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Found
1
Enz. Inhib. hit(s) with Target = 'Beta-secretase 1 [1-458]' and Ligand = 'BDBM195086'
Target
Beta-secretase 1 [1-458]
(Homo sapiens (Human))
Vitae Pharmaceuticals
US Patent
Ligand
BDBM195086
(US10336717, Compound 135 | US9212153, 135,Ex. 100)
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Affinity Data
IC50: 7.30nM
pH: 4.5 T: 2°C
Assay Description:
Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity using commercially available substrate HiLyte Fluor 488...
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Ligand Info
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