BDBM202141 US9233983, I-12
SMILES CCN1CCN(Cc2ccc(nc2)-c2cc3c(ccnc3[nH]2)-c2cccc(N3CCOc4cc(cc(F)c4C3=O)C3CC3)c2CO)CC1
InChI Key InChIKey=HCGIQPXUFZJBIW-UHFFFAOYSA-N
Data 12 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 202141
Affinity DataIC50: 2nMAssay Description:The inhibition assays were performed using the generic tyrosine kinase
assay kit from C is Bio (HTRF KinEASE-TK #62TK0PEB). The assay is based
on t...More data for this Ligand-Target Pair
Affinity DataIC50: 2.60nMAssay Description:Inhibition of recombinant human full length BTK preincubated for 10 mins followed by Tk-biotin peptide substrate addition after 90 mins by TR-FRET as...More data for this Ligand-Target Pair
Affinity DataIC50: 8.40nMAssay Description:Inhibition of C57BL/6J mouse BTK assessed as decrease in anti-mouse IgM antibody stimulated BCR mediated CD69 upregulation preincubated for 30 mins f...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human full length ITK preincubated for 10 mins followed by Tk-biotin peptide substrate addition after 60 mins by TR-FRET as...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of TXK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5.06E+3nMAssay Description:Inhibition of mouse BTK assessed as decrease in anti-CD3epsilon antibody stimulated TCR mediated CD69 upregulation in whole blood preincubated for 1 ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human JAK3 (781 to 1124 residues) preincubated for 10 mins followed by poly-[Glu-Tyr(4:1) substrate addition after 60 mins ...More data for this Ligand-Target Pair
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Advinus Therapeutics
Curated by ChEMBL
Advinus Therapeutics
Curated by ChEMBL
Affinity DataIC50: 1.55E+3nMAssay Description:Inhibition of human BMXMore data for this Ligand-Target Pair
Affinity DataIC50: 84nMAssay Description:Inhibition of human BTK assessed as decrease in anti-mouse IgD antibody stimulated BCR mediated CD69 upregulation in whole blood preincubated for 1 h...More data for this Ligand-Target Pair
Affinity DataIC50: 159nMAssay Description:Inhibition of mouse BTK assessed as decrease in anti-mouse IgD antibody stimulated BCR mediated CD69 upregulation in whole blood preincubated for 1 h...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair