataIC50:  7.30nMpH: 4.5 T: 2°CAssay Description:Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity using commercially available substrate HiLyte Fluor 488...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent