BDBM312616 US9604998, Example 22::US9604998, Example 23

SMILES Cc1c(ccc(F)c1[N+]#[C-])[C@@H]1CN2CCN(CC(O)c3cccc(c3)-n3cnnn3)C[C@@H]2CO1

InChI Key InChIKey=DTGYAMGHQPSIOC-QREQTRJTSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 312616   

TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM312616(US9604998, Example 22 | US9604998, Example 23)
Affinity DataIC50:  120nMAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM312616(US9604998, Example 22 | US9604998, Example 23)
Affinity DataIC50:  440nMAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent