BDBM24709 6,9-Diamino-2-Ethoxyacridine::7-ethoxyacridine-3,9-diamine::CHEMBL94007

SMILES CCOc1ccc2nc3cc(N)ccc3c(N)c2c1

InChI Key InChIKey=CIKWKGFPFXJVGW-UHFFFAOYSA-N

Data  3 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 24709   

TargetAcetylcholinesterase(Homo sapiens (Human))
University of North Carolina At Chapel Hill

LigandPNGBDBM24709(6,9-Diamino-2-Ethoxyacridine | 7-ethoxyacridine-3,...)
Affinity DataKi:  490nM ΔG°:  -8.52kcal/molepH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
University of North Carolina At Chapel Hill

LigandPNGBDBM24709(6,9-Diamino-2-Ethoxyacridine | 7-ethoxyacridine-3,...)
Affinity DataKi:  1.71E+4nM ΔG°:  -6.43kcal/molepH: 7.4 T: 2°CAssay Description:Inhibition constants were calculated by assessment of the reduction in the formation of o-nitrophenol, as monitored by a spectrophotometric assay at ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
University of North Carolina At Chapel Hill

LigandPNGBDBM24709(6,9-Diamino-2-Ethoxyacridine | 7-ethoxyacridine-3,...)
Affinity DataKi: >1.00E+5nM ΔG°: >-5.40kcal/molepH: 7.4 T: 2°CAssay Description:Inhibition constants were calculated by assessment of the reduction in the formation of o-nitrophenol, as monitored by a spectrophotometric assay at ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM24709(6,9-Diamino-2-Ethoxyacridine | 7-ethoxyacridine-3,...)
Affinity DataIC50:  4.35E+4nMAssay Description:Inhibition of [3H]N-propylnorapomorphine binding to Dopamine receptor D2 of rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of Missouri

Curated by ChEMBL
LigandPNGBDBM24709(6,9-Diamino-2-Ethoxyacridine | 7-ethoxyacridine-3,...)
Affinity DataIC50:  8.20E+3nMAssay Description:Inhibitory activity of the compound against telomerase (Compound released from DNA/DNA heteroduplex derivatized resin [sequence (TTAGGG)3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of Missouri

Curated by ChEMBL
LigandPNGBDBM24709(6,9-Diamino-2-Ethoxyacridine | 7-ethoxyacridine-3,...)
Affinity DataIC50:  8.20E+3nMAssay Description:Inhibitory activity of the compound against telomerase (Compound released from underivatized resinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
University Of Missouri

Curated by ChEMBL
LigandPNGBDBM24709(6,9-Diamino-2-Ethoxyacridine | 7-ethoxyacridine-3,...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of HIV-1 reverse transcriptase using Poly(rA).p(dT) (12 to 18) as substrate after 30 mins by single point PCR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of Missouri

Curated by ChEMBL
LigandPNGBDBM24709(6,9-Diamino-2-Ethoxyacridine | 7-ethoxyacridine-3,...)
Affinity DataIC50:  8.20E+3nMAssay Description:Inhibitory activity of the compound against telomerase (Compound released from underivatized resinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed