BDBM28494 (3R,5S)-5-[2-(4-{[3-chloro-4-(pyridin-2-yloxy)phenyl]amino}thieno[3,2-d]pyrimidin-6-yl)ethynyl]pyrrolidin-3-yl morpholine-4-carboxylate::alkynyl thienopyrimidine, 15f

SMILES Clc1cc(Nc2ncnc3cc(sc23)C#C[C@@H]2C[C@H](CN2)OC(=O)N2CCOCC2)ccc1Oc1ccccn1

InChI Key InChIKey=LJKWMYHCZOUEOQ-UYAOXDASSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 28494   

TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Gsk

LigandPNGBDBM28494((3R,5S)-5-[2-(4-{[3-chloro-4-(pyridin-2-yloxy)phen...)
Affinity DataIC50:  60nMAssay Description:Assays were performed in 96-well polystyrene round-bottomed plates in reaction buffer containing biotinylated substrate and purified kinase in the pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM28494((3R,5S)-5-[2-(4-{[3-chloro-4-(pyridin-2-yloxy)phen...)
Affinity DataIC50:  190nMpH: 7.5 T: 2°CAssay Description:Assays were performed in 96-well polystyrene round-bottomed plates in reaction buffer containing biotinylated substrate and purified kinase in the pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed