BDBM24710 6-chloro-2-methoxyacridin-9-amine::9-Amino-6-Chloro-2-Methoxyacridine

SMILES COc1ccc2nc3cc(Cl)ccc3c(N)c2c1

InChI Key InChIKey=IHHSSHCBRVYGJX-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 24710   

TargetAcetylcholinesterase(Homo sapiens (Human))
University of North Carolina At Chapel Hill

LigandPNGBDBM24710(6-chloro-2-methoxyacridin-9-amine | 9-Amino-6-Chlo...)
Affinity DataKi:  49nM ΔG°:  -9.86kcal/molepH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
University of North Carolina At Chapel Hill

LigandPNGBDBM24710(6-chloro-2-methoxyacridin-9-amine | 9-Amino-6-Chlo...)
Affinity DataKi:  5.80E+3nM ΔG°:  -7.07kcal/molepH: 7.4 T: 2°CAssay Description:Inhibition constants were calculated by assessment of the reduction in the formation of o-nitrophenol, as monitored by a spectrophotometric assay at ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Heidelberg University

Curated by ChEMBL
LigandPNGBDBM24710(6-chloro-2-methoxyacridin-9-amine | 9-Amino-6-Chlo...)
Affinity DataKi:  7.00E+3nMAssay Description:The competitive inhibitory activity against trypanothione reductase was evaluated from Lineweaver Burk plotsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
University of North Carolina At Chapel Hill

LigandPNGBDBM24710(6-chloro-2-methoxyacridin-9-amine | 9-Amino-6-Chlo...)
Affinity DataKi: >1.00E+5nM ΔG°: >-5.40kcal/molepH: 7.4 T: 2°CAssay Description:Inhibition constants were calculated by assessment of the reduction in the formation of o-nitrophenol, as monitored by a spectrophotometric assay at ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed